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Vikas Goel Email & Phone Number

Executive Director of Cancer Biology and Translational Research at Zafrens at Zafrens
Location: San Diego, California, United States 14 work roles 3 schools
2 work emails found @aexp.com 1 phone found area 617 LinkedIn matched
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Direct phone (617) ***-****
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Current company
Role
Executive Director of Cancer Biology and Translational Research at Zafrens
Location
San Diego, California, United States

Who is Vikas Goel? Overview

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Vikas Goel is listed as Executive Director of Cancer Biology and Translational Research at Zafrens at Zafrens, based in San Diego, California, United States. AeroLeads shows a work email signal at aexp.com, phone signal with area code 617, and a matched LinkedIn profile for Vikas Goel.

Vikas Goel previously worked as Executive Director (Head of Biology) at Zafrens and Director of Cancer Biology and Translational Research at Turning Point Therapeutics. Vikas Goel holds Doctor Of Philosophy (Ph.D.), Molecular Microbiology from All India Institute Of Medical Sciences.

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Profile bio

About Vikas Goel

An accomplished leader in cancer biology and drug discovery with a proven track record of advancing five development candidates to the clinic, including contributing to the development of one FDA-approved drug. Led teams in delivering drug candidates and preclinical data for biomarker-driven combination trials. Author of 38 publications and inventor on two patents. Known for strong verbal and written communication skills, team-building, and problem-solving abilities, with extensive experience collaborating with cross-functional teams to successfully lead projects from discovery through to the clinic.Led multi-disciplinary team to develop complex multi-phenotypic ultra-high throughput screening assays (DNA Encoded Library of small molecule screen for multiple classes of targets, kinases, PPI, GTPases, RNABPs, RTKs, methyltransferase, and Transcription factors), IF, cell painting, co-culture antibody functional screen and biologicsTeam leader in the discovery of the innovative MNK1/2 inhibitor (eFT508) concept in immuno-oncology and CAR T cell program, which set a new milestone at eFFECTOR Therapeutics for developing the combination trials of eFT508 with ICI with partnersAs a group leader, fostering a collaborative and productive matrix work environment Managing multiple CROs for the in-vivo pharmacology, murine TGI in CDX, PDX, syngeneic, and GEMM models, PK/PD, MTD and DRF studiesLed the discovery and development of novel translational PD biomarkers assay for Phase I/II clinical trials. Design and execute the PK/PD analysis and in vivo response evaluation of drug candidates for targeted single-agent or combination therapiesDevelop the preclinical translational data to differentiate PHASE I/II assets from competitors, extend the life cycle of clinical assets for bucket clinical trialsWrote major sections (non-clinical pharmacology) of IND (tomivosertib), IB, DSUR, IND (elzoventinib, TPX-0131), ODD (elzoventinib and TPX-0131), IMPD (elzoventinib), and NDA(repotrectinib)Active partner with the Business Development team for SWOT analysis, competitive intelligence, and due diligence of a wide range (small molecules, degraders, and biotherapeutics) of early to late targets for licensing Inviting KOLs and working with SAB team members, key stakeholders, and academic experts to initiate and oversee investigator-sponsored studies to advance the pipeline and translational projectsCore team member responsible for managing the portfolio strategies, preparing the data package, and presenting to the Executive Leadership Team and external partners

Listed skills include Cell Culture, Cell Biology, Cell, Molecular Biology, and 59 others.

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Zafrens
Zafrens
Executive Director of Cancer Biology and Translational Research at Zafrens
AeroLeads page
14 roles

Vikas Goel work experience

A career timeline built from the work history available for this profile.

Executive Director (Head Of Biology)

Current

San Diego, California, US

In my role as the Executive Director at Zafrens, I led the multidisciplinary team in setting up ultra-high throughput phenotypic screens(reporter, target-based biomarkers, and cell painting) for drug discovery (small molecules and biologics), successfully validating top targets for internal programs.Managed the discovery of novel chemical entities (NCEs).

Mar 2023 - Present

Director Of Cancer Biology And Translational Research

San Diego, CA, US

Led a multidisciplinary team of 11 scientists, managing biology and biochemistry research to support discovery and translational activitiesOversaw resource allocation, budgeting (capital and operational), and project prioritization for the research teamKey member of the research portfolio team, presenting discovery and translational programs, innovative.

Jun 2020 - Mar 2023

Principal Scientist

Solana Beach, California, US

  • Participate and responsible for data package for portfolio discussion internally and with external collaborators
  • The lead member of the core group of discovery and development of MNK1/2 inhibitor (eFT508), currently evaluated in the Phase II trial
  • Using a large genomic data set (TCGA/CCLE, DEPMAP, RPPA, in-house RNAseq, and Polysome/Ribosome profiling), understand the mechanism(s) of action of STR inhibitors in developing disease hypotheses for rational.
  • Supported combination studies to demonstrate sensitization and the durable response of RTK and KRAS driven tumors models to eIF4E (partnered with Pfizer for the development) and eIF4A (Phase II) inhibitors
  • Successfully designed, and executed the models for Immuno oncology, analyzed PD readouts of tumor-infiltrating lymphocytes (TILs) and cytokine profile using multi-color flow, MSD/ Luminex/ELISA
  • Molecular, cellular, signaling, and functional characterization of immune cells (dendritic cells/APCs, macrophages, and T cell subsets TSCM/TCM/TEM/Treg/Th1/Th2) and cancer cells using small molecule targeted therapies
Jan 2020 - Jun 2020

Senior Scientist

Solana Beach, California, US

Team leader in design, execution, and analysis of CAR T cell and Immuno-oncology program with cross-functional team at eFFECTOR therapeutics.The lead member of project eFT508, an MNK1/2 inhibitor that advanced to Phase II. The lead member of the cross-functional team of eIF4Ei.Using cell surface and internal markers, studying the molecular mechanisms of.

Dec 2015 - Dec 2019

Research Scientist Ii

Solana Beach, California, US

Experience in driving the preclinical drug discovery process from novel target Identification/validation of small molecule inhibitors for selective translation regulators (STRs), a first-in-class dual MNK1/2 kinase inhibitor, eIF4Ei and eIF4Ai from concept, preclinical to Phase I/II trials. Led discovery and development of companion diagnostic novel.

Dec 2013 - Nov 2015

Research Scientist

Seattle, WA, US

In-depth characterization of the immune component of human and murine pancreas cancer using flow cytometry, multicolor IHC, Immunofluorescence (IF), and quantum dot microscopy. Proficient in quantifying/analyzing imaging techniques (bright field and Confocal).Using genomics and primary cells in 3D model system, studied the bidirectional cross-talk within.

May 2013 - Dec 2013

Research Associate Ii

Seattle, WA, US

Utilized advanced cancer genomics and proteomic data for hypothesis-driven molecular mechanisms of metastasis and novel drug targets for pancreas cancer.Developed novel mouse model (GEMMS, KPC, KPDC, and KDC ) to understand the role of sequential mutations of p53 and SMAD4 in metastasis and drug resistance of pancreatic cancer. Enrollment of animals for.

Jan 2009 - Apr 2013

Staff Scientist

Burnham Institute Of Medical Research

We are elucidating the role of ATF2 and hypoxia in the epigenetic regulation of pigmentation and melanoma progression using novel ATF2Flox, INK/ARFFlox, and NRAS TyrCre mouse models. Understand the molecular mechanism of ATF2-dependent genes in melanoma progression using various biochemical assays such as Immunoprecipitation, In-situ hybridization (FISH).

Jan 2008 - Jan 2009

Instructor

Massachusetts General Hospital, Harvard Medical School

Developed novel BRAFV600E, BRAFV600E INK/ARF-/-, and BRAFV600E p53-/- mouse models for deciphering the role of various oncogenes and tumor suppressors in melanoma progression. Using RNA arrays characterized the primary tumors from the BRAFV600E mouse model.Characterized the mutation profile of more than 40 melanoma cell lines and almost 100 melanoma.

Jan 2005 - Dec 2007

Postdoctoral Fellow

Boston, MA, US

  • Study the role of BRAF in melanoma biology, which involves the development and characterization of the BRAFV600E mouse model for melanoma development and progression.
  • Preclinical Trials of BRAFV600E specific inhibitors using BRAFV600E mouse model.
  • Tumor collections from patients for the tumor bank at MGH. Collect and prepare DNA, RNA, and proteins from various sources such as tumors, blood, and other body fluids of preclinical (murine model) and clinical trials.
  • Expert in Immunohistochemistry (IHC) on frozen FFPE tissues and tissue microarrays. Proficient in various imaging techniques (bright field, Confocal, and multiphoton microscopy) and quantification/analysis of IHC/IF.
Jan 2002 - Jan 2005

Senior Research Associate

New Delhi, Delhi, IN

  • Developed in vitro diagnostics PCR assay (IVD) and Indirect Immunofluorescence to detect drug-resistant Plasmodium from blood and diagnostics of Rabies virus from clinical samples.
  • Developed and functionally characterized mouse monoclonal antibodies (hybridoma technology) against Iron Regulated Outer Membrane Proteins of Acinetobacter and their potential use in therapeutics and diagnostics.
Jan 1997 - Jan 2000

Junior Research Associate

New Delhi, Delhi, IN

Identification and Characterization of Iron regulated Outer Membrane Proteins of Acinetobacter baumannii.

Jan 1995 - Jan 1997

All India Institute Of Medical Sciences

Honors And Prizes

Council of Scientific and Industrial Research India, Research Scholarship.

Jan 1995 - Jan 2000

Junior Research Associate

University Of Delhi

Rapid diagnostics of wild type and drug resistance Plasmodium falciparum directly from patients blood using PCR.

Jan 1994 - Jan 1995
3 education records

Vikas Goel education

Doctor Of Philosophy (Ph.D.), Molecular Microbiology

All India Institute Of Medical Sciences

Master Of Philosophy (M.Phil.), Molecular Parasitology

Delhi University

Master'S Degree, Cell And Molecular Biology

Dept. Of Zoology, University Of Delhi
FAQ

Frequently asked questions about Vikas Goel

Quick answers generated from the profile data available on this page.

What company does Vikas Goel work for?

Vikas Goel works for Zafrens.

What is Vikas Goel's role at Zafrens?

Vikas Goel is listed as Executive Director of Cancer Biology and Translational Research at Zafrens at Zafrens.

What is Vikas Goel's email address?

AeroLeads has found 2 work email signals at @aexp.com for Vikas Goel at Zafrens.

What is Vikas Goel's phone number?

AeroLeads has found 1 phone signal(s) with area code 617 for Vikas Goel at Zafrens.

Where is Vikas Goel based?

Vikas Goel is based in San Diego, California, United States while working with Zafrens.

What companies has Vikas Goel worked for?

Vikas Goel has worked for Zafrens, Turning Point Therapeutics, Effector Therapeutics, Inc., University Of Washington, and Fred Hutchinson Cancer Research Center.

How can I contact Vikas Goel?

You can use AeroLeads to view verified contact signals for Vikas Goel at Zafrens, including work email, phone, and LinkedIn data when available.

What schools did Vikas Goel attend?

Vikas Goel holds Doctor Of Philosophy (Ph.D.), Molecular Microbiology from All India Institute Of Medical Sciences.

What skills is Vikas Goel known for?

Vikas Goel is listed with skills including Cell Culture, Cell Biology, Cell, Molecular Biology, Assay Development, In Vitro, Biotechnology, and Protein Chemistry.

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