Vivek Mutalik Email and Phone Number
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I am a Staff scientist and Principal Investigator at the U. S. Dept of Energy’s BRaVE Phage Foundry, Lawrence Berkeley National Laboratory. My group is focused on developing tools and technologies to study/engineer microbes/viruses/bacteriophages and biomolecules for diverse biotechnologies including discovering novel mitigation strategies for eliminating antibiotic resistant infections and designing and building novel bionanomaterials. More details here: https://sites.google.com/lbl.gov/mutaliklabI have more than 40 peer reviewed publications (https://scholar.google.com/citations?user=SD-tU5MAAAAJ&hl=en) both as a first author and senior author contributions. I have more than 10 years of experience in building, leading and managing cross-functional research teams handling synthetic biology, functional genomics and phage engineering projects. I have demonstrated expertise in:• developing high-throughput technologies and next-generation sequencing methods for gene-function discovery • developing genetic tools for engineering of non-model organisms important in diverse synthetic biology applications in biomaterials • studying phage-microbial interaction for applications in phage engineering for microbial manipulation, phage therapy, microbial antibiotic resistance• engineering of viruses/phages, and virus/phage-like particles important in diverse synthetic biology applications • Proven track record in the field of synthetic biology, microbial physiology, phage biology, protein production, metabolic engineering, assay development, statistical multivariate data analysis and design of experiments• I have Industry experience in managing high value 150,000 liter fermentation, bulk drug manufacturing and resource management • I am proficient in rapidly adopt and integrate knowledge from new fields• I am highly productive in collaborative and autonomous environments• I have excellent ability to organize and critically evaluate complex datasets and communicate coherent results.
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Staff ScientistBerkeley Lab May 2021 - PresentBerkeley, Ca, Us
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Research ScientistBerkeley Lab Jun 2012 - May 2021Berkeley, Ca, Us- Established high-throughput genomics platform for functional discovery of thousands of genes from microbes, phages and metagenomic samples. The platform demonstrably faster, quantitative, economical and simpler compared to existing workflows. -Developed a systematic experimental workflow for discovery of host-phage interaction determinants important in manipulation of microbial communities, and engineering of phage resistant bacterial strains crucial in bioprocesses like Dairy industry- Engineering genetic tools for reliable gene expression in phylogenetically diverse microorganisms - Engineering an universal synthetic biology platform for reliable expression of heterologous genes in E. coli discovered via functional genomics platform such as Dubseq (R & D 100 awarded tech)- Developing Design of Experiment approaches for optimizing the process of predictable expression of enzymes involved in metabolic pathways for producing high-value chemicals such as antibiotics, drugs and biochemicals.
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Co-FounderFelix Biotechnology Nov 2019 - PresentBiotherapeutics, Antibiotic resistant infections, Cystic Fibrosis, Bacteriophages
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InvestigatorInnovative Genomics Institute Jan 2017 - PresentBerkeley, California, Us -
Co-FounderPolyglot Biosciences Jan 2016 - Dec 2018Targeted interventions for modulating microbiomes and yielding therapeutic outcomes
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Team Leader @BiofabUniversity Of California, Berkeley Aug 2010 - Jul 2012Berkeley, Ca, UsThe BIOFAB: International Open Facility Advancing Biotechnology (BIOFAB) was founded in December 2009 as the world's first biological design-build facility under the leadership of Profs. Adam Arkin, Drew Endy and Jay Keasling. A joint effort between University of California, Berkeley, Stanford University, Lawrence Berkeley National Laboratory, BioBricks Foundation and Synthetic biology Engineering Research Center (SynBERC).BioFab projects are designed to produce broadly useful collections of standard biological parts that can be made freely available to both academic and commercial users, while also enabling the rapid design and prototyping of genetic constructs. • Developed Generalized ‘Expression Operating System’ that will be useful for designing and programming gene expression in a predictable manner at genome-scale engineering efforts • Managed multiple projects and professional staff in designing, building, and testing a collection of engineered genetic components that control constitutive RNA production, RNA processing and degradation, translation initiation, protein degradation and DNA replication in bacteria• Developed a method that allows for reliable functional coupling of prokaryotic transcription and translation control elements with user-specific coding sequences for genes of interest• Spearheaded the effort in designing, engineering and characterizing more than 300 promoters, 100 terminators, 150 translational coupling elements and more than 2000 element-element combinatorial libraries in E coli bacteria. • Lead predictive modeling approaches for uncovering sequence-activity relationships and developed multivariate data analysis pipeline -
Project ScientistBerkeley Lab Mar 2010 - Aug 2010Berkeley, Ca, UsWorked at Joint Bioenergy Institute (JBEI) to develop novel synthetic biology tools to regulate predictable protein expression with applications in bio-fuel research. • Developed a minimal complexity, maximally predictive data-driven sequence-activity model based on experimental dataset to design thousands of translation repressors and an entire panel of orthogonal regulators for reliable engineering of gene expression in E coli• The modeling approach is generally applicable to engineer other RNA elements
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Postdoctoral FellowBerkeley Lab May 2009 - Mar 2010Berkeley, Ca, UsSenior Postdoc fellow, Arkin Lab at Joint Bioenergy Institute. Main objective of this work was to devise methodologies to engineer transcription and translation processes to develop predictable protein expression systems. Worked in the field of Synthetic Biology and developed a family of orthogonal antisense RNA based translation regulators. Workplace: Joint BioEnergy Institute (JBEI); A six-institution partnership led by Lawrence Berkeley National Laboratory, JBEI is based in the San Francisco Bay Area, which is fast becoming a hub of renewable energy research and development. Research at the DOE Joint BioEnergy Institute (JBEI) is using the tools of synthetic biology to produce the next generation of biofuels
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Postdoctoral FellowUniversity Of California, San Francisco (Ucsf) Aug 2005 - Apr 2009San Francisco, California, UsWorked in Prof. Carol Gross's lab at the interface of computational biology and high throughput experimental quantitative biology. Objective was to develop sophisticated promoter prediction model from invivo and invitro transcription data on alternative transcription factor in E. coli. • High throughput experiments and multivariate data analysis techniques were used to obtain biophysical relationships between promoter activity of alternative sigma factors and promoter sequences• This is the first comprehensive study of complete target set of sigma factors -
ConsultantQb3 New Venture Consulting (Qnvc), Ucsf 2008 - 2009• Member of a consulting organization at UCSF that advises biotechnology start-ups founded on intellectual property invented in university laboratories • Worked with a team of 7 graduate students and post-docs to identify the market opportunity, market entry, and FDA regulatory policies for a start-up developing an anti-microbial surface coating for medical devices• Conducted thorough analysis on various market sizes, trends, drivers, competition, and pricing. Created a mathematical model to uncover the relationship between pricing and efficiency of antimicrobial coating.
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Phd In Chemical Engineeing (Systems Biology)Indian Institute Of Technology, Bombay (Iitb) Jul 2000 - Jul 2005PhD thesis: " Quantification of biological signaling and regulatory networks"; Thesis Supervisor and Mentor: Dr. KV Venkatesh; This award winning work explains how to quantify the input-output performance of biological regulatory systems, to analyze emergent properties like, signal amplification, robustness, sensitivity of the response and to uncover the regulatory design principles involved. Work involved building mathematical models of biological regulatory networks.
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Senior Fermentation ExecutiveWockhardt Enterprise (Merind Limited), Mumbai, India Dec 1998 - Jul 2000Mumbai, InCoordinated and supervised a team of technicians in Vitamin-B12 Fermentation department. Experience in handling large scale fermentation of capacity 100 KL. Responsibilities included training operators, reviewing batch records, writing SOP’s, man power management, coordinate with R & D department, analyzing fermentation profile, reporting to production manager and coordinating with other utility departments. -
Fermentation ExecutiveTorrent Gujarat Biotech Ltd (Tgbl), Baroda, India Jun 1997 - Dec 1998Supervised day-to-day activities of fully automated Penicillin G Fermentation plant. Experience in handling large scale fermentation of capacity 150 KL. Worked as part of a team managing GMP activities in the Production area as well as developing and overseeing production schedules and material / resource requirements
Vivek Mutalik Skills
Vivek Mutalik Education Details
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Indian Institute Of Technology, BombayChemical Engineering (Systems Biology) -
University Of MumbaiBioprocess Technology (Udct)
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Karnatak UniversityBelgaum)
Frequently Asked Questions about Vivek Mutalik
What company does Vivek Mutalik work for?
Vivek Mutalik works for Berkeley Lab
What is Vivek Mutalik's role at the current company?
Vivek Mutalik's current role is Staff Scientist & Principal Investigator at Berkeley Lab.
What is Vivek Mutalik's email address?
Vivek Mutalik's email address is vi****@****hoo.com
What schools did Vivek Mutalik attend?
Vivek Mutalik attended Indian Institute Of Technology, Bombay, University Of Mumbai, Karnatak University.
What are some of Vivek Mutalik's interests?
Vivek Mutalik has interest in Com/vivek_mutalik, Https, Twitter.
What skills is Vivek Mutalik known for?
Vivek Mutalik has skills like Biochemistry, Bioinformatics, Molecular Biology, Systems Biology, Biotechnology, Synthetic Biology, Computational Biology, Microbiology, Life Sciences, Metabolic Engineering, Protein Expression, Protein Chemistry.
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