Christopher Waddling Email & Phone Number

San Francisco Bay Area

San Francisco Bay Area

San Francisco Bay Area

San Francisco Bay Area

PROFESSIONAL EXPERIENCEResponsible for day-to-day management of a 150-client, 30-lab supported core facility with an annual operating budget of over $250000; graduate-level lab course; grant writing; policy-making; software and equipment; crystallography community-building; crystallography research.Highlights:· X-ray Facility Management: build relationships in local crystallography community; management and policy initiatives and improvements quadrupled the UCSF Crystallography Facility client base; positively impacted the learning environment and quality of scientific study; increased Facility throughput; direct and advise on grant applications for new equipment and salary support; implemented acquisition of state-of-the-art technological advances; manage cooperative agreements with private sector; maintain Crystallography Facility equipment, software, and web site.· Teaching and Training: Initiate, develop, and teach the practical section of two graduate-level crystallography courses; on-going training of all users of our facility's equipment at UCSF and at the Advanced Light Source at the Lawrence Berkeley National Labs.- Maintain relationships with equipment and software specialists in crystallography to remain current with the state of the art in our and related fields· Research: experienced in protein crystallization, optimization and data collection, refinement, and structure solution; experienced at analyzing the structural and functional properties of proteins and exploring their interactions with ligands, inhibitors, and therapeutic small molecules.· Experienced user of the ALS synchrotron beamlines (SAD, MAD) and rotating anode x-ray equipmentRESEARCH AWARDS AND GRANTS08/2008 – 08/2009 QB3 UCSF 08-09 R1 Award Salary support for James Holton (UCSF/ALS) and Chris Waddling (UCSF) $75,000 04/2006 – 04/2007 NIH Shared Instrument Grant Proposal Role: Grant coordination, consultant, and equipment staff person $280,353

Albany, New York Area

Involved in the determination of several crystal structures, including a high-resolution structure of the peptide-N-acetyl glycoamidase F mutant in complexation with its glycopeptide substrate; the endoglucosidase Endo F3 and complexes with its products; a deletion mutant of human thymadylate synthase complexed with dUMP and the antifolate drug Tomudex; and a novel intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate.Became familiar with macromolecular crystallization techniques and the use of in-house macromolecular crystallography data collection instrumentation, software, and structure solution and refinement protocols.

Bachelor Of Science (B.Sc.), Chemistry & Physics Double Major

M.Sc., Chemistry

I specialized in reaction mechanisms of inclusion complex formation using alpha-cyclodextrin.

Phd, Chemistry

I focused on the synthesis, kinetics, and structural determination of inclusion complexes of a cyclic pyrimidiniophane.

Spanish Language