Wade Self, Ph.D. Email & Phone Number

St. Louis, Mo, Us

St. Louis, Mo, Us

St. Louis, Mo, Us

• Scholar under the mentorship of Dr. David Holtzman• Leading a translational research team that aims to understand the mechanisms by which gut microbiota contribute to Alzheimer Disease pathogenesis utilizing transgenic mouse models, raised in specific pathogen free and gnotobiotic conditions, and human fecal samples from individuals living with AD.• Leading a collaboration with a biotechnology company to understand how experimental therapeutics modify AD-associated pathologies in transgenic mouse models.

Chicago, Il, Us

• Led a research team to identify the mechanisms by which the gut microbiome influences the onset and progression of Alzheimer’s Disease pathology in transgenic animal models under the mentorship of Dr. Sangram Sisodia.• Collaborated with a pre-market pharmaceutical company to test small molecules which target the peripheral immune system in preclinical models of Alzheimer’s Disease.

North Chicago, Illinois, Us

• Led the ideation and development of new target-binding and pharmacodynamics biomarker assays for therapeutics targeting tau protein in Alzheimer’s Disease and Primary Tauopathies• Developed personal relationships with biomarker scientists and senior leadership within DMPK and Clinical Development at Ludwigshafen, Germany and North Chicago, Illinois to more efficiently drive tau biomarker projects towards clinical development in compliance with FDA guidance• Communicateed science in biomarker method validation reports and presentations at scientific conferences• Identified and initiated experimental collaborations with key tau biology scientific leaders within AbbVie Discovery Neuroscience at Cambridge, Massachusetts to generate key data for preclinical candidate nomination• Served as an AbbVie project representative for the Center for Protein Therapeutics at SUNY-Buffalo to provide scientific consultation and communicate project team research findings to DMPK leadership• Led event planning and identification of learning development opportunities for AbbVie Postdoctoral Research Fellows as the AbbVie Postdoctoral Program Education Committee Chair

• Led team of mobile application developers and teachers to design and create products for middle school STEM classrooms focused on neuroscience and brain education. Piloted prototype material with 200+ students in St. Louis Public School Districts. • Developed profitable business model (33% Profit Margin) that connects students to subject-matter experts for online learning.

St. Louis, Missouri, Us

• Performed primary interviews with therapeutic area key opinion leaders and prepared investments reports to analyze prospective medical device and biotechnology companies for seed-stage investment • Researched emerging trends and innovative technologies in the pharmaceutical, biotechnology, and health care information technology industry to identify potential investment leads

St. Louis, Mo, Us

• Awarded $90,000 in funding over 3 years for training in clinical and translational science through research, didactic coursework, works in progress research discussions, journal clubs, and presentations at conferences (3). • Relevant Coursework: Drug and Device Development, Statistics for Clinical Research, Designing Outcomes for Clinical Research • Clinical Research Training Center Outstanding Citizenship Award, May 2017, awarded to one student in the TL1 Predoctoral Clinical Research Fellowship in recognition of outstanding achievement in the program

St. Louis, Mo, Us

• Thesis Advisors included Dr. Timothy Miller, a world leader in amyotrophic lateral sclerosis drug development, and Dr. Randall Bateman, a world leader in clinical Alzheimer's Disease investigations.• Communicated research in amyotrophic lateral sclerosis drug development through scientific publication in high-impact journals (3), presentations at international conferences (6), and authoring grants totaling $1,500,000+ for the laboratory• Managed a cross-functional team of R&D scientists at two biotechnology companies, scientists in 3 academic research groups, and clinical research coordinators at 2 medical centers to perform a clinical study in human ALS patients (NCT03449212) • Developed protein-based biomarkers in cerebrospinal fluid to assay pharmacodynamics of RNA-targeted therapies for ALS and Alzheimer disease

St Louis, Mo, Us

• Guided organizational strategy and personally mentored 20+ consultants and project managers over 6 engagements• Primary manager of company website, project management software, and document curation for 40+ consulting projects • Created new standardized processes for all project managers to increase efficiency organization-wide, including novel feedback mechanisms for consultants and time management tools to monitor weekly team member workload • Managed five-person teams of PhD scientists across multiple scientific disciplines by designing research objectives, organizing and leading team meetings, and communicating with clients across 4 projects• Completed 2 projects in go-to-market business strategy for clients in pharmaceutical drug development (neurology, antimicrobial)•

Cleveland, Oh, Us

• BME 105: Introduction to Biomedical Engineering • Held office hours for student questions and review of course material

Cleveland, Oh, Us

• Volunteer Undergraduate Researcher in the Laboratory of Dr. Jeffrey Capadona in the Department of Biomedical Engineering. • Investigated modulators of chronic neuroinflammation associated with intracortical microelectrode implantation for functional electrical stimulation (FES).• Authored 2 scientific publications and received research fellowship grants at CWRU and the Mayo Clinic Totaling $10,000

Rochester, Minnesota, Us

• Fellow in the laboratory of Dr. Guojun Bu, Ph.D. in the Department of Molecular Neuroscience. • Project focused on identifying natural compounds that modulate Apolipoprotein E production in astrocytes.

Doctor Of Philosophy (Ph.D.), Neuroscience

Bachelor Of Science (Bs), Magna Cum Laude, Biomedical/Medical Engineering

High School Diploma