Don Walker Email & Phone Number

Canterbury, United Kingdom

Expertise in preclinical drug metabolism and pharmacokinetics in support of drug discovery and development. Established author of scientific papers and regulatory submission documentation.

Scientific Leader for Europe for Development Strategies Group within Pharmacokinetics, Dynamics and Metabolism. Group has responsibility for ensuring high quality science in support of the PGRD development portfolio and proactive engagement with regulatory bodies to align our scientific strategy and facilitate drug registrations.

Group Manager for DMPK Groups for Preclinical Development and BioanalysisLed Preclinical Development Group between 2002 and 2005, managing a group of ~12 scientists involved in studying metabolism and disposition of drug development candidates in animal species and man. Member of global discipline board to establish best practices, advance metabolism and pharmacokinetic science and ensure awareness of regulatory expectations.Led bioanalytical group between 2005 and 2008, managing group of ~ 30 scientists involved in bioanalytical work to support drug discovery and development programs. Responsible for GLP bioanalytical function in support of toxicokinetic sample analysis and PK from early clinical studies. Member of departmental management team and global discipline board for DMPK science.

Laboratory scientist involved in the generation of in vivo and in vitro metabolism and pharmacokinetic data from preclinical and clinical studies. Developed fit for purpose bioanalytical assays fro drug discovery and drug development programs using HPLC and radioimmunoassay techniques. Interpretation of data using pharmacokinetic analysis and member of drug discovery and drug development project teams as departmental representative. Development of role included growing team leader responsibilities involving training and development of junior scientists.

Working in Developmental Neurobiology Unit. Research involving the analysis of various endogenous markers that may be involved in Down's Syndrome using techniques including TLC and GC

Research Assistant in group conductung research into Inborn Errors of Metabolism. Work involved analysis of urine, plasma and tissues samples for organic and amino acids for the detection of inborn errors of metabolism. Techniques used included liquid-liquid extraction, solid phase extraction, TLC, GC and HPLC (amino acid analyser).