Walter Knight work email
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Walter Knight personal email
Research scientist specializing in cardiovascular and stem cell biology. 10+ years of experience with wet lab skills, including CRISPR/Cas9 genome editing, developing high throughput screening-based approaches, creating stem cell-based models of heart failure, and working with animal models of heart failure. Significant experience with data analysis, including RNA-seq datasets. Highly motivated scientist, works well both independently and conducting team science and collaborations. Significant experience with both the design and execution of scientific projects. Robust publication record, including multiple first author publications from both graduate school and postdoctoral fellowship.Strong track record of attaining external funding, including highly competitive fellowships from the American Heart Association. Significant experience in scientific writing, including manuscript design and preparation. I write my own papers, and regularly peer review for a number of scientific journals. Passionate about developing new systems to characterize heart failure, and if possible, pioneering new therapeutic approaches.
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Associate Principal ScientistBayerBoston, Ma, Us -
Senior ScientistBristol Myers Squibb May 2023Lawrence Township, Nj, Us -
Senior Scientist IiInscripta, Inc. Mar 2023 - May 2023Pleasanton, California, UsWorked on a small team to develop novel approaches to mammalian gene editing by combining state-of-the-art techniques with Inscripta's existing MADzyme technology. • Developed and integrated new editing workflows within a matter of months• Brought new editing approaches into the group from ideation to execution• Required deep understanding of salient gene editing literature• Worked on a small team in a fast-paced environment -
Senior ScientistInscripta, Inc. Mar 2022 - Mar 2023Pleasanton, California, UsWorked within a large team developing a novel product relevant to the mammalian genome engineering space. • Developed and optimized high-throughput mammalian editing protocols• Tested and optimized multiple editing workflows• Conducted experimentation and analysis under tight deadlines• Presented results and drove/informed decision making to stakeholders within program on a frequent basis
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Postdoctoral FellowUniversity Of Colorado Anschutz Medical Campus Nov 2016 - Mar 2022Aurora, Co, UsThe focus of my postdoctoral fellowship has been to develop protocols for use of human stem cell derived cardiomyocytes (hiPSC-CMs) to model cardiovascular disease in the petri dish, and use these approaches to identify novel disease mechanisms and treatment strategies. Specific projects: • Developed a combination of methods to improve maturity in human stem cell derived cardiomyocytes (hiPSC-CMs) producing adult-like cardiac cells (findings published in January 2021). • Using CRISPR-Cas9 mutation strategies, created an hiPSC-CM based model of the cardiac disease hypertrophic cardiomyopathy (HCM). Now, focused on phenotypically characterizing HCM in human cardiac tissue and hiPSC-CMs. • Using gene edited hiPSC-CMs, developing high throughput screening approaches to uncover novel treatment strategies for HCM.• Research supported by AHA Postdoctoral Fellowship from 2019-2020.• Research supported by CCTSI Co-Pilot Award in 2019-2020. -
Graduate StudentUniversity Of Rochester School Of Medicine And Dentistry Sep 2009 - Sep 2016Rochester, New York, UsI lead and developed a project characterizing the role of the protein phosphodiesterase 1C (PDE1C) in heart failure. We found that by degrading the small molecule cAMP, PDE1C regulates protective signaling mediated by cardiac adenosine A2 receptors. In heart failure, increased expression of PDE1C blocks this protective signaling, leading to cardiomyocyte cell death, cardiac hypertrophy, and fibrosis. Conversely, pharmacologically inhibiting or genetically deleting PDE1C is highly protective in heart failure. Although this work was conducted primarily in mouse models, PDE1C is highly expressed in human heart, and is indeed upregulated in human heart failure, making a potentially attractive therapeutic target. In conducting this project, I gained expertise in project planning, grant and scientific writing, and collaborated with a number of peers both in my lab and in other labs and institutions. -
Undergraduate ResearcherNoaa: National Oceanic & Atmospheric Administration May 2008 - Aug 2008Washington, Dc, UsI used mass spectrometry-based approaches (specifically MALDI-TOF) to innovate approaches for detecting the inflammatory marker C-reactive protein, CRP. CRP is thought to be a potentially important biomarker for the health of marine environments, consequently developing approaches to allow for its rapid quantification from samples would be useful.
Walter Knight Education Details
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University Of RochesterMolecular Pharmacology -
Cornell UniversityChemistry & Biochemistry (Double Major)
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Cornell UniversityChemistry And Biology/Biochemistry (Double Major)
Frequently Asked Questions about Walter Knight
What company does Walter Knight work for?
Walter Knight works for Bayer
What is Walter Knight's role at the current company?
Walter Knight's current role is Associate Principal Scientist.
What is Walter Knight's email address?
Walter Knight's email address is wa****@****pta.com
What schools did Walter Knight attend?
Walter Knight attended University Of Rochester, Cornell University, Cornell University.
Who are Walter Knight's colleagues?
Walter Knight's colleagues are José Luis Larriba Teodoro, Daniel Pacheco, Amit Kapoor, Guilherme Souza Santos Alencar, Tetiana Panfilenko, Cody Nelson, Rachel Calcutti.
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