Warren D'Souza Email & Phone Number

Alameda, California, Us

Head of Search and Evaluation

New York, New York, Us

Oncology search and evaluation, Licensing and Academic partnerships for Pfizer Oncology R&D, Pfizer's Centers for Therapeutic Innovation and Pfizer Ventures

Thousand Oaks, Ca, Us

Global Lead Search and Evaluation Immuno-Oncology: lead for all pre-clinical, clinical and commercial stage collaborations and partnerships; lead for diligence on Research, Development, CMC, IP and Regulatory; member of Amgen's Oncology Franchise Steering Committee

Thousand Oaks, Ca, Us

Search and Evaluation in Oncology

Thousand Oaks, Ca, Us

• Discovery efforts in IBD, other autoimmune/inflammatory diseases and immuno-oncology• Led program that targets Teff cell metabolism in autoimmune diseases• Led IBD program targeting a molecule involved in immunomodulation and microbial clearance• Evaluation of new discovery targets in IBD and immuno-oncology• Led program targeting intestinal microbiome regulation and epithelial barrier function• Led program targeting proinflammatory cytokine production & stability in immune cells• Led a discovery program for an orphan C class GPCR in OA• In vivo lead for a late-stage large molecule program in IBD• In vivo lead for a mid-stage large molecule program in OA• Validation studies for potential licensing opportunity• Evaluation of CROs for animal models• Collaborations with academic investigators

Thousand Oaks, Ca, Us

• Discovery efforts in autoimmune and inflammatory diseases• Led a discovery effort targeting a Ser/Thr kinase implicated in TLR and TCR signaling• Flow-cytometry based human whole blood assay to screen compounds for an asthma program• Murine & human lymphocyte assays for a small molecule drug candidate in SLE• Set-up and validated the MMT, intra-articular IL-1b and MIA models of OA• Investigated novel PD and biomarker readouts in OA models• Use of novel strategies to prolong the retention of large molecules in the knee joint• Determination of PK and retention of large molecules following IA injection• Development of assays to measure hyperalgesia and allodynia in rodent OA

La Jolla, Ca, Us

• Analyses of the cellular parameters regulating T cell expansion, contraction and memory formation using in vivo animal models of viral and bacterial infections• Identification of the molecular mechanisms involved in T cell activation, proliferation and death; specifically with regard to ERK MAPK signaling cascade and the Bcl-2 family of proteins***Recipient of the Leukemia Lymphoma Society Fellowship Award (2005-2008)

Farmington, Connecticut, Us

Investigation of the role for cytokines such as Interleukin-2 in regulating the proliferation, survival/death, and effector function of T cells in response to:1. viral and bacterial infections,2. self-antigens (under conditions of autoimmunity/tolerance), and3. tumor-derived antigens***Recipient of Henderson award for "Outstanding Doctoral Thesis"

Certificate In Advanced Management

Ph.D., Immunology / Biomedical Sciences

M.S., Life Sciences