We are developing new synthetic methods tha enables chemist to make silicon containing organic compounds.We examine the possible application of silicon containing compounds in early drug discovery, including using 29Si as a biophysical probe, as well as fluorescent organosilicons.We apply Fragment-Based Lead Discovery toward the development of probe compounds to interrogate novel therapeutic proteins.

Engaged in drug discovery based on novel targets identified by Gene-Knockout techniques.

Engaged in the identification of new therapeutical molecular target using chemistry tools.

Engaged in the development of new synthetic methodologies and their application in natural product total synthesis