Weiwei Lin Email & Phone Number

Boston, Ma, Us

Boston, Ma, Us

Boston, Ma, Us

Experienced analytical biochemist with 7+ years in proteomics and metabolomics. Solid background in protein-protein interaction networks induced by Alzheimer’s disease. Hands-on experience with developing, optimizing, and applying mass spectrometry.Project Lead(1) Discovery of pathology-associated changes in the cellular protein-protein interaction networks and macromolecular complexes induced by Alzheimer’s disease. * (Phospho)proteomic analysis using state-of-art MS and bioinformatic techniques. * First large-scale native protein complexes mapping tauopathy-associated AD progression.(2) Development of an integrated metabolomic and proteomic profiling platform to study the potential biomarkers in end-stage kidney disease patients. * Reproducible, high sensitivity workflow in parallel with minimal sample consumption. * First integrated platform enables nano-flow LC/MS for metabolomics.Skills(1) Multi-omicsBottom-up Proteomics | TiO2 & IMAC Phosphopeptide Enrichment | Immunoprecipitation MS |Native Protein-protein Interaction | Untargeted & Targeted Metabolomics | Lipidomics(2) Analytical BiochemistryLC-MS Method Development & Optimization | HPLC (reverse/normal phase, ion-exchange) |Peptide Fractionation | DDA | PRM | DIA | TMT| PTM | FAIMS | Solid Phase Micro-extraction(3) Data Analysis R-based Proteomic & Metabolomic Data | Normalization | Batch Correction | Differential Analysis | WGCNA Analysis| GSEA Enrichment | PPI Prediction | Maxquant | Visualization (heatmap, volcano plot, PCA, Photoshop, Illustrator) | Cytoscape (EM, String) Interests Semi-professional Badminton Player | Tennis Beginner | Terrible at Smash Bro