I have a broad background in biomedical research and extensive hands-on experience with biochemical and molecular technology, preclinical drug development, and small animal models of various human diseases. My current research interests focus on studying the molecular mechanisms of radiation-induced organ injury including immune dysfunction, inflammation, senescence, and fibrosis. I am also working on developing radiation medical countermeasures to treat acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). My previous research areas include studying different cell death mechanisms (apoptosis, necroptosis, and pyroptosis), the role of immune cells (macrophages, neutrophils, and iNKT cells), and energy metabolism pathways attributed to the organ injury under ischemia-reperfusion, hemorrhagic shock, and sepsis. I also studied the role of bone morphogenetic protein signaling in regulating colorectal cancer progression and metastasis as well as cellular responses to surgical cryo- and radiofrequency ablations in solid tumors. In addition to academic, I had been served as Chief Scientific Officer of a biotech start-up company (part-time). I led several preclinical studies to develop new therapeutic agents for acute kidney injury, inflammatory bowel disease (IBD), sepsis, and ARS, and to test the efficacy, pharmacokinetics, and toxicity of several drug candidates. I raised more than $7.6 million from NIH SBIR awards.I have published more than 100 peer-reviewed papers in cancer, critical care, and radiation research areas. I am an associate editor of Molecular Medicine and frequently serve as a scientific reviewer for DoD grant proposals. I have served as Principal Investigator or Co-Investigator in more than 18 NIH academic and industrial grants. I have mentored more than 30 trainees, including postdoctoral fellows, surgical residents, PhD candidates, and medical, college and high school students. Most of them have presented their works and received awards from local and national scientific societies.