William Herrick

William Herrick Email and Phone Number

Scientist II at Leidos Biomedical Research/Frederick National Laboratory @ Leidos Biomedical Research, Inc.
Washington, DC, US
William Herrick's Location
Washington DC-Baltimore Area, United States, United States
William Herrick's Contact Details

William Herrick work email

William Herrick personal email

About William Herrick

I am a scientist in the Clinical Pharmacodynamics Biomarker Program at the Frederick National Laboratory, where I develop novel, quantitative sandwich immunoassays on the Luminex platform to support pharmacodynamics research in NCI-sponsored clinical trials. My interests are in the development and validation of assays and antibodies, the pharmacodynamics of molecularly-targeted therapies, and the development of industrial bioprocesses (e.g. cell culture processes).

William Herrick's Current Company Details
Leidos Biomedical Research, Inc.

Leidos Biomedical Research, Inc.

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Scientist II at Leidos Biomedical Research/Frederick National Laboratory
Washington, DC, US
Employees:
606
William Herrick Work Experience Details
  • Leidos Biomedical Research, Inc.
    Leidos Biomedical Research, Inc.
    Washington, Dc, Us
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  • Leidos Biomedical Research, Inc.
    Scientist Ii
    Leidos Biomedical Research, Inc. Sep 2022 - Present
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  • Leidos Biomedical Research
    Scientist I
    Leidos Biomedical Research Mar 2018 - Sep 2022
  • Leidos Biomedical Research
    Postdoctoral Fellow
    Leidos Biomedical Research Oct 2015 - Feb 2018
    I am a postdoc fellow in the Pharmacodynamics Assay Development & Implementation Section (PADIS) at the Frederick National Laboratory (NCI-Frederick) conducting Luminex multiplex assay development in the area of MEK/ERK and PI3K/AKT signaling. The position is challenging but also rewarding, as it provides an inside-look at cancer drug development and clinical trial design at the NCI. I am also excited that my assays will someday be used to aid in the development of more effective drugs and therapies by providing critical pharmacodynamic information and drug resistance mechanisms for NCI-sponsored clinical trials.My primary responsibilities include monoclonal antibody development to generate highly specific antibody reagents and all aspects of Luminex assay development. Other critical duties include the screening and validation of commercial antibody reagents, generation of validation materials from in vitro cell culture models, selection of recombinant protein standards for assay calibrators, reagent scale-up, and assay fit-for-purpose validation. Details of major responsibilities:Monoclonal Antibody Development: - Design of immunizing peptides - Screening of animal test bleeds and hybridoma supernatants for desired specificity and optimal affinity - Antibody purification by Protein A/G affinity chromatography - Assessment of antibody candidates in Luminex assaysLuminex Assay Development: - Development and selection of antibody and recombinant protein reagents - Antibody coupling to Luminex bead reagents - Antibody biotinylation - Assay optimizations including buffer selection, detection and capture antibody titration, standard curve range, and sample preparation (with major considerations to pre-analytical variables) - Assay validation including assessment of spike-recovery, cross-reactivity, specificity, dilutional linearity, reagent stability, inter- and intra-assay precision
  • Mathnasium - The Math Learning Center
    Instructor
    Mathnasium - The Math Learning Center Nov 2014 - Oct 2015
    Los Angeles, Ca, Us
    During the time between finishing graduate school and starting my current postdoc position, I was a part-time after-school math instructor at the Mathnasium in Mendham, NJ. My role was to work with students (K-12) 1-on-1 in a group setting to teach them fundamental and practical concepts from numerical fluency and problem solving to more advanced math topics including geometry, trigonometry, pre-calculus, AP calculus, and SAT prep. Despite having little prior teaching experience I was able to quickly master the tools, strategies, and techniques needed to effectively teach students of all ages and skill levels. It was an extremely rewarding experience and I will miss it!
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  • University Of Massachusetts Amherst
    Graduate Research Assistant
    University Of Massachusetts Amherst Jul 2008 - Mar 2015
    Amherst, Massachusetts, Us
    With my original adviser, I engineered an enzyme with the long term goal of producing a quorum sensing yeast for autoinduced production of biopharmaceuticals: • Engineered a variant of the enzyme LuxI with directed evolution and selection to broaden substrate specificity.• Demonstrated with a cellular assay and HPLC-MC that our novel enzyme variant produced a wider variety of signaling molecules.• Functionalized this variant in yeast (S. cerevisiae) by inducing mitochondrial import with a genetically-encoded targeting sequence, required because mitochondria are related to bacteria and contain the necessary enzymatic substrates. • Verified that mitochondrial import was necessary and sufficient for activity in yeast by expressing a custom fusion protein in S. cerevisiae and confirming production of the signaling molecules with a cellular assay.After my original adviser relocated, I joined an innovative new lab, where we develop useful biomaterials and study how cell-microenvironment interactions impact disease: • Developed and characterized a novel PEG-based hydrogel with exceptional mechanical properties (~1 - 10,000 kPa Young's modulus), fouling properties, and optical transparency.• Applied this material to a mechanobiology study investigating the effects of substrate stiffness on proliferation and adhesion of multiple cancer cell types. (Herrick et al 2013)• Developed an in vitro model featuring multiple physical and chemical factors to investigate their roles in the phenotype plasticity of smooth muscle cells and disease-relevant behaviors including proliferation and motility. Requirements included extensive mammalian cell culture, numerous immuno (xMAP, Westerns, IHC/IF) and cellular (proliferation, viability) assays, microscopy, and more. (Herrick et al 2015)• Juggled multiple lab management duties including initial start-up, the training of new students, supply ordering, and the ordering, setup, and evaluation of new lab equipment.
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  • Johns Hopkins University
    Undergraduate Research Assistant
    Johns Hopkins University Sep 2006 - May 2008
    Baltimore, Md, Us
    • Worked in a clean room and fabricated microfluidic devices with techniques including photomask patterning of photoresist, chemical etching, profilometer characterization, PDMS curing, and oxygen plasma binding.• Used CAD software to design microfluidic device patterns for photomasks.• Tracked the size-based separation of fluorescently-labeled polystyrene microbeads in custom microfluidic devices with microscopy and automated tracking software.
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  • Johns Hopkins University
    Information Systems Support Tech
    Johns Hopkins University Sep 2004 - May 2008
    Baltimore, Md, Us
    • Responsible for responding to user help requests, installing new hardware, imaging new PCs for users, and other routine IT support tasks. • Excelled at technical problem solving, with no problem encountered left unsolved. • Implemented strategies to streamline and optimize workflow, such as imaging several PCs at a time with a local network, instead of 1 at a time.
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  • Medical Rehabilitation Associates
    Administrative Assistant And Medical Transcriptionist
    Medical Rehabilitation Associates Jul 2002 - Aug 2004
    • Administrative assistant responsible for accounts payable, balancing checkbook, contacting vendors as needed, etc. • Transitioned into a medical transcription role where I both transcribed medical reports and developed Microsoft Word VBA applications to streamline procedure reporting.

William Herrick Skills

Chromatography Chemical Screening Winter Ice Chemistry Import Windows Bacterial Undergraduate Matlab Students Evolution Atherosclerosis Gst Coupling Proliferation Collecting Symposium Pdms Particle Rna Mammalian Microfabrication Solvent Extraction Yeast Fluorometer Mammalian Cell Culture Disease Cancer Extracellular Matrix Mechanobiology Lithography Bioconjugation Management German Cellular Communications Funding Smc Statistics Sensitivity Materials Science Bioengineering Nanotechnology Synthetic Grc Office Equipment Immunoassays Gel Publications Linux Hplc Doi Sun Microsystems Enzyme Activity Image Analysis Pcr Cell Education Photography Baltimore Engineering Muscle Subcloning Tissue Engineering Fluorescence Inventory Complexity Microsoft Office Revision Process Control Aseptic Technique Biochemical Engineering Training Modulation Cell Based Assays Clean Rooms Fabricated Nsf Conferences Rt Pcr Directed Evolution Supply Protein Purification American Research Process Engineering Talk Adenovirus Wave Energy Analysis Molecular Imagej Microscopy Laboratory Nucleic Acid R Cell Lines C Western Blotting Affinity Transfection Recombinant Dna Computer Repair Chemical Engineering Applications Voice And Data Convergence Home Modeling Protein Conjugation Arterial Dna Cell Culture Mechanical Properties Mimics Immunofluorescence Baculovirus Scientific Graphpad Prism Imaris Characterization Purification Posters Molecular Biology Luminex Beads Bacterial Cell Culture Sap Xi Data Driven Testing Measurements Molecular Cloning Biochemistry Soft Lithography Uv/vis Spectrophotometry Presentations Hplc Ms Linkedin Bioreactor Google Groups Elisa Gel Electrophoresis Computer Hardware Biomaterials Expression Dialysis Integrative Statistical Data Analysis Fermentation Java Resistance Bioassay Viability Mathematical Modeling Separation In Vitro C++ Platforms Versatile Python Electrophoresis Fluorescence Microscopy Insect Vector Nti Tissue Culture Signalling

William Herrick Education Details

  • University Of Massachusetts Amherst
    University Of Massachusetts Amherst
    Chemical Engineering
  • The Johns Hopkins University
    The Johns Hopkins University
    Chemical And Biomolecular Engineering
  • Bates College
    Bates College

Frequently Asked Questions about William Herrick

What company does William Herrick work for?

William Herrick works for Leidos Biomedical Research, Inc.

What is William Herrick's role at the current company?

William Herrick's current role is Scientist II at Leidos Biomedical Research/Frederick National Laboratory.

What is William Herrick's email address?

William Herrick's email address is he****@****dos.com

What schools did William Herrick attend?

William Herrick attended University Of Massachusetts Amherst, The Johns Hopkins University, Bates College.

What are some of William Herrick's interests?

William Herrick has interest in Social Services, Economic Empowerment, Civil Rights And Social Action, Politics, Education, Poverty Alleviation, Science And Technology, Human Rights, Health.

What skills is William Herrick known for?

William Herrick has skills like Chromatography, Chemical, Screening, Winter, Ice, Chemistry, Import, Windows, Bacterial, Undergraduate, Matlab, Students.

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