-Lead Process Centric Team (PCT) for the assigned production trains/products. Setting the budget for the product (Product Costing and Volume) and meeting the annual production volumes-Lead, direct and coach the Process Engineers team, including developing and communicating objectives, setting priorities, development plans and managing performance.-Support production planning, process optimization, and monitor and control production inventory levels to optimize materials usage and… Show more -Lead Process Centric Team (PCT) for the assigned production trains/products. Setting the budget for the product (Product Costing and Volume) and meeting the annual production volumes-Lead, direct and coach the Process Engineers team, including developing and communicating objectives, setting priorities, development plans and managing performance.-Support production planning, process optimization, and monitor and control production inventory levels to optimize materials usage and minimize waste.-Collaborate with cross-functional teams (engineering, supply chain, quality, etc.) to ensure alignment and coordination throughout the production cycle. -Create and maintain updated technical documents (batch records, FMEA, PPQs, validation reports) liaising with operations, automation, and QA with emphasis on safety & quality-As part of continuous improvement plan (CIP), identified and implemented opportunities to improve process performance and operations -cycle time. -Supported investigations/ regulatory audits, identified the root cause, and put robust CAPA for manufacturing deviations, human errors and equipment related issues. Show less

-Joined biotech start-up a biotechnology company focusing on developing drugs targeting age-related diseases-Hiring and developing research staff & setting up new facilities -Strategic planning, Development of new IP & Advancing siRNA & small molecules therapeutics programs into clinic through drug discovery and development process

-Responsible for Tech transfer- new product Introduction, and process harmonization across global manufacturing units with emphasis on safety-Responsible for development/training of process engineers, process chemists and analytical chemists solve recurring issues in manufacturing-Provide technical support to manufacturing units including owned, tolled and suppliers to maintain the technical know-how in terms of process safety, yield, and quality-Work directly with manufacturing… Show more -Responsible for Tech transfer- new product Introduction, and process harmonization across global manufacturing units with emphasis on safety-Responsible for development/training of process engineers, process chemists and analytical chemists solve recurring issues in manufacturing-Provide technical support to manufacturing units including owned, tolled and suppliers to maintain the technical know-how in terms of process safety, yield, and quality-Work directly with manufacturing units and Tech. Center to identify and implement improvements on safety, asset utilization, yields and costs-Lead Intellectual Property (IP) & brand protection initiatives of block buster assets-Provide process/product data analyses supporting strategic business, registrations, and supply chain decisions Show less

-Joined AbbVie Singapore start-up. Retro-fitted old acquired MSD plant for launching AbbVie products and successfully automated the manufacturing process by migration of semi manual ABB to fully automated DCS Delta-V system -Hired & managed 12 technical staff comprising of Chemists/Engineers and set up fully functional potent API support Lab. -Liaised with global network of manufacturing sites/R&D/MS&T and served as knowledge hub sharing Product/Process performances. Advanced… Show more -Joined AbbVie Singapore start-up. Retro-fitted old acquired MSD plant for launching AbbVie products and successfully automated the manufacturing process by migration of semi manual ABB to fully automated DCS Delta-V system -Hired & managed 12 technical staff comprising of Chemists/Engineers and set up fully functional potent API support Lab. -Liaised with global network of manufacturing sites/R&D/MS&T and served as knowledge hub sharing Product/Process performances. Advanced the site Technical Operations function at par with global R&D and gained recognition/ reputation as site of excellence.-Harmonized the manufacturing processes at global network sites plugging engineering/process/quality/compliance gaps learn't from investigations/failures.-Led local site cross functional teams comprising of QA, QC, Engineering, Supply chain & Finance for cGMP timely manufacturing of key intermediates, final drug substance (API) and cleaning verifications/validations. -Tech transferred APIs from R&D/ network global manufacturing sites. Created manufacturing documents, supported failure mode analysis (FMEA) & EHS aspects. Post successful PPQ campaigns & process stabilizations, end of campaign cleaning and established robust track and trending.-Tracked and coordinated project milestones related to raw materials, equipment readiness, analytical testing, process information, and manufacturing documents to initiate and complete batches per the validation/production schedule. -Supported investigations, identified the root cause, and put robust CAPA for manufacturing deviations, human errors and equipment related issues. -Supported regulatory audits FDA/HSA/JAPAN -Trended process performances and established data analytics to serve as metrics, to assist in investigations, and as feedback for manufacturing and/or process optimization. -Identified and implemented opportunities to improve process performance and operations cycle time. Improved yields from 75% to 88% Show less

-Managed a group of 18 chemists. Introduced Spiro & BCP technology for drug discovery. -Developed patentable chemical series for Wnt & MNK kinase inhibitors with ETC-Developed new chemistry technology and alternate routes to existing products -Bridged discovery and applied research in the pharma sector whilst expanding the capabilities to strengthen the Science and Engineering Research Council (SERC) and the Biomedical Research Council (BMRC). -Supported… Show more -Managed a group of 18 chemists. Introduced Spiro & BCP technology for drug discovery. -Developed patentable chemical series for Wnt & MNK kinase inhibitors with ETC-Developed new chemistry technology and alternate routes to existing products -Bridged discovery and applied research in the pharma sector whilst expanding the capabilities to strengthen the Science and Engineering Research Council (SERC) and the Biomedical Research Council (BMRC). -Supported economy by anchoring companies in Singapore for job creation, adept returning A*STAR scholars and provide training/skill development.-As part of A*STAR-ICES initiative to bridge academia and Industry taught Medicinal Chemistry and Drug discovery courses from an industrial perspective to graduate students at NTU. Organized conferences between A*STAR ICES and NTU Chemistry staff. Tapped into A*STAR grants through joint grant proposals based on applied sciencesAccomplishments:1) Most inspiring mentor award for the year 2013-14 from A*STAR-ICES2) Outstanding reviewer awarded by American Chemical Society - Journal of Medicinal Chemistry 3) ACS publications editors award for highly cited article in 2011 in J. Med Chem. 4) Authored an Invited article by Chimia-A special edition showcasing Singapore-Swiss connections in chemistry and Chemical engineering (Acid mediated ring closing metathesis: A powerful synthetic tool enabling the synthesis of clinical stage kinase inhibitors. Chimia (2015), 69, (3), 142-1455) Invited Book Chapter by RSC : Designed macrocyclic kinase inhibitors. In Macrocycles in drug discovery. Royal Society of Chemistry: London, (2014), 141-205. Show less

-Joined S*BIO a Singapore Biotech start-up (Chiron & EDB)-Introduced small molecule marcocycles technology in drug discovery. -Served as a lead Chemist/ Inventor of 3 clinical stage compounds & managed a group of 15 people. -Led CMC activities of APIs-Tech transferred through CROs. -PPQ runs, GMP manufacturing API-Scaled & optimized the API to commercial scale (process validations)-Cleaning support 1) Pacritinib - JAK inhibitor developed by Cell… Show more -Joined S*BIO a Singapore Biotech start-up (Chiron & EDB)-Introduced small molecule marcocycles technology in drug discovery. -Served as a lead Chemist/ Inventor of 3 clinical stage compounds & managed a group of 15 people. -Led CMC activities of APIs-Tech transferred through CROs. -PPQ runs, GMP manufacturing API-Scaled & optimized the API to commercial scale (process validations)-Cleaning support 1) Pacritinib - JAK inhibitor developed by Cell Therapeutics for the treatment of Myelofibrosis. The drug is approved by FDA & is the first cancer drug from Singapore. Vonjo could effectively address an unmet medical need for patients with Myelofibrosis wherein thrombocytopenia is an issue with existing therapy 2) Zotiraciclib Multikinase inhibitor licensed to Tragara Pharmaceuticals/Adastra Pharmaceuticals, Inc.). It is in Phase 2 and is being evaluated for treatment of patients with glioma (Brain tumors)3) CT-1578 (SB-1578) - Phase 1 clinical trials for autoimmune diseases (Rheumatoid Arthritis) SB-1578 is selective a JAK2 kinase inhibitor and it has been licensed to Cell Therapeutics4) 8 patents, 13 journal publications and contributed a book chapter to RSC Show less

-Designing alternate methods of synthesis of existing products -Process optimization and development related work.-Tech. Transfer of new products to pilot plant-Process Validation and creation of technical documentation for PPQ-Audit Support FDA/HSA-Managed a team of 5 chemists and engineers