William Comrie work email
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William Comrie personal email
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As a seasoned leader in immunology and cancer research, I am deeply committed to advancing the field of cancer immunotherapy through innovative research and strategic leadership. I have been responsible for overseeing the design and execution of advanced drug development strategies, particularly focusing on T cell-based therapies such as CAR-T, Armored-TIL, and Armored-TCR-T. This involves managing pre-clinical data, leading cross-functional teams, and directly contributing to bench research, ensuring our projects are rooted in scientific excellence and innovation.My academic foundation, with a Ph.D. in Immunology from the University of Pennsylvania, has provided me with a strong expertise in basic immunology research which has been applied to cancer drug development. Over the years, I have gained extensive experience in various aspects of immunology and T cell biology. This includes leveraging my knowledge of viral and non-viral genetic modifications, developing adoptive cell therapies, and optimizing cell therapy manufacturing processes. I am proficient in utilizing advanced bioanalytical techniques such as multi-color flow cytometry, qRT-PCR, and sophisticated microscopy techniques to analyze and interpret complex data, ensuring the reliability and robustness of our research findings.In addition to my technical skills, I bring strong leadership and strategic vision to my role. I excel in guiding and mentoring scientific teams, fostering a collaborative environment, and driving projects toward successful outcomes. My ability to effectively communicate complex scientific concepts to diverse audiences, including stakeholders, collaborators, and research partners, has been a key asset in my career. I am adept at developing and executing strategies that align with organizational goals, navigating the complexities of drug development and regulatory landscapes with foresight and precision.My career includes numerous publications in top scientific journals, successful patent submissions, and impactful presentations at international conferences. I am passionate about pushing the boundaries of immunotherapy and advancing scientific understanding to make significant contributions to human health. I am always eager to connect with fellow professionals, researchers, and industry leaders to explore collaborative opportunities, discuss the latest advancements in immunotherapy, and share insights on the future of cancer research. Let’s connect and work together to drive forward the next wave of innovation in cancer treatment.
Neomics Pharmaceuticals
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Director Of Discovery Research And Process DevelopmentNeomics Pharmaceuticals Apr 2024 - PresentRockville, Maryland, United StatesAs a key member of the Senior Leadership Team, I help steer our strategic direction, focusing on our clinical pipeline priorities and HR initiatives. My role is all about architecting and executing drug development strategies, from picking the right candidates to proving their clinical potential, all while ensuring we're on track with patent and regulatory compliance.Furthermore, I orchestrate pre-clinical data management to make our IND preparation and filing process seamless. I Oversee project timelines and budgets, while mitigating risks and fostering accountability across our cross-functional teams. Communicating pre-clinical development progress to senior leadership is crucial. I focus on effectively highlighting milestones, risks, and opportunities, and I work closely with functional leads to advance our CMC development and commercialization efforts. Cultivating external partnerships to accelerate our company objectives is also a significant part of what I do.In addition to strategy and leadership, I contribute directly to bench research, ensuring projects advance and meet deadlines.
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Head Of Discovery Research And Pre-Clinical DevelopmentNeomics Pharmaceuticals Oct 2021 - Apr 2024Rockville, Maryland, United StatesIn this role, I strategized and executed research initiatives that aligned with our company's objectives, drawing on my expertise in T cell biology. I focused on developing novel engineered T Cell Therapies (CAR-T, TCR-T, Armored TIL) and implementing robust production methodology and release assays that adhere to FDA regulations for genetically modified ACT.I built and led a high-performing research team dedicated to innovative cell therapies utilizing viral and non-viral genome editing technologies for adoptive cell therapy applications. To ensure operational excellence, I implemented SOPs, BPRs and focused on team development.Scaling CAR-T processes from bench to clinic was a significant milestone, and I played a crucial role in ensuring successful technology development and protocol transfer to our manufacturing site. I also oversaw CRO collaborations and in vivo studies to evaluate the functionality of genetically modified T-cells.While I maintained a hands-on approach to research to drive project advancement, I also successfully transitioned into a leadership role, both in research and development, but also assumed full responsibility for clinical-scale process development. This experience reinforced my ability to lead and deliver results in high-stakes environments.
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Principal ScientistNeomics Pharmaceuticals Sep 2021 - Apr 2024Rockville, Maryland, United StatesAt Neomics Pharmaceuticals, I led the development of cutting-edge CAR-T and TCR-T therapies targeting BCMA and shared tumor antigens. In addition, my work focused on pioneering cell intrinsic checkpoint blockade for TIL therapy.I designed novel CAR constructs and optimized signaling domains for cell-intrinsic checkpoint blockade and executed small-scale process development for CAR-T, TCR-T and TIL therapies. Designing cell-intrinsic strategies to overcome T cell exhaustion was a key part of my role, and I engineered recombinant proteins to optimize T cell function and persistence.Collaboration was crucial to our success. I worked closely with CROs and CMOs to advance projects and developed and validated critical assays for research and CMC transfer. Mentoring and developing team members was another rewarding aspect of my position, as it helped us achieve our strategic objectives and push the boundaries of what's possible in cell therapy.
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Senior Research Scientist INeomics Pharmaceuticals Nov 2019 - Sep 2021Gaithersburg, MdUsed in depth knowledge of human and mouse T lymphocyte biology to design and implement strategies related to the development of adoptive cell therapies; including shared tumor-associated antigens, production of TIL-based therapies, and CAR-T cell design and manufacturing.
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Postdoctoral Research FellowNational Institute Of Allergy And Infectious Diseases (Niaid), Lenardo Lab Nov 2014 - Nov 2019Bethesda, MdAt the NIH's Lenardo Laboratory, I delved into the molecular origins of novel primary immunodeficiency diseases using advanced genomic analysis. My research focused on understanding disease pathogenesis through cutting-edge cellular and molecular techniques with primary human T cells.These findings were translated into actionable therapeutic strategies, aiming to improve patient outcomes. Additionally, I shared my research through peer-reviewed publications and scientific presentations, contributing to the broader scientific community.Securing competitive research funding was also a key part of my role, helping to support and sustain our ongoing research initiatives.
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Prat FellowNational Institute Of General Medical Sciences (Nigms) Sep 2016 - Sep 2019Bethesda, MarylandPRAT research fellow -
Ph.D. StudentUniversity Of Pennsylvania School Of Medicine, Burkhardt Lab Sep 2009 - Nov 2014PhiladelphiaWorking in the laboratory of Dr. Janis Burkhardt, I developed and executed a project that defined the role and regulation of mechanical force applied to cell adhesion molecules during T cell activation and priming by dendritic cells.
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Lab TechUniversity Of Rochester Medical Center Jun 2008 - Jun 2009Working in the Laboratory of Dr. Minsoo Kim I helped describe the dual/opposing roles of the small-GTPase RhoH in the cellular signaling in human T cells downstream of TCR and Chemokine engagement.
William Comrie Skills
William Comrie Education Details
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Immunology -
Microbiology And Immunology
Frequently Asked Questions about William Comrie
What company does William Comrie work for?
William Comrie works for Neomics Pharmaceuticals
What is William Comrie's role at the current company?
William Comrie's current role is Director of Discovery Research @ Neomics Pharmaceuticals | Leading T Cell Therapy Innovation (CAR-T, TCR-T, TIL) for Cancer Immunotherapy.
What is William Comrie's email address?
William Comrie's email address is dr****@****ail.com
What schools did William Comrie attend?
William Comrie attended University Of Pennsylvania, University Of Rochester.
What skills is William Comrie known for?
William Comrie has skills like Cell Culture, Western Blotting, Molecular Biology, Elisa, Biochemistry, Microbiology, Microscopy, Tissue Culture, Protein Purification, Flow Cytometry, Lifesciences, Cell Biology.
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William Soares
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William Comrie
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