William Gao Email & Phone Number

Foster City, Ca, Us

• Characterized and identified unknown impurities in raw material and drug substance using techniques such as LC-MS-MS, GC-MS, FT-IR and NMR.• Developed size exclusion chromatography method with RI detector to analyze polymeric impurities on raw material and drug substance.• Designed and executed analytical equivalency studies to address OOT/OOS investigations at CMOs and CROs.• Authored protocols and reports for analytical method validations and transfers at CMOs and CROs for GMP testing.

• Developed GC-TOF methods with a soft ionization source to analyze the cathinone compounds including chiral derivatization of the starting materials.• Explored GC-QTOF methods to identify the derivatized cardiotonic steroids and their activity in autoimmune arthritis.

Us

• Developed stability indicating HPLC methods for API and drug products. Applied the methods to open dish stability, excipient and packaging compatibility, and product shelf life studies. • Conducted LC-MS/MS analytical tests for pH stability, enzymatic stability, CACO-2 permeability assay, uptake assay and in vivo PK studies.

Palo Alto, California, Us

• Developed photo and acid cleavage methods on a FIA-CLND-MS system and applied for high-throughput library screen in accordance with QC protocol.• Integrated and developed a LC-CLND-MS system for quality control of synthetic libraries.