William Oldham Email & Phone Number

San Carlos, California, Us

o Built and lead a matrixed cross functional team to deliver production ready flow cell from bespoke prototypeo Developed and implemented vertically integrated supply chain for consumables.o Managed global suppliers, CRO’s and CMO’so Lead the team to define reagent kit requirements, configuration and manufacturing strategyo Active technical leader in surface chemistry, microarray, flow cell design, adhesive, Injection molding, kit formulation/storage, material selection and compatibilityo Developed QC methods and strategy

South San Francisco, California, Us

South San Francisco, California, Us

o Evolved the operations team to meet scale, margins, and quality goals.o Process development core team leado Implemented scalable document control, change control, and versioning for all manufacturing lines and documentationo Head of siteo Drove ERP integration and launch for manufacturingo Streamlined supply chain for rapid growth and global markets.

South San Francisco, California, Us

o Worked with the R&D and Marketing teams to develop and implement reagent kits, consumables and Instruments as well as launched both platforms and the kits. o Selected and designed headquarters for Mission Bio, negotiated and delivered favorable lease terms to Mission Bio. o Created top-notch quality department and hired, managed, coached, and trained 7 people while optimizing productivity.o Managed all the ongoing programs feeding into manufacturing, global logistics, EH&S, and IT development o Selected, developed, and managed vendor consultants to provide commercial reagents, consumables, instrument, and kits boxes domestically and internationally.o Implemented scalable document control, change control and versioning for all manufacturing lines and documentation.

South San Francisco, California, Us

South San Francisco, California, Us

South San Francisco, California, Us

Twist Bioscience is a synthetic biology company based in South San Francisco, California.Equipment/ Techniques: Sample Amplification: PCR & RCA, HPLC: Reverse Phase and Ion Exchange, Liquid Handling: Single and Multi-Channel Pipetting Robotics, Oligonucleotide Synthesis, High Throughput Manufacturing Program Design, Packaging and Shipping Support, and Workflow and Lab Design> Worked with the Research & Development team to develop novel synthetic biology techniques and processes to deliver high quality product on time and at scale.Career History - continued> Developed new programs and optimized workflows along with managing manufacturing and operations for oligo pool programs including un-amplified, amplified, and modified pools.> Created thorough, accurate and detailed documentation of all work produced in batch records, work instructions and SOP's.> Supported cost improvement initiatives by reducing all types of failures thus, improving the capacity through process improvement and automation. > Operated and designed workflows for automated lab equipment for molecular/synthetic biology workflows as well as tracked metrics for both physical and functional quality of products for process improvements. > Developed and implemented an EH&S program for manufacturing and managing all the ongoing programs as well as built a hazardous waste control and disposal program for a new manufacturing site.

South San Francisco, California, Us

Equipment/ Techniques: CPS Particle Centrifuge, Fluorescence based Microscopy Guava Flow Cytometer, Eppendorf, and Thermo Centrifuge, Cascada Biowater system, KrosFlow TFF, Labconco Lyophilizer, multiple High Shear Mixing Systems, Next Gen Sequencing, EMPCR, Isothermal Amplification, and Bio Conjugation> Worked as Program Lead of ISP manufacturing for ION PGM platform, ION PGM IVD platform and two NPI’s as well as the leader of PCP pilot program in the business unit.> Served as key team member for integration into global manufacturing and supply chain as well as a part of a two-person team responsible for bringing manufacturing at site from RUO to ISO13485/9001.> Directed the construction of controlled environment GMP lab utilizing Kanban, Shingo and 5S principals.> Communicated and collaborated across functional areas such as upstream process development, analytical development, manufacturing, R&D, project management and regulatory.

Worked as Program Lead of ISP manufacturing for ION PGM NGS platform as well as an R&D team member, contributing to innovation and trouble shooting.Maintained and developed batch records, SOP’s and all manufacturing documentation in compliance with all GMPs.Traveled internationally to work with supplier sites to verify supply quality as well as mentored new employees as well as directed their work responsibilities. Collaborated closely with drug substance and drug product process development colleagues along with managing activities at contract manufacturing and testing sites.

Owner of both synthesis and contract manufacturing for three programs, from discovery candidate through solid state research and up to phase 1 clinical trials. Responsible for evaluating and managing new contract manufacturing organizations for synthesis and process research. Traveled internationally to negotiate manufacturing contracts and to ensure quality products were produced. Decision maker for departmental kilo-suite equipment purchases. Maintained, operated and trained staff on a thermo HPLC-MS. Hired and supervised a successful technician. •Trained on Finnegan (HPLC-MS), Thermo (MS), Agilent (HPLC), waters (HPLC), crystal 16 instruments. Interpreted XRD, TGA, DSC, pH Meter, Raman, FT-IR and NMR.•Experienced with MS Office, Net Meeting, Oracle, Chemstaion, Sci-finder and Xcaliber

Alameda, California, Us

Process development team member responsible for the delivery of 100g to 5 Kg of advanced intermediates or drug substance/product using in-house GLP-Kilo equipment suite. Responsible for finding and scaling of the most stable/producible polymorph. Traveled extensively to develop manufacturing partnerships with foreign production facilities. Co-designed and managed a new chemical inventory for the synthesis department. Received an “EXELence” award for exceptional performance.•Used Agilent (HPLC), waters (HPLC-MS), Varian (NMR), crystal 16 instruments. Interpreted XRD, TGA, DSC, Raman, FT-IR and NMR.•Experienced with MS Office, MS Project, Net Meeting, Oracle, Chemstaion, Sci-finder and DOE ed with MS Office, MS Project, Net Meeting, Oracle, Chemstaion, Sci-finder and DOE

Equipped and managed a lab for eight chemists and served on the safety committee. Hired and managed lab technicians. Owner of ten compound libraries of 500 plus compounds each. Additionally responsible for all related intermediates and high value compounds. Purchased & maintained $1M worth of chemistry lab equipment. Co-lead engineer on startup of a new micro-reactor, which was used to produce previously un-reachable compounds. Received employee recognition award for exceptional performance. Hired and managed lab technicians.•Used and repaired Agilent (HPLC), Therno (HPLC-MS), Varian (NMR), Gilson (HPLC)