William Hesse Email & Phone Number

Arlington, Massachusetts, United States

Boston, Massachusetts, US

• Oversaw development of Electronic Notebook application which is intended to reduce the number of systems that are utilized by lab personnel by half.
• Lead development through live production sample processing of new, custom lab informatics system to replace paper recording of lab processing, which lead to a twenty-four hour reduction in turn-around-time
• Collaborated with lab staff to gather requirements, carry out user acceptance testing, and plan release timing
• Developed quarterly plans and structured releases to deliver key features when needed by the business
• Coordinated responses to system issues with support, development, and lab teams to identify root cause and implement solutions

Boston, Massachusetts, US

• Lead design and implementation of a $1M workcell for preparing samples for NGS analysis
• Developed strategy for extending automation into areas not currently covered by laboratory automation
• Developed plan for unifying user interface experience, and extending GxP compliance
• Lead Root Cause Analysis into issues arising from hardware and automated protocols
• Drafted documentation for regulated design change controls
• Lead design, prototyping of imaging systems for analyzing FFPE tissue

Boston, MA, US

- Lead cross-foundry initiatives to streamline sample handling- Developed python applications that were deployed via Docker- Collaborated with the software engineering team to develop new software tools

Boston, MA, US

- Lead transformation sub-group- Developed production software for generating sample handling workflows- Developed high-through protocols for arraying DNA on automated workcells- Enhanced DNA analysis pipelines for NGS data

• Developed a database for tracking PDMS chip production and a webapp to access and display data from this database
• Designed 3D solid models for manufacture with CNC, 3D printing, and injection molding
• Developed processes for large-scale manufacture of PDMS microfluidic chips
• Analyzed costs associated with manufacturing processes
• Interfaced with clients and suppliers to facilitate product design

Cambridge, MA, US

• Created a library (~1000) of yeast strains with fluorescent reporters to determine the proteotoxic effects of genes associated with neurodegenerative diseases
• Utilized automated, high-throughput microscopy to image the library (~900,000 individual cells)
• Computationally analyzed imaging data sets to assess changes in protein abundance and localization
• Used microfluidics to induce cellular phenotypes that were followed with time-lapse microscopyAwards that funded this work: NSF GRF, Poitras Pre-doctoral Fellowship, MIT GSC Travel Grant

Cambridge, MA, US

• Consulted with individual clients and groups to improve the clarity of scientific communications
• Developed and delivered workshops on creation of posters, papers, and presentations

Cambridge, MA, US

• Conducted single molecule experiments and molecular dynamics simulations on six chimeric kinesin constructs, and developed a model of how three components from two kinesin families work together to generate force
• Developed antibody for blocking the force generation capabilities of kinesin
• Designed and implemented laser based optical systemsAwards that funded this work: NSF GRF, DOD NDSEG

Cambridge, Massachusetts, US

Philadelphia, Pennsylvania, US

• Devised methods for imaging bacterial flagella using electron and fluorescence microscopy
• Developed methods for mineralization of bacterial flagella for nano-materials
• Engineered magnetic micro-swimmer based moved with the use of bacterial flagella
• Designed and implemented a microscope stage insert for creating three-dimensional rotating magnetic fields at the microscope’s focal point.Awards that funded this work: August H. Hess Scholarship

New York, NY, US

• Revised models of energy usage by typical train consists
• Reviewed technical and contractual documents for four transit agencies
• Designed the layout for a new interior for passenger rail cars

Allentown, PA, US

• Enhanced the company’s part management system by the addition of specifications for hundreds of uncharacterized parts
• Researched and tested RFID technologies to track telephone poles and transformers

Doctor Of Philosophy (Phd), Biological Engineering

Certificate, Biophysics

Master Of Science (Sm), Mechanical Engineering

Bachelor Of Science (Bs), Mechanical Engineering