William Nguyen Email & Phone Number

Parkville, Victoria, Australia

Medicinal Chemist in the ACRF Chemical Biology DivisionAreas of research:- Peptidomimetics and small molecules targeting malaria- PROTAC design and synthesis- Small molecules targeting Schistosomiasis- Agents which reverse HIV-1 latencyChemistry is an essential component of successful biomedical research. With a strong focus on medicinal chemistry and chemical biology, our lab strives to integrate multi-disciplinary approaches based on cohesive teams of researchers. To achieve this goal, we have strong collaborations with a number of institute divisions and all our projects are run as multidisciplinary collegial teams.

Parkville, Victoria, Australia

Medicinal Chemist in the ACRF Chemical Biology Division

Melbourne, Australia

Melbourne Area, Australia

Department Of Molecular Therapeutics. The Scripps Research Institute:

Postdoctoral Researcher• Multistep syntheses of over 300 final compounds based on rational drug design• Worked collaboratively with biologists and pharmacologists (DMPK) to build comprehensive drug profiles and optimize physicochemical properties.• Successful outcomes of my work have led to a patent on a library of CNS targeted compounds for the treatment of nicotine addiction (Orexin 1 antagonists).• Instrumental analysis and purification using analytical and preparative HPLC, Chiral HPLC, NMR, MS, LCMS, IR and MP• In charge of managing/maintaining LCMS machines (both Agilent and Thermo/Dionex) + Waters and Shimadzu HPLC• Method development of HPLC, chiral HPLC and LCMS runsScripps Co-Social Chair• Organizing social events for the Scripps Research Fellows

Melbourne Area, Australia

Medicinal Chemistry Drug Discovery project aimed at blocking ion channels (Kv1.3) for the treatment of autoimmune diseasesSynthetic chemistry work includes:• Multistep synthesis of a library of compounds based on diphenoxylate• Synthesis of analogues to construct the SAR profile of a lead molecule• Improving the syntheses of established chemotypes and development of new ones• Hybrid molecule design and synthesis combining other potent inhibitors with our own • Improving physicochemical properties for topical and oral delivery in the design of compounds• Molecular Modelling work on potassium channel homology models• Instrumental analysis and purification using analytical and preparative HPLC, NMR, MS, LCMS, IR and MP

Phd, Medicinal Chemistry

Bachelor, Medicinal Chemistry (With Honours)