Wei-Lun Hsu Alterovitz Email & Phone Number

Washington, DC, US

Bergisch Gladbach, North Rhine-Westphalia, DE

- Develop and implement bioinformatics analysis strategy for tumor target antigen discovery in CAR and TCR pipelines.- Drive development activities, identify and address computational and statistical challenges in the analysis pipelines.- Develop best-practice bioinformatic analysis protocols for data storage and analysis result reproducibility.- Develop.

Palo Alto, California, US

ScreeningPrecision oncology, tumor profiling, liquid biopsy, bioinformatics, NGS.- Designed and defended analytical experiments with clinical samples.- Developed statistical methods and procedures, described and validated Guardant’stechnologies.- Wrote experimental protocols and reported in collaboration with assay developmentscientists.- Supported the.

Silver Spring, MD, US

Center for Biologics Evaluation and Research, Office of Tissues and Advanced Therapies, Division of Cellular and Gene Therapies- Developed bioinformatics data standards and guidance for scientific and regulatory reviews of OTAT. - Performed bioinformatics data analyses using internally developed tools as well as open-source software and prediction.

Silver Spring, MD, US

[1 talk, 6 publications, 5 posters]Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology- Established antibiotic resistance pipelines by customizing and assembling various tools like Hexagon, Blast, genome assembler (SPAdes), Resistance Gene Identifier (RGI) and Comprehensive Antibiotic Resistance Database (CARD) to examine.

Silver Spring, MD, US

Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology - Studied liver toxicity effects of Vem (BRAF inhibitor) and Ipi (CTLA4 Ab) as a combination therapy for melanoma. Applied NGS technology to explore underlying mechanisms and novel biomarkers to stratify patients for better/precise treatment and outcomes. - Ran.

Gaithersburg, Maryland, US

Basel, Baselstadt, CH

[1 talk]- Identified novel isoform targets in various cancer indications by mining public RNAseq datasets (TCGA, CCLE, GTEX and BLUEPRINT). Developing informative indexes and function-related annotations to improve ranking algorithm (for antibody drug conjugate and immune therapeutics). - Scientific lead of project team that was developing an enterprise.

Bloomington, Indiana, US

[8 publications, 4 talks, 4 posters]- Established molecular recognition feature (MoRF) databases and investigated the underlying regulatory mechanisms including alternative splicing events and posttranslational modifications.- Explored the binding diversity of intrinsically disordered proteins and integrated various bioinformatics algorithms.

[1 publication]- Carried out molecular dynamics simulations and Molecular Mechanic/Poisson-Boltzmann Surface Area (MM-PBSA) analysis to investigate the binding affinity of protein-protein interactions. Participated in protein interaction interface re-design.

- Developed a robotic algorithm to build a representative structural domain database based on sequence comparisons and domain assignment methods.

Hsinchu, Taiwan, TW

[1 publication]- Developed/maintained/IT-supported online bioinformatics databases, applications and webservers in the molecular bioinformatics center and helped manage/propose research grants.

Hsinchu, Taiwan, TW

- Constructed statistical/mathematical models to predict protein relative solvent accessibility from amino acid sequence (by machine learning approaches e.g. support vector machine).

Adaptive Intelligent Internet Agents Lab, Institute of Information Science- Applied the web wrapper agent toolbox to bioinformatics research (application support).

- Annotated a knowledge information sharing system based on object-oriented software engineering.

- Case studied on drug abuse incidents and related healthcare/clinical data.

- Interviewed, reported and edited information technology news as a journalist.

- Co-led the team and did epidemiological studies and health behavior survey regarding to the prevalence, accessibility, satisfaction and health education of cervical smear tests in Xikou County.

Doctor Of Philosophy (Ph.D.), Biochemistry And Molecular Biology. Minor In Life Science.

Master Of Science (M.S.), Bioinformatics And Systems Biology

Bachelor Of Science (B.S.), Public Health

Bachelor Of Science (B.S.), Information Management

Education record