Benjamin Wolf Email & Phone Number

Foster City, CA, US

• ‘Core Biologist’ for a small molecule tumor immune evasion target focused on selectivelyinducing tumor cell Type I IFN. Coordinated all in vitro and in vivo biology work for the project(MOA, potency, PK/PD/efficacy.
• Project Lead for a second tumor immune evasion target focused on sensitizing tumor cells toextrinsic apoptosis ligands like TRAIL and TNFα. Responsible for overseeing work betweendepartments (~20 internal project team.
• Management of 2 direct reports, with a focus on identifying and executing on novel tumorimmune evasion drug targets (such as inducing tumor cells to express Type I IFNs)
• Conceived of and performed initial generation of CD8 T/NK cell: Tumor cell co-culture assays,which were utilized in the above two projects and modified by other project teams for theirprograms. Some of this co-culture.
• Member of the Tango Therapeutics collaboration team, helping to drive collaboration strategyaround identifying novel tumor cell immune evasion targets through Crispr screens
• Assisted with diligence on two external assets, including presentations to the CSO and CMO

Foster City, CA, US

Boston, MA, US

Boston, MA, US

I lead the Translational Immunology and Immunopharmacology team for Adaptive Cellular Immunopharmacology. My team, consisting of 4 direct reports and myself, is focused on interrogating how Compass' drugs modulate in vitro T cell biology to help inform decisions on which molecules become drug candidates. We also perform IND enabling studies and write non.

Lexington, Massachusetts, US

In the immune education/cell therapy division I work on undisclosed immuno-oncology based cellular therapies (e.g., CAR-T / rTCR-T) against cancer. In my position, I routinely isolate primary human immune cells, expand them in vitro, manipulate them with lentivirus transduction or mRNA electroporation if needed, and then test their ability to be activated.

US

My Postdoctoral research fellowship is focused on studying an enigmatic subset of T cells called NKT cells. We identified microbe-derived lipids that activate NKT cells in vitro and are studying these cell populations in vivo (including human PBMCs and mouse organs). This work required us to develop methods of extracting lipids from microbes, purifying.

Boston, MA, US

I have a joint appointment at Harvard Medical School as a research fellow. Both appointments are done in the lab of Michael Brenner, where I work on NKT cells.

NY, US

My dissertation research was focused on MHC class I antigen presentation of proteins derived from Listeria monoctyogenes. Importantly, our work highlighted the fact that mammalian cells can tell when a protein comes from an exogenous source (such as from an intracellular pathogen) instead of host cell ribosomes. This work was published in two manuscripts.

Doctor Of Philosophy (Phd), Microbiology And Immunology

Bs, Biology, General