Quality control and biosafety in the field of gene and cell therapies, genome editing, virology and bioproduction. Management of R&D and CQ activities dedicated to viral vectors and viral products and processes.Expert knowledge of rLV, rAAV, rAdV and related characterization techniques. Expert knowledge of gene therapy regulatory guidelines (EP, USP). Skilled in scientific projects steering, quality control activities, development and validation of analytical assays… Show more Quality control and biosafety in the field of gene and cell therapies, genome editing, virology and bioproduction. Management of R&D and CQ activities dedicated to viral vectors and viral products and processes.Expert knowledge of rLV, rAAV, rAdV and related characterization techniques. Expert knowledge of gene therapy regulatory guidelines (EP, USP). Skilled in scientific projects steering, quality control activities, development and validation of analytical assays according to EP, USP and ICH and in compliance with GLP/GMP guidelines, development of innovative technologies dedicated to virologics characterization through bioengineering of viral vectors, bioproduction of viral vectors and viruses. Team management, reporting to scientific committees, regulatory consulting, assistance to business units.Participation to international collaborative studies for the standardization of analytical procedures. Show less

Higher Studies Practical School (Ecole Pratique des Hautes Etudes, EPHE) - Paris-Sorbonne University (France)- Human genetics courses - Genome engineering, gene and cell therapies (2nd year of master degree)

GENOME ENGINEERING, GENE THERAPY, VECTOROLOGY & BIOPRODUCTION- Scientific projects steering- Meganuclease-driven genome engineering (therapeutic and bioproduction purposes)- Development of innovative gene expression systems for the characterisation of engineered nucleases - Duchenne Muscular Dystrophy (DMD) biology and study of other neuro-muscular disorders- Development of optimized production processes for lentiviral vectors biomanufacturing- Development of de novo… Show more GENOME ENGINEERING, GENE THERAPY, VECTOROLOGY & BIOPRODUCTION- Scientific projects steering- Meganuclease-driven genome engineering (therapeutic and bioproduction purposes)- Development of innovative gene expression systems for the characterisation of engineered nucleases - Duchenne Muscular Dystrophy (DMD) biology and study of other neuro-muscular disorders- Development of optimized production processes for lentiviral vectors biomanufacturing- Development of de novo purification processes for new lentiviral vectors pseudotypes biomanufacturing- Development of a new lentiviral vector pseudotype for the generation of Sf9 producer cell lines for the large-scale biomanufacturing of AAV-based vectors (baculovirus system)- Management of a lentiviral vector production unit (BSL2)- Development of analytical assays- Logistical and operational management- Staff management and training activities- Budget and documentation management- Reporting to scientific committees- Communication and teaching activities- Scientific intelligence Show less

Evaluation and optimisation of gene correction stratégiesThesis director: Dr Olivier Danos

University of Versailles Saint-Quentin-en-Yvelines (France) - Genetics and cell biology department- Courses : molecular and cell biology, formal and fundamental genetics (BSc level)

Dr Muriel Audit laboratory (henceforth Genosafe)- Development and validation of a method for the quantification of integrated lentiviral vector genomes and measurement of transgene expression levels using RT-qPCR assays