Xiang L. work email
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Xiang L. personal email
Bioinformatician at PSC/ JnJ/ GentiBio/ Sana/ Guardant HealthAWS Certified Cloud Practitioner, Author of HiChub, PhD with Park Prize ▪A computational physicist by training with over 9 years experience in computational genomics.▪My research interest focus on Cell Characterization (Variants Calling, CRISPR-cas screening and Transcriptional Regulation)▪I built a toolbox basing on chromatin interaction data (Hi-C) and integrate a diverse epigenomics data including Amplicon-seq, RNA-seq, ChIP-seq, DNase-seq/ATAC-seq, Bisulfite-seq, HiC, and many public dataset (GEO, 4DN and etc) to uncover the gene regulation mechanism in T cell immunity.▪Led, built and managed bioinformatics pipelines for GentiBio and Peng Lab.
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Bioinformatics Scientist IiGentibioCambridge, Ma, Us
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Senior BioinformaticianPittsburgh Supercomputing Center Aug 2024 - PresentPittsburgh, Pa, UsSupport HuBMAP under Common Fund Data Ecosystem (CFDE) https://commonfund.nih.gov/dataecosystem -
Senior Bioinformatician (Psc)Carnegie Mellon University Aug 2024 - PresentPittsburgh, Pa, Us -
Member Of Youth Editorial BoardPhenomics Journal 2024 - Present -
Project ManagerLuffing Future Llc Jan 2020 - PresentWashington, District Of Columbia, UsClients:JnJ (2024)LifeMine Therapeutics (2024)Verily Life Sciences (2023) Mokobio Biotechnology R&D Center (2018)With the art of open source AI tools, Algorithm and public Data, Explore the comercialization on data mining.** scRNAseq & scATACseq integration**Auto-Extraction financial data from public company's quaterly report(FORM 10-Q). (In-progress, 2023)**Evaluation system for given carfax report (Recommend Price & Condition, 2020, achieved 40% gross profits for 5 cars)**Automation system to pay for parking tickets basing on computer vision (2019) -
Scientist Iii, RweJohnson & Johnson 2024 - 2024New Brunswick, Nj, UsR&D in Real World Evidence, Patient profiling from medical history (EHR, EMR)Dev a toolset from scratch for patient profile, alignment, visualization and analysis(built a fully connected network for ~million patients). -
Senior Bioinformatics ScientistGentibio 2023 - 2024Cambridge, Massachusetts, Us• Build computational components for GENTI122 IND package (Safety assessment for Gene Editing).• • Build SNIP-aware (gnomAD v4.0) insilico Off-target analysis for Cas9 editing• • On/Off-Target analysis protocol: in-Silico ⇒ GUIDES eq ⇒ rhAMPS eq.• • Build a full-stack web app (aws) for automation. Similar to CRISPResso2 Web• Build Cellular Profiling Platform:• • scRNAseq & scATACseq integration analysis, Kidney biopsies from Mouse IgA Model• • Deploy GentiBio internal chatGPT & Automation pipeline through AWS• • Deploy AWS VC-backed startup package and build Bioinformatics Infrastructure.• • Write analysis tools (python & R) and pipeline (bash, Nextflow Docker)• • Adopt bulk/scRNAseq analysis pipeline and downsteam analysis• • CAR design, Implement Alphafold2 & AlphaMissense for IBD, FliC CAR.
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Bioinformatics Scientist IiGentibio 2022 - 2023Cambridge, Massachusetts, UsBioinformatics Support for Early Discovery TeamBioinformatics-Lead in building Cellular Profiling Platform:** Deploy gentibio internal chatGPT** Deploy AWS VC-backed startup package and build Bioinformatics Infrastructure.** Write analysis tools (python & R) and pipeline (bash, Nextflow & Docker)** Deployed bulk/scRNAseq/Bisulfite analysis pipeline and downsteam analysis such as: Transcript isoform expression and in-silico cell2cell interaction prediction.
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Scientist, Computational BiologySana Biotechnology, Inc. 2021 - 2022Seattle, Washington, UsCell Safety Assessment/computational pipeline development -
Bioinformatics ScientistGuardant Health 2021 - 2021Palo Alto, California, UsBioinformatics (Algorithm Development Team).1. Study tumor fraction prediction by cell-free DNA fragment size distribution. (*Built a Deep Learning module for production pipeline(BIP4.0). *Lead a patent filing.)2.Study of a rare contamination found in sequence. *Support variants calling by wrote a python based filtering module for BIP4.0. -
Research ScientistThe George Washington University 2020 - 2021Washington, D.C., Us* Scientific Computing Support (HPC) -
Graduate Research AssistantThe George Washington University 2017 - 2020Washington, D.C., Us*Design workflow and anlysis pipeline for dealing with the order of tens of billions genomic data.( DNase_seq, Hi-C, ChIP-Seq, RNA-Seq , scRNA-Seq(10X) and etc. )*Using multi-NGO programs embeded in Shell Scripting and Python to build highly efficient pipelines to solve technical and scientific problems.*Linux Server Administration
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Graduate Teaching AssistantThe George Washington University 2016 - 2018Washington, D.C., UsCourses I taught as an instructor. 1. 'Introduction to Astrophysics.'2. 'Modern Physics: 'Wave Optics'3. 'Electronic Circuit'4. 'Models of Atom'5. 'Special Relativity'
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Research AssistantInternational Monetary Fund Jun 2018 - Dec 2018Washington, Dc, UsModeling Study of Currency Exchange Rate by deep learning (RNN) or physical model.*Focus on the key factors of exchange rate and its periodic behavior. -
Research AssistantXiamen University Dec 2014 - Jul 2015Fujian, CnA research project about Spatial Analysis of Sea Surface Carbon Dioxide data.This is an independent research project, I pretty much did everything started from scratch. I proposed a spatial statistical model and based on that model, design a algorithm and finally come up with a MATLAB toolbox to solve general cases automatically. -
Co Team LeadHarvard University May 2014 - Nov 2014Cambridge, Massachusetts, UsPreparing for 2014 Biomod Competition, hosted by WYSS & INSTITUTE, Harvard.It's a bio-physical dynamic model, using magnetic impulse to push forward nano-scale robot towards a targeted direction.Silver Award.
Xiang L. Skills
Xiang L. Education Details
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The George Washington UniversityPhysics -
Huazhong University Of Science And TechnologyApplied Physics
Frequently Asked Questions about Xiang L.
What company does Xiang L. work for?
Xiang L. works for Gentibio
What is Xiang L.'s role at the current company?
Xiang L.'s current role is Bioinformatics Scientist II.
What is Xiang L.'s email address?
Xiang L.'s email address is xi****@****ana.com
What schools did Xiang L. attend?
Xiang L. attended The George Washington University, Huazhong University Of Science And Technology.
What skills is Xiang L. known for?
Xiang L. has skills like Shell Scripting, Mathematical Modeling, Latex, Photography, Python, Matlab, Java, Linux System Administration, Linux Server, Python, Data Analysis, Physics.
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