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Xiao-Pei Guan, Ph.D. Email & Phone Number

Senior Scientist at Miltenyi Biotec, Nucleotide Chemistry, NGS at Miltenyi Biotec
Location: North Andover, Massachusetts, United States 7 work roles 3 schools
1 work email found @miltenyibiotec.com LinkedIn matched
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Current company
Miltenyi Biotec
Role
Senior Scientist at Miltenyi Biotec, Nucleotide Chemistry, NGS
Location
North Andover, Massachusetts, United States

Who is Xiao-Pei Guan, Ph.D.? Overview

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Xiao-Pei Guan, Ph.D. is listed as Senior Scientist at Miltenyi Biotec, Nucleotide Chemistry, NGS at Miltenyi Biotec, based in North Andover, Massachusetts, United States. AeroLeads shows a work email signal at miltenyibiotec.com and a matched LinkedIn profile for Xiao-Pei Guan, Ph.D..

Xiao-Pei Guan, Ph.D. previously worked as Senior Scientist at Miltenyi Biotec and Scientific Expert, Nucleotide Chemistry, Next Generation Sequencing Development at Qiagen. Xiao-Pei Guan, Ph.D. holds Doctor Of Philosophy (Ph.D.), Organic Chemistry from Beijing Institute Of Technology.

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Email format at Miltenyi Biotec

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*@miltenyibiotec.com
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Profile bio

About Xiao-Pei Guan, Ph.D.

Highly Accomplished Senior Chemist with extensive experience in synthetic organic chemistry, medicinal chemistry and analytical chemistry. Highly skilled in trouble-shooting and problem-solving. Specialized in designing and implementing efficient syntheses and purification methods for modified nucleotides, cleavable linkers and fluorescent dye labeling. Innovative research on microencapsulation of pharmaceutical agents for drug delivery system. Exceptional collaboration skills with cross-functional teams in a matrix environment.• Expertise in designing and executing multi-step syntheses of functional organic molecules of therapeutic importance, heterocyclic chemistry, metal catalyzed reactions, photochemical synthesis, asymmetric synthesis and parallel synthesis;• Hands-on experience with photoreactor, ozone generator, microwave reactor and J KEM reactors;• Specialized in synthesis, purification and analytical method development of modified nucleosides and nucleotides, cleavable linkers and fluorescent dye labeling;• SBS sequencing chemistry: trouble-shooting, mechanism and optimization;• Strong knowledge of structure-based drug design and targeted focused libraries for drug discovery;• Highly skilled in application of modern spectroscopic / chromatographic techniques for compound isolation, purification, structural and mechanistic elucidation;• Hands-on experience with NMR (1D & 2D), LC-MS, HPLC (RP, HILIC & chiral), GPC/SEC, Prep-LC (RP & ion exchange), flash chromatography, SPE, polarimeter, FT-IR, UV-Vis;• In-depth knowledge and experience with HPLC and LC-MS method development;• Extensive knowledge in microencapsulation of pharmaceutical agents (small-molecules and proteins) for controlled release;• Large-scale synthesis, purification and process development and improvement;• Extensive CRO experience.

Listed skills include Organic Chemistry, Organic Synthesis, Synthetic Organic Chemistry, Nmr, and 45 others.

Current workplace

Xiao-Pei Guan, Ph.D.'s current company

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Miltenyi Biotec
Miltenyi Biotec
Senior Scientist at Miltenyi Biotec, Nucleotide Chemistry, NGS
Website
miltenyibiotec.com
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7 roles

Xiao-Pei Guan, Ph.D. work experience

A career timeline built from the work history available for this profile.

Senior Scientist

Current
Miltenyi Biotec

Bergisch Gladbach, North Rhine-Westphalia, DE

Nucleotide Chemistry, NGS

Nov 2019 - Present

Scientific Expert, Nucleotide Chemistry, Next Generation Sequencing Development

Qiagen

Venlo, Limburg, NL

  • Developed proprietary nucleotide chemistry used in the development of a NGS IVD-ready workflow based on a novel clonal amplification and SBS methodologies
  • Synthesized novel reversible terminated dNTPs and the corresponding fluorescently labeled dNTPs with novel cleavable linker for NGS
  • Optimized the production of all our nucleotides to enable manufacturing and supply chain for the GeneReader System portfolio. Significantly increased the scale and the yield for both the reaction and purification in.
  • Investigated and synthesized novel cleavable linkers and the function of corresponding labeled dNTPs
  • Real time stability study of reversible terminated dNTPs to determine their shelf life
  • Investigated the mechanism and kinetics of the cleave of reversible terminator. Identified the intermediate and rate-determining step and helped optimizing the cleave chemistry on GeneReader
Jul 2016 - Nov 2019

Senior Scientist

Organix Inc.

US

  • Contract Research in Synthetic Organic and Medicinal Chemistry
  • Custom synthesis of small organix molecules in all structural classes, including but not limited to aromatics, carbohydrates, cannabinoids, heterocycles, peptides and tropanes
  • Synthesis of small targeted and focused libraries of compounds for drug discovery
  • Design, evaluation and optimization of synthetic procedures
  • Synthesis scale-up to multi-gram to multi-hundred gram quantities of potential candidates for preclinical studiesMicrosphere Preparation, Microencapsulation of a Variety of Drugs and Their Release Profiles
  • Microencapsulation of chemotherapeutic agents, opioids for pain management, and antivenom
May 2005 - May 2016

Industrial Postdoctoral Research Associate

Organix Inc.

US

Feb 2001 - Apr 2002

Postdoctoral Research Associate

City College Of New York

New York, US

  • Developed Strategies and Carried Out the Synthesis of Various Polyazaheterocyclic Ring Systems, Including Synthesis and Chemistry of Azetidine, Piperidine and 1,5-Diazacyclooctane Derivatives.
  • Studied ring functionalization of 1,3,5,7-substituted-1,5-diazacyclooctane derivatives
  • Developed an efficient procedure for construction of 3,5-substituted-1,5-diazacyclooctanes
  • Established a new convenient acylative dealkylation of tertiary amines
  • Developed a novel one-pot synthesis of 1-acetylpiperidin-3-one via Pd(OH)2-catalyzed hydrogenolysis
  • Established a highly efficient method for the dealkyl-nitrolysis of 1-alkyl-3-azetidinol
Aug 1996 - Jan 2001

Research Scientist

Beijing Institute Of Technology

北京, Beijing, CN

  • Synthesis and Chemistry of Saturated Polycarbocyclic “Cage” Molecules, including Homocubanes, Bishomocubanes and Trishomocubanes
  • Synthesis and Chemistry of Polyheterocyclic "Cage" Compounds, including Polyaza and Polyoxa Isowurtzitanes
  • Synthetic and Thermal Study on New High Energy Density Materials (HEDM)
  • Routine Maintenance and Operation of NMR Spectrometer
Nov 1993 - Jul 1996
Team & coworkers

Colleagues at Miltenyi Biotec

Other employees you can reach at miltenyibiotec.com. View company contacts →

TJ Thomas J. Cincotta Thomas J. Cincotta Colleague at Miltenyi Biotec Frederick, Maryland, United States, United States View → DA Dr. Alexander M. Dr. Alexander M. Colleague at Miltenyi Biotec Cologne, North Rhine-Westphalia, Germany, Germany View → MB Martin Büscher Martin Büscher Colleague at Miltenyi Biotec Cologne Bonn Region, Germany View → AR Antje Rahm Antje Rahm Colleague at Miltenyi Biotec Bergisch Gladbach, North Rhine-Westphalia, Germany, Germany View → DS Daniela Schäfer Daniela Schäfer Colleague at Miltenyi Biotec Cologne Bonn Region, Germany View → AJ Amanda Jama Amanda Jama Colleague at Miltenyi Biotec San Diego, California, United States, United States View → KK Kyriaki Kotaropoulou Kyriaki Kotaropoulou Colleague at Miltenyi Biotec Cologne, North Rhine-Westphalia, Germany, Germany View → AN Alex Nusstein Alex Nusstein Colleague at Miltenyi Biotec Germantown, Maryland, United States, United States View → UC Ulrike Clemens Ulrike Clemens Colleague at Miltenyi Biotec Radolfzell, Baden-Württemberg, Germany, Germany View → BV Barbara Volaric Barbara Volaric Colleague at Miltenyi Biotec Cologne, North Rhine-Westphalia, Germany, Germany View →
3 education records

Xiao-Pei Guan, Ph.D. education

Doctor Of Philosophy (Ph.D.), Organic Chemistry

Beijing Institute Of Technology

Master Of Science (M.Sc.), Organic Chemistry

Beijing Institute Of Technology

Bachelor Of Science (B.Sc.), Chemistry, Organic Chemistry

Peking University
FAQ

Frequently asked questions about Xiao-Pei Guan, Ph.D.

Quick answers generated from the profile data available on this page.

What company does Xiao-Pei Guan, Ph.D. work for?

Xiao-Pei Guan, Ph.D. works for Miltenyi Biotec.

What is Xiao-Pei Guan, Ph.D.'s role at Miltenyi Biotec?

Xiao-Pei Guan, Ph.D. is listed as Senior Scientist at Miltenyi Biotec, Nucleotide Chemistry, NGS at Miltenyi Biotec.

What is Xiao-Pei Guan, Ph.D.'s email address?

AeroLeads has found 1 work email signal at @miltenyibiotec.com for Xiao-Pei Guan, Ph.D. at Miltenyi Biotec.

Where is Xiao-Pei Guan, Ph.D. based?

Xiao-Pei Guan, Ph.D. is based in North Andover, Massachusetts, United States while working with Miltenyi Biotec.

What companies has Xiao-Pei Guan, Ph.D. worked for?

Xiao-Pei Guan, Ph.D. has worked for Miltenyi Biotec, Qiagen, Organix Inc., City College Of New York, and Beijing Institute Of Technology.

Who are Xiao-Pei Guan, Ph.D.'s colleagues at Miltenyi Biotec?

Xiao-Pei Guan, Ph.D.'s colleagues at Miltenyi Biotec include Thomas J. Cincotta, Dr. Alexander M., Martin Büscher, Antje Rahm, and Daniela Schäfer.

How can I contact Xiao-Pei Guan, Ph.D.?

You can use AeroLeads to view verified contact signals for Xiao-Pei Guan, Ph.D. at Miltenyi Biotec, including work email, phone, and LinkedIn data when available.

What schools did Xiao-Pei Guan, Ph.D. attend?

Xiao-Pei Guan, Ph.D. holds Doctor Of Philosophy (Ph.D.), Organic Chemistry from Beijing Institute Of Technology.

What skills is Xiao-Pei Guan, Ph.D. known for?

Xiao-Pei Guan, Ph.D. is listed with skills including Organic Chemistry, Organic Synthesis, Synthetic Organic Chemistry, Nmr, Chromatography, Hplc, Drug Discovery, and Lc Ms.

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