Xin G. Email & Phone Number

Boston, Ma, Us

New Brunswick, New Jersey, Us

-Developed nanoparticle formulations, including liposomes and nanostructured lipid carriers, equipped with peptide targeting moieties for treating pancreatic cancer.-Performed investigative studies to assess the impact of solvents, surfactants, and formulation conditions on the properties of nanoparticles.-Conducted comprehensive characterization of nanoparticles using Dynamic Light Scattering systems to measure particle size and zeta potential.- Designed and performed bioconjugation of lipids and peptides using click chemistry techniques to enhance the delivery and efficacy of therapeutic agents.-Executed rigorous analytical procedures, including High-Performance Liquid Chromatography (HPLC), mass spectrometry, and Nuclear Magnetic Resonance (NMR), to confirm the structure and stability of conjugates.-Performed real-time quantitative PCR (RT-qPCR) tests to measure mRNA expression across various cancer cell lines and validated protein expression through immunocytochemistry, Western blotting, and flow cytometry; optimized methods for immunoassays.-Maintained cell cultures following SOPs in a sterile environment for conducting cell-based assays and in vitro experiments, including receptor binding, fluorescent imaging, and MTT assays for cell viability and proliferation.-Collaborated in the design of animal model studies. Monitored and reviewed experimental progress and data collection to contribute to the refinement of study parameters and outcomes.-Reviewed and analyzed study designs, technical reports, and standard operating procedures to ensure compliance.

New Brunswick, New Jersey, Us

New Brunswick, New Jersey, Us

Shung Wan, Hong Kong, Hk

- Actively participated in the development of generic controlled release nanoparticles that encapsulated small molecular APIs for the treatment of metastatic breast cancer, lung cancer as well as fungal infections. - Competently performed analysis for in-house samples with GC and HPLC (coupled with PDA, UV, RI, and fluorescence detectors); troubleshooting problems associated with advanced analytical instruments and data interpretation.- Took the initiative in the implementation of dissolution testing for in-house samples with Dissolution Apparatus USP 7 to meet biowaiver and bioequivalence related FDA requirements; analyzed dissolution testing results with the project team and provided suggestions for further study optimization. - Coordinated primarily with external contract research and manufacture organizations; presented results to groups, teams, and company partner; delivered ad hoc activities/changes as required to support senior managements’ decision making.- Supported the preparation of ANDA and 505(b)(2) submission documents and worked with cross-functional teams of Regulatory Affairs, Analytical Development, Quality Assurance; established and implemented a detailed timeline tracker to support the management of the pipeline.

Doctor Of Philosophy - Phd, Pharmaceutical Sciences

Bachelor'S Degree, Pharmaceutical Sciences

Summer Program, Health Professions And Related Clinical Sciences, Other