Xing Wei Email & Phone Number

Redwood City, California, United States

Redwood City, California, United States

Current Roles:• Pharmacology lead in the development team of RMC-6291, a best-in-class mutant-selective KRASG12C (ON) inhibitor in clinical development.• Pharmacology lead in the development team of the post-DC-stage compound RMC-0708, a first-in-class mutant-selective KRASQ61H (ON) inhibitor.• Pharmacology lead in the development team of another two pre-DC-stage inhibitors.• Colorectal cancer organoid strategy lead in Translational Research• Biology lead in THREE MTA/SRA collaborations with academic laboratories. Research Experience:• Lead in vivo pharmacology studies in house and at CROs as the study director.• Efficacy study in human CDX/PDX models.• PK/PD analysis in xenograft models.• Combination strategy• Novel preclinical colorectal cancer model development including CDX, PDX, orthotopic model, metastatic model, GEMM-derived tumor organoid syngeneic model.• Novel preclinical NSCLC cancer model development• Resistant model development• Novel PD assay development including Jess, GeoMx, ddPCR, multiple IHC etc.Conference Presentation：• Oral presentation in RAR 2023 off-site research conference of Revolution Medicines• Oral presentation (RMC-6291+RMC-6236 combo in KRAS G12C NSCLC) in AACR anual meeting 2024

Seattle, Us

Grant: Early Investigator Research Award (Department of Defense, U.S., Jan. 2020~Jan. 2022)Pre-selected publications:https://scholar.google.com/citations?user=LcwpwKAAAAAJ&hl=enResearch Experience:(1) Project Title: Regulation of Prostate Epithelial Homeostasis• Investigated the role of stromal Wnt signaling in prostate development and homeostasis.• Developed a novel approach on prostate tissue clearing and open-top light-sheet 3D imaging.• Demonstrated the developmental dynamics, maintenance mechanism, and heterogeneity of the Lgr5+ stromal cells in the prostate.• Investigated how loss of Lgr5+ stromal cells and altering mechanical force affect benign prostatic hyperplasia (BPH) progression.(2) Project Title: A Systematic Approach for Targeting WNT Signaling in Metastatic Prostate Cancer• Determined the spatial expression of specific WNT pathway components and presence of WNT pathway activity in human advanced prostate cancers.• Investigated how stromal Wnt signaling affects prostate cancer progression using transgenic mouse models.Conference Presentation:• Oral presentation in the Pacific Northwest Prostate Cancer Specialized Program of Research Excellence (SPORE) Conference.• Poster presentation in the annual SBUR conference. • Oral presentation in the UW Urology Research Conference.

Greater Houston

Research Experience:Project Title: Regulation of Prostate Epithelial Homeostasis(1) Investigated the role of CD133 (Prominin-1) as a putative prostate epithelial stem cell marker and its function in the prostate development.• Experimental design, troubleshooting, experimental notes writing, and manuscript writing under the mentorship.• Execute the experiments, including transgenic mouse models, mouse survival surgery, RNA in-situ hybridization, prostate sphere/organoid culture, gene cloning/subcloning, flow cytometry and cell sorting, qRT-PCR, cytospin and immunofluorescence staining, immunohistochemistry, western blots, and data analysis. (2) Studied the role of stromal Wnt signaling in prostate stem cell niche.• Experimental design, troubleshooting, experimental notes writing, and manuscript writing under the mentorship.• Execute the experiments as the team lead with two postdocs, including transgenic mouse models, human prostate FFPE specimen preparation, in vitro and in vivo small molecule analysis (BrdU, tamoxifen, IWP-2, Wnt3a, Wnt5a, Tgfb1/2/3), primary/prostate cancer cell culture, flow cytometry and cell sorting, RNA/DNA purification and qRT-PCR, RT2 Profiler PCR array, laser-capture microscopy, gene overexpression/knockdown, prostate sphere/organoid culture, mouse survival surgery, RNA-sequencing, CHIP-PCR assay, western blots, histology and immunostaining, confocal microscopy, and data analysis. Conference Presentation:• Poster presentation in the Gordon Research Conference. • Poster presentation in the Keystone Symposia--Stem cell and cancer (C1).• Oral and poster presentation in the annual IMBS program retreat at Baylor College of Medicine.

Hefei, Anhui, China

Project Title: • Screen the Binding Partners of Haspin Using Yeast Two-hybrid and Investigate Its Kinase Ac-tivity Regulation• Spatiotemporal Analysis of Haspin’s Kinase Activity Dynamics in Mitosis Using FRET-Based Sensors

Doctor Of Philosophy - Phd, Cell/Cellular And Molecular Biology

Professor John J. Trentin Scholarship (Oct. 2013) The Claude W. Smith Fellowship Award (Aug. 2013)

Bachelor'S Degree Of Science, Biosciences, Gpa 3.94

Top rank student of the School of Life Science of USTC. National Encouragement Scholarship (Oct. 2011) National Encouragement Scholarship.