Dr. Xosé R. Bustelo is a Full Research Professor at the Spanish National Research Council (Consejo Superior de Investigaciones Científicas, CSIC), the main scientific institution of the Spanish central government. He also holds a principal investigator position at the Cancer Biomedical Research Center (Centro de Investigación Biomédica en Red de Cáncer, CIBERONC), a Spanish government–sponsored multicenter initiative aimed at promoting cooperative work in both basic and clinical research among the 50 top–rated cancer labs in Spain.Dr. Bustelo’s scientific training includes a Ph.D. in Biology from the University of Santiago de Compostela (Galicia, Spain, 1990) and a postdoctoral stint at the Bristol–Myers Squibb Pharmaceutical Research Institute (Princeton, NJ, USA; years 1990–1993). He then worked as Staff Scientist at the Bristol–Myers Squibb Pharmaceutical Research Institute (Princeton, NJ, USA; years 1993-1996), as Assistant Professor at the Department of Pathology of the State University of New York at Stony Brook (Stony Brook, NY, USA; years 1996–2000) and, subsequently, as both CSIC Tenured (1999–2004) and Senior Research (2004–2005) scientist at the Cancer Research Center (Centro de Investigación del Cáncer, CIC) of Salamanca (Spain).Dr. Bustelo’s work has been traditionally focused on the understanding of the early signaling mechanisms that contribute to both cancer development and other high- incidence diseases. His research group has identified genes involved in those processes, new protumorigenic biological programs present in cancer cells, drug targets, and diagnostic signatures of clinical interest for patients. Dr. Bustelo’s scientific production includes 160 scientific articles and nine patents up to now. His scientific contributions are highly cited (more than 15,000 citations, h index = 62), being listed among the 0.5% of most cited scientists at the worldwide level.His work has been recognized by a number of both Spanish and international scientific awards, including the Catacosinos Young Investigator Award for Cancer Research (USA), the Sinsheimer Award (USA), the Carol M. Balwin Award for Breast Cancer Research (USA), the Echevarne National Oncology Award (Spain), Pfizer Award on Basic Research (Spain), the Severo Ochoa Award on Biomedical Research (Spain), and the Galician of the Year Award (El Correo Gallego Media Group, Spain). In 2020 and 2021, he has been included as member of the Royal Galician Academy of Sciences and the Royal Academy of Pharmacy of Galicia, respectively.