1.Design, producing and management of DNA-encoded libraries based on privileged scaffolds and macrocyclic rings. 2. External collaboration

Design and develop DNA-encoded chemical libraries to identify hits for biologically interesting targets. Employ skills from traditional organic chemistry, molecular biology and bioconjugate chemistry to develop DNA-compatible organic reactions for DNA-encoded small molecular combinatorial libraries production by the split-and-pool strategy. Perform hit identification and hit-to-lead optimization to deliver high-quality small molecular inhibitors for early drug discovery programs.