Lead studies in molecular mechanism of Rett Syndrome pathology, amylin aggregation in Diabetes II and DNA base damage reparation. Emphasis on molecular biology studies in particular projects.Clarified and improved the models proposed by computational collaborator, while investigatingeffects of small molecule on hIAPP/amyloid-beta aggregation.Conducting preliminary data and proposing experimental design for new grants application.Train undergraduate interns and graduate students in recombinant proteinpurification, circular dichroism and ABI DNA sequencer.

Lead studies on two uncharacterized SUMO/ubiquitin E3 ligases act antagonistically to determinecrossover/non-crossover during mouse meiosis, by recombinant protein from insect cell andmammalian cells expression system in vitro analysis, such as pull-down assay, quantitativewestern blotting, MS and, and in vivo analysis, such as quantitative Western blotting,immunoprecipitation analysis, RT-qPCR and MS-based proteomics with mouse tissues andyeast cell cultures.Conducted antibody preparation and purification for ELISA, Western blottingimmunofluorescence, and immunoprecipitation analysis.Trained rotation graduate students in recombinant protein purification from insect cells and mammallian cells.