Yanming Tan Email & Phone Number

Auckland, New Zealand

1) Process Improvement - Lead and conducted effective investigations into production quality issues, errors and/or mistakes. - Sustainable solutions are developed, introduced and applied to resolve issue or to prevent subsequent reoccurence. - Facilitated a team to improve on Packing procedures which resulted in significant cost savings (~NZD40,000) using the DMAIC methodology. - Currently working towards obtaining Lean Six Sigma (Green Belt) Certification under ISO 18404:20152) Project Management - Provide Technical and Project Services support to Capital or Operational expenditure projects3) Management of Production Documentation and Data - Prepare, review, update and coordinate approval of production documentation in a timely manner. - Plan and undertake development of documents for new products, processes or equipment.

Singapore

* Establishment of a cell based assay to study the effect of viral quasispecies on disease progression* Supported departmental and laboratory’s safety and compliance requirements.• Chemical spill response member

Singapore

Reported to the Manufacturing manager and am responsible for the manufacture of therapeutic cell products under cGMP conditions.* Developed competency in performing all operational tasks independently in the manufacturing areas.* Regular use of Standard Operating Procedures, recording of logbooks and batch records which conforms to GDP.* Assisted the Manufacturing Science and Technology (MSAT) department in Process Development studies to increase product yield or investigate problems to enable robust operations.* Collaborated with the Manufacturing Science and Technology (MSAT) department to investigate manufacturing deviations.* Initiated and follow through with new document/SOP generation and change requests. • Generated new SOP and streamlined the procedure. • Overhauled the logbook format for better tracking of inventories.

Singapore

Reporting to the Head of Biology and functionally to the Program leader. Responsible for producing data/ assays which drive compounds through the screening cascade in the search for a therapeutic drug.* Determine the pharmacological activity of newly synthesized chemical compounds independently on a weekly basis in a lead optimization program - Screening of over 100 compounds per month in plate based small molecule pharmacology assay - Techniques include calcium flux (FLIPR) assays, euthanasia of animals and tissue collection, isolation of organelles from various tissue types for eg. Liver, Brain, Heart etc - Instrumental in the generation of high quality data which conforms to strict Quality Control requirements - Key point of contact for Chemistry team to approach with queries regarding compound activity* Development and validations of new assays/methodology - Creation of a new methodology to isolate mitochondria from human cell lines for program’s needs. - Independently develop high quality in-vitro assays for target validation.* Lead user for FLIPR machine and pH meter - Schedule calibration and preventative maintenance for the equipments - Diagnose equipment errors and restore it to optimum state* Ensure meticulous record keeping which conforms to regulatory requirements* Manage multiple projects simultaneously - Assign priorities to experiments - Completion of experiments under critical timeline

Singapore

Reported to the Principal Investigator and functionally to a research supervisor.Supported two post-doctorate research fellows with their projects by providing technical expertise to discover novel genes that affect quorum sensing.* Redesigned the experimental conditions required for biofilm formation by bacteria - Determined growth rate and optimum growth conditions of bacteria - Refined the concentration of antibiotics needed to induce biofilm formation* Discovered genes, as part of a team effort, which affects biofilm formation - Employed a wide range of techniques which included molecular cloning, plasmid amplification and purification, subcloning, protein isolation and western blots - Well versed in virulence assay which utilize Caenorhabditis elegans as model organism* Highly skilled in the following techniques: - Performed Polymerase chain reaction(PCR) to amplify DNA fragments for various uses. - Transfer of plasmid from E.coli to Pseudomonas Aeruginosa - Western Blots

Bachelor'S Degree, Microbiology, General

Graduated with a Bachelor of Science with Majors in Microbiology and Molecular Cell Biology.

Diploma, Biotechnology

Activities and Societies: 1) Executive committee for Temasek Polytechnic's Community Service Club. I organized various activities which.