Yasir S. R. Email and Phone Number

Medicinal Chemistry:• Team lead within oncology-focused hit expansion/lead optimization program (3 FTEs)• Extensive involvement in 4 drug discovery programs (with successful track-record)• Consulted on lead optimization screening cascade, and prioritizing of structural analogs• Assisted in the design, execution, and optimization of multi-step synthetic schemes• Proficient in the use of SBDD CADD software: Maestro (Glide), ChimeraX/1.16, PyMOLSynthetic Chemistry:• Diverse amide coupling strategies (EDC, DCC, DIC, HATU, HBTU, TCFH, etc.)• Transition metal-catalyzed cross-couplings: Pd, Ni, Fe, Cu (C-C, C-N, C-S, C-O, etc.)• Protection/deprotection reactions, reductive aminations, and nucleophilic substitutions• C-C bond formation via Grignard and/or organolithium reagents (MeLi, nBuLi, tBuLi, etc.)Business Development:• Supported functional leads to generate robust, and marketable data for client acquisition• Assisted company in acquiring new clients (secured >100K USD in research funding)• Published weekly “Small Molecule Highlights” blog series on LinkedIn (1000+ followers)

• Synthetic medicinal chemist within oncology programs targeting PPIs, GPCRs, and TFs• Multi-step syntheses, parallel syntheses, purifications, and characterization (>45 APIs)• Extensive small-scale route-scouting (5-50 mgs), API scale-up (10-50g), and quality-control• Instruments: Biotage Isolera, Waters HPLC/LC-MS, Bruker NMR (400 MHz), FT-IR, MS• Initiated discovery group meetings: Research articles, techniques, and MedChem concepts

• Group-based 2-hour virtual study sessions for university students (50-100)• Topics: Organic chemistry, biological chemistry, and biochemistry• Teaching included background theory, problem sets, and exam preparation

Course: Organic Chemistry II (Year 2)• Ran tutorials and laboratory experiments for second-year chemistry students (20)• Topics: Nomenclature, functional groups, reactivity, reaction schemes, retrosynthesis• After-class study sessions before term tests (40-50 students)• Invigilated quizzes, term tests, and final examination• Graded laboratory reports, and term tests• Extensive positive-feedback on teaching style, methods, and philosophy

Course: Analytical Chemistry I (Year 2)• Instruct on analytical chemistry experimental set-ups, laboratories, and tutorials (20)• Topics: UV-Vis, IR, FT-IR, acids/bases, pH electrodes, potentiometry, redox titrationsCourse: Organic Chemistry II (Year 2)• Ran group-based tutorials, and guest lectures on topics in organic chemistry (20-250)• Topics: Advanced retrosynthesis, synthetic transformations, R, S-stereochemistryCourse: Metabolism and Bioenergetics (Year 3)• Group-based tutorials on various topics in human metabolism and energetics (25)• Topics: Metabolic cycles, ATP synthesis, Bohr effect, G1-S-G2-M cell cyclesCourse: Techniques in Biological Chemistry I, II (Year 3)• Group-based laboratories on advanced techniques in biological chemistry (20)• Topics: Recombinant DNA, SDS-PAGE, protein purification, structural biologyCourse: Introduction to Medicinal Chemistry (Year 4)• Ran tutorials and guest lectures on various aspects of drug discovery (45)• Topics: Molecular recognition, drug targets, metabolism, PK/PD, Covalent inhibitors• Guest lecture: Kinase-specific targeted covalent inhibitors

Overview:• Graduate doctoral studies with Prof. Patrick Gunning, GPA: 4.0• Specialized in medicinal chemistry, molecular recognition, and pre-clinical drug discovery• Fields of study: Organic, biological, computational chemistry, and oncology drug design• Expertise: SBDD, H2L, chemical synthesis, epigenetics, blood cancers (AML, T-PLL, CTCL, MM)Thesis: Development of novel histone deacetylase inhibitors for the treatment of blood cancers*Awarded Fraser Code PhD Thesis Award (University-wide)• Developed highly-potent, and selective, pre-clinical inhibitors of epigenetic drug targets• Single-digit nM potency, with ex vivo efficacy in a patient-derived tumor model• Designed a first-in-class inhibitor of an epigenetic target via a novel binding mechanismPublication/Patent Record:• 8 publications in highly-cited journals (JMedChem, ChemSocRev, ACS MedChem Lett)• >200 citations (as of 2019), Top 10 most-cited articles in research group• >3 manuscripts in-process of submission• 1 patent as an inventor (US20220169598A1)Awards:• Fraser Code PhD Thesis Award: 1,000 CAD• Ontario Graduate Scholarship (OGS): 15,000 CAD• PhD Doctoral Completion Award: 500 CAD• Max’s Big Fellowship on Research in Duchenne Muscular Dystrophy: 13,000 CAD• Jesse’s Journey Research Grant in Duchenne Muscular Dystrophy: 300,000 CAD• MedChem Residential School Best Presenter Award: 300 CAD• Target Discovery using Chemical Probes Best Presenter Award: 300 CAD• Andrew Robertson Gordon Fellowship: 1,000 CAD• Graduate Summer Research Fellowship: 5,000 CADConferences:• Target Discovery using Chemical Probes, Oxford University, UK*• Medicinal Chemistry Residential School, Loughborough University , UK*• Master Medicinal Chemistry, Boston, Massachusetts, USA*Awarded "Best Presenter" certificateSeminars:• Kinase-specific targeted covalent inhibitors, University of Toronto, Canada• Isoform-specific HDAC inhibitors to treat blood cancers, University of Toronto, Canada

• Ran group-based 4-hour study sessions for MCAT students (40-50)• Topics: Organic chemistry, biochemistry, and general chemistry• Teaching included theory, problem-solving, and passage analysis• 5-scale satisfaction rating: High average of 4.8/5.0

• Performed one-on-one teaching sessions with senior high school students (Grade 10-12)• Topics: Chemistry, biology, physics, and mathematics• Repeated positive feedback from students (>98% highly satisfied)• All students achieved admission into top Canadian universities (UofT, UW, McMaster)

Course: Chemical Principles I, Chemical Principles II (Year 1)• Ran tutorials and laboratory experiments for first-year chemistry students (20-25)• Gained teaching expertise in introductory topics in general chemistry• Invigilated quizzes, term tests, and final examination• Graded laboratory reports, and term tests for first-year students

3rd Year researcher in Prof. Patrick Gunning’s group via Research Opportunity Program (ROP)• Experience in organic, synthetic, computational, biophysical, medicinal chemistry• Synthesis design, reaction set-up, work-up, purifications, and characterization methods• Molecular docking analysis via AutoDock 4.0/AutoDock Vina, PyMOL analysis• Studies on oncogenic orphan kinase ROS-1 (implicated in non-small cell lung cancer)• Discovery of novel hits against this kinase (uM affinities) with cellular activity (BaF3)• Presentation of research efforts to department of chemistry (UofT)4th Year researcher in Prof. Patrick Gunning’s group via Thesis Honor’s Program Thesis: Biophysical Binding of Molecules to Orphan Kinase ROS1 Towards a Treatment for NSCLC• Assisted in the design, and execution of TR-FRET based LanthaScreens activity assay (Kd)• Lead a Group efficiency (GE) based fragment screen analysis of clinical standard Cabozantinib• Performed an in vitro characterization of novel molecular hits against CD74-ROS1• Presentation of research to department of chemistry (UofT) – Best presentation award

• Undergraduate degree at the University of Toronto in Life sciences (Distinction), GPA 3.75• Degree specialization: Chemistry, Biology (health sciences)• >40 courses in chemistry, physics, biology, mathematics, sociology, geology, philosophy• Extensive research-based experience as part of Prof. Patrick Gunning’s research group• Teaching experience of introductory chemistry courses (tutorials, laboratories, exams)• Sports: Intra-mural activities/varsity-based events/co-educational (soccer, volleyball)

• Provided course-specific teaching assistance to 80 undergraduates (chemistry, biology, math)• Ran weekly subject-specific help sessions (course material, problem sets, practical skills)• Tracked student performance over time (provided advice for improvement/maintenance)• >90% of students achieved desired grades to successfully progress into next year

• Helped in the social/educational progression of 40 residence students into university life• Managed student well-being: General needs, professional development, self-care, health• Organized weekly activity meetings, monthly one-on-ones, and bi-monthly group events• Successful employment by Student Housing department 2 consecutive years• Assisted in planning, operations, and coaching during new employee training programs

• Assisted in co-ordination of initiative donations across various locations in Dubai, UAE• Generated brochures on the impact of natural disasters on Haiti• Delegated distribution of information material to various donors during campaign