1. Managing a global team of bioinformatics analysts and engineers in building tools and pipelines for standardized and scalable NGS data analysis;2. Managing the team's efforts in communicating with customers and collaborators for developing innovative bioinformatics solutions;3. Serving as knowledge source for bioinformatics applications to multiple cross-department groups in technology and business development;4. Collaborating with lab scientists in experimental design, execution, analysis, and validation for development of proprietary NGS application platforms and product lines;5. Working with internal IT team in developing cloud-based applications for genomics data analysis.

1. Under current serving products and long-term planning, leading GENEWIZ China Bioinformatics (BI) Groups to establish, maintain and improve data analysis platforms.2. Taking responsible for group routine management, data analysis and storing.3. Following the current market opportunities and technologies development, planning BI pipelines development and maintaining of the NGS related products.4. Leading team to do technology support for other departments, such as Development department.5. Being involving in the development of Big data Cloud platform.

1. Establishment of analyzing pipelines for different NGS data based various computer tools including exon sequence data, transcriptomics data and small RNA data analysis. These sequence data are generated by 454 and Illumina Hiseq & Miseq platforms. The pipelines aim for the works in de novo, SNP detection, differential expression gene research and metagenomics analysis.2. Providing customized serving for VIP customers. According to the papers provided by them, always being Nature & Science journals series, designing similar math models and analysis software to deal with biological data offered by customers, providing final analysis reports and assisting the publications of customers' works.3. Development of novel NGS serving projects:◆ Adding UIDs to the fragments is reliable way to minimize PCR error during experiment step. As an important step, I charge with development the analysis pipelines for sequencing data, including DNA, RNA and metagenomic sequencing projects. ◆ Antibody Sequencing is very hot spot in current biological and medical research. By sequencing B cell DNA/RNA sequence located in variable regions through NGS platform, we can specially find the important DNA/RNA fragment being responsible for favored antibodies, which is called as B cell sequencing serving project. My work is to deal with sequencing reads to get a readable data, including QC, IgBlast analysis, CDR3 regions sequences identification and clustering. Moreover, I am also responsible for the developing whole analyzing work for FuzeSeq serving project which is novel experimental method to sequence antibody genes.

1. Using variant methods to collect drug data and developing a Adverse Drug Reaction database(ADR System) which can forecast potential risk of prescription.2. Designing a workflow in studying therapeutic mechanism of bioactive moleculars, including molecular virtual docking, analysis of biological pathways related targets.3. Using amber software to simulate the complex of HO-PBDEs and thyroid receptor; analyzing the hydrogen bonds formed between two molecules and RMSD value of key residents near the compound in the docking package; evaluating the various energies contribution on the stability of the complex. 4. Design of small molecule Keap1 inhibitors by virtual screening method (based Dock6 and MOE) for treating neurodegenerative disorders.5. Established a QSAR model for evaluating renal toxicity of small melocules.6. Builded numbers of Web platforms uitilized PHP and Mysql for managing and retrieving drugs' data.7. Collecting information about current studying drugs for treating melanoma. Gathering data from ClinicalTrial database, surveying studying drugs and corresponding targets information. Based on the work, I have written a review paper.8. Discussion with other colleagues commencing cell and protein experiments, understanding experimental process and giving some suggestions to dealt with problems in these experiments.

1. Finished the first public-available protein targets database of herbal active ingredients: HIT（Herbal Ingredients’Targets database, URL:http://lifecenter.sgst.cn/hit/ ）. The work includes：retrieving PubMed database to gather reported herbal compounds and corresponding targets utilizing textmining and manual check methods. The current version collected 5208 pairs of compounds and targets from 3256 papers, which are associated with >1300 herbs, 586 active compounds and 1301 targets. 2. Establish novel biological network method to analyze drug pharmacology. The method based on the relation between biological pathways and renders new vision of pathway to study treating mechanism of small molecule drugs which can hit more than one target. The work is published in journal 《Chinese Science Bulletin》 as cover paper.3. Comparing mechanisms of western drugs and TCM in treating CVDs. The work collected targets related treating CVDs and studied these targets’characters including interfering pathways and gene expression distinctions。The work found that most targets of western drugs located in cytomembrane, while most targets belong to TCM are in cytoplasm and owned high percentage belonged to transcription factors.