Ye Shen Email & Phone Number

Seattle, WA, US

Lawrence Township, NJ, US

Lawrence Township, NJ, US

• Serve as the clinical biomarker lead for multiple T-cell engager (Alnuctamab) and CAR T (ide-cel and liso-cel) programs ranging from Phase I exploratory trials to Phase III registrational trials.
• Partner with discovery groups to develop biomarker strategies in preparation for IND application and FIH studies of assets in solid tumor.
• Design and direct biomarker plans, work with CROs to ensure execution of biomarker assays, generate and deliver biomarker data to support clinical decision making and pre-clinical pipeline development.
• Collaborate with various functions (clinical operations, pharmacology, biostatistics, etc.) to author clinical documents such as protocol, statistical analysis plan, response to information request from health.
• Lead discovery projects with bioinformatic groups to analyze and interpret clinical biomarker data. Communicate translational learnings with internal pre-clinical teams and external collaborators to advance.

Thousand Oaks, CA, US

• Led discovery projects to unravel BiTE mechanisms of action, novel biomarkers and combination strategies.
• Designed and conducted genome-wide CRISPR loss-of-function and CRISPRa gain-of-function screens to identify resistance mechanisms of cancer cells to BiTE-mediated T-cell cytotoxicity. Independently performed data.
• Conducted in vitro T-cell cytotoxicity assays and in vivo efficacy studies to demonstrate perturbation of multiple co-stimulatory ligands and apoptosis pathway as cancer cell intrinsic mechanisms to evade T cell.

Houston, Texas, US

• Directed an independent project to investigate the function of KLF4 and its downstream MAP2K7-JNK signaling in T-cell acute lymphoblastic leukemia.
• Initiated the generation of PDX models in the lab and utilized the models to evaluate effects of small molecule inhibitors targeting JNK pathway on human leukemia progression in vivo.
• Established and expanded the Patient-Derived Xenograft (PDX) repository in the lab to further study essential signaling pathways in T-cell leukemia in vivo.
• Cooperated with lab colleagues to study the development of T cells in thymus, and homeostasis and differentiation of CD8+ T cells using loss-of-function mouse models.
• Spearheaded multiple collaborative projects with TCH clinical teams, industry, and international institutes for pre-clinical testing of novel therapeutic approaches for leukemia patients.
• Self-trained on GeneSpring and analysis of high content datasets (GEO, ArrayExpress, Oncomine, etc.).

上海, 上海市, CN

• Utilized a novel knockout mouse model in combination with flow cytometry, in vitro functional assay and immunoblot to study the role of a phosphatase PP6 in T cell development and function.
• Independently performed frozen sections and immunohistochemistry staining to investigate the expression pattern of a vacuole protein VPS18 in mouse brain.
• Extensively collaborated with lab colleagues and co-authored two peer-reviewed papers.

Doctor Of Philosophy - Phd, Hematology / Oncology, Immunology

Bachelor’S Degree, Biology, General