Yi-Han Lu Email & Phone Number

Taiwan

Atlanta, Georgia, United States

• Devise a procedure for triple-labeling stochastic optical reconstruction microscopy (STORM) imaging, facilitating the observation of envelope protein distribution on sub-resolution virions. Implement bio-orthogonal click labeling in conjunction with STORM imaging to mitigate the impact of fluorescence labeling on biological function and protein localization.• Utilize MATLAB scripts to integrate algorithms including DBSCAN, Kolmogorov–Smirnov test, and Fischer’s test for automated data analysis. • Supervise a computer science undergraduate student in developing a user-friendly interface tailored for researchers lacking coding expertise.• Exploit TrackPy, a Python library, for precise single particle tracking in 2D fluorescence microscopy images, enhancing research on virus invasion of host cells. Employ Hidden Markov Model fitting on time series data extracted from TrackPy analysis to identify distinct behaviors during virus invasion.• Create custom programs with Python for fluorescence intensity and lifetime bulk analysis, enabling user-friendly data visualization and fast statistical analysis for laboratory members without coding expertise.• Coordinated with microscope suppliers to develop commercial solutions for advanced microscopy image analysis.• Maintained microscopes and communicated with suppliers as needed for maintenance and troubleshooting.

Atlanta, Georgia, United States

• Pioneered the development of a novel two-photon fluorescent-based analytical instrument, supported by the derivation of fundamental mathematical expressions and Monte Carlo simulations of molecular behavior conducted through self-written Python scripts.• Synthesized nanoparticles and biomacromolecules of varying sizes to validate the effectiveness of this innovative system.• Conducted the synthesis of diverse silver nanoclusters and utilized spectroscopy and microscopy techniques to characterize their photophysical properties. Investigated the correlation between the emission wavelength of silver nanoclusters and the specific DNA backbone employed during synthesis.• Leveraged machine learning techniques to optimize the synthesis of fluorescence probes, enhancing efficiency and precision in probe development.• Managed and maintained laboratory devices including Ti-sapphire laser, power supply, frequency/delay generator, oscilloscope, photon diode, and photon counting module.• Mentored junior graduate students in developing research proposals and preparing publications.• Published the results in The Journal of Physical Chemistry B & The Journal of Physical Chemistry C.

Atlanta, Georgia, United States

• Worked as a TA in the physical chemistry lecture and general chemistry lab.• Prepared course materials such as lecture slides, handouts, and assignments.• Led the general chemistry lab sessions.• Graded assignments, exams, and other assessments according to established criteria.• Hold office hours to provide additional support and assistance to students.• Answered student inquiries via email or in-person during office hours.• Maintained records of student attendance, grades, and other relevant data.• Received the "Thank-a-Teacher Award" from the Center for Teaching and Learning at Georgia Tech in 2018 and 2019.• Served as Head TA for the Fall 2022 semester, overseeing other TAs and collaborating with the instructor to achieve course objectives and ensure smooth class activities.

Taipei City, Taiwan

• Employed molecular biology techniques to generate bio-samples for experiments and explored DNA packaging through single-molecule microscopy methods.• Developed MATLAB scripts for 2D particle tracking, imaging analysis, and data analysis.• Published findings in Biochimica et Biophysica Acta and PLoS One.

Taipei City, Taiwan

• Created an enhanced silk degumming process to elevate brightness and smoothness while concurrently reducing costs and time compared to conventional methods.• Successfully scaled the laboratory procedure to factory-level production, optimizing it for efficient large-scale manufacturing.

Doctor Of Philosophy - Phd, Physical Chemistry

Master Of Science - Ms, Chemistry