Yi Zhou Email & Phone Number

Continue to develope antiviral drugs for patients

South San Francisco, California, US

South San Francisco, California, US

Cure for HBV

Boston, MA, US

• Played key roles in anti-influenza project from hit identification to preclinical study.­ Served as biology/virology member on the lead in anti-influenza project teamcommittee that ultimately to ensure the project.
• Performed genotypic and phenotypic studies of HCV variants with mutations conferring VX-950/Telaprevir resistance. ­ Developed a 9 kb HCV genome RT-PCR with detection limit of 1,000 copies/ml from patient serum.
• Wrote scientific papers, project proposals, FDA reports and VX-787 IND application.
• Excellent verbal and written communication skills and a strong collaborative spirit.
• Supervised and mentored BS, MS and PhD level scientists.
• Honors­ 2009 Vertex Outstanding Research Award Nominee­ 2012 Vertex Outstanding Research Award Nominee and was selected to present to Vertex’s board of directors.

Boston, MA, US

New York, New York, US

• Coordinated, supervised and conducted the development of cell based high through put screenHTS assays for antiviral drug discovery. ­ Generated viral reporter replicons (a self-replicating viral RNA in a host cell) for.
• Validated protein ELISA and RNA ELISA for high throughput screening.
• Wrote and received Small Business Innovation Research (SBIR) grants.
• Trained and mentored junior scientists.

St. Louis, MO, US

• Developed episomal ecdysone inducible cell lines to characterize toxic HIV-1 Vpr protein nucleuars localization signal and study its G2 cell cycle arrest function.
• Expressed HIV-1 MA protein in bacteria generating polyclonal antibodies for the study of MA function study, and identified ????, a novel HIV-1 MA interaction protein by yeast two-hybrid system.
• Supervised the study of the HIV-2 Vpx-gag protein interaction.
• Performed radiation and chemical safety training for laboratory personals and new hires.
• Gained experience with protein characterization, FACs, in vitro protein binding assay, Ecodyson and Tet inducible gene expression systems, confocal microscope, virus propagation and various viral assays.

• Purified tumor specific/rich proteins from breast and lung tumor tissues to generate mouse monoclonal antibodies against breast and lung cancer.
• Purified human α-acid glycoprotein, generated monoclonal and polyclonal antibodies, and developed an ELISA kit to detect blood alpha-acid glycoprotein level.

Doctor Of Philosophy (Ph.D.), Virology

Virology

Master'S Degree, Biotechnology

Bachelor'S Degree, Microbiology, General

Education record