Oliver (Yi-Che) Chang, Phd Email and Phone Number

My research in Prof. Cliff Brangwynne's Soft Living Matter Group focused on bioengineering and genome biophysics. Published 4 papers in high-impact journals, including Cell (2X), Nature Cell Biology, and eLife.● Spearheaded a novel platform to study genome organization via biomolecular condensates by integrating CRISPR, optogenetics, and genomic imaging; published in best-in-field journal Cell (2018) with 500+ citations● Boosted gene-targeting efficiency by 10X for CRISPR-condensate platform by modularizing platform components● Co-authored 3 additional high-impact publications in Cell (2024, accepted), eLife (2024), and Nature Cell Biology (2020) by coordinating research timelines with 10+ researchersMy experience in bioengineering goes beyond implementing synthetic genes in mammalian cells and microscopy-based assay development. It also extends to integrated image informatics and scientific software development.● Reduced 90% of data-to-insight conversion time by streamlining cell-line development and image processing● Authored 1 pull request for open-source image reader ‘aicsimageio’ by refining metadata API implementation

● Achieved a 5X reduction in wait times for reagent ordering process by implementing digital solutions● Trained 13 lab members in cell culture techniques, tailoring instruction to diverse skill levels● Achieved training compliance rates of over 90% by optimizing onboarding processes for new hire

● Assess 3+ life science techs to identify potential licensees by preparing market research and licensing pitches● Analyzed competitive landscape for a technology, evaluating 20+ biopharmas in (pre)clinical and market stages● Examined 5-year M&A trends to prioritize potential technology licensees and buyers● Delivered 10-min briefing to senior leadership, outlining strategic BD recommendations for a patented technology

● Led General Chemistry discussion classes for undergraduates from diverse academic backgrounds, including humanities majors, ensuring accessibility for all students

Co-advised by Dr. Joseph J.-T. Huang and Dr. Yu-Ju Chen to engineer proteins with unnatural amino acids for application in glycoproteomics.● Established 2 QC protocols for protein purification and conjugation using mass spectrometry● Accelerated turnaround rate by 5X of external vendor services by introducing SOPs for sample preparation

● Examined oligomerization state of neurodegenerative diseases-related protein Htt and its interaction with chaperone proteins in Dr. Joseph J.-T. Huang's research group.

● Supervised 20+ undergraduate students for General Chemistry Lab

● Directed activities of 9 teams with 30 members, providing support services to autistic children and teenagers; pivotal in elevating community awareness and comprehension of autism through outreach campaigns● Created and facilitated 6 courses aimed at training participants on effective interaction with autistic children