Yichen Li

Yichen Li Email and Phone Number

Ractigen, Neuroscience @ Ractigen Therapeutics
nantong, jiangsu, china
Yichen Li's Location
Beijing, China, China
Yichen Li's Contact Details

Yichen Li personal email

n/a
About Yichen Li

Yichen Li is a Ractigen, Neuroscience at Ractigen Therapeutics. They possess expertise in cell, cell culture, stem cells, cell biology, neuroscience and 14 more skills.

Yichen Li's Current Company Details
Ractigen Therapeutics

Ractigen Therapeutics

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Ractigen, Neuroscience
nantong, jiangsu, china
Website:
ractigen.com
Employees:
6
Yichen Li Work Experience Details
  • Ractigen Therapeutics
    Associate Director Of Neuroscience
    Ractigen Therapeutics Sep 2024 - Present
    Suzhou, Jiangsu, China
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  • 先声药业
    Senior Research Fellow In Translational Neuroscience
    先声药业 Jan 2023 - Aug 2024
    北京
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  • University Of Southern California
    Postdoctoral Researcher
    University Of Southern California Jun 2018 - Dec 2022
    Los Angeles, California
    Using iPSCs from ALS patient to conduct phenotypic screen and develop ASO therapies.
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  • China Regenerative Medicine International
    Research Assistant
    China Regenerative Medicine International Nov 2017 - Jun 2018
    Oxford, United Kingdom
    -Developing improved 3D-printable bioreactors for brain organoid cultures
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  • University Of Oxford
    D.Phil In Neuroscience
    University Of Oxford Oct 2014 - Apr 2018
    -Studying neuronal development in schizophrenia by co-culturing patient-derived induced cortical neurons and microglia-Looking for De Novo mutations in patients without family history -Discovering mechanisms linking patients' genetic backgrounds with in vitro cellular phenotypes-Validating efficacy of candidate drugs on human induced cortical neurons-Communicating with clinicians to collect biopsies and managing cell bank
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  • Centre For Personalised Medicine, St. Anne'S College, University Of Oxford
    Mcr Representative
    Centre For Personalised Medicine, St. Anne'S College, University Of Oxford Oct 2015 - Oct 2016
    Oxford, United Kingdom
    -Participating in organising college/university events related to personalised medicine, representing graduate reading students from St. Anne's College
  • University Of Southern California
    Research Assistant
    University Of Southern California Jun 2013 - Sep 2014
    Los Angeles, California
    -Screened for small compounds that rescue the degeneration of patient-derived induced motor neurons-Performed longitudinal single neuron tracking-Worked with software engineers to develop automated neuron tracking method-Managed automated high-throughput imaging core and database
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  • University Of Southern California
    Mres Rotation Project
    University Of Southern California Jun 2013 - Oct 2013
    Los Angeles, California
    To study the pathogenesis of C9ORF72 mutation in Amyotrophic Lateral Sclerosis, we directly converted patients' fibroblasts into induced motor neurons and screen for small compounds that can rescue the survival phenotype.
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  • Imperial College London
    Mres Rotation Project
    Imperial College London Feb 2013 - May 2013
    Hammersmith Hospital, London, Uk
    To investigate the role of injury mechanism played in white matter damage in traumatic brain injury (TBI), I conducted cross-sectional study of the white matter tract integrity in 85 TBI patients, using whole brain Tract Based Spatial Statistics analysis and region-of-interest analysis of the fractional anisotropy map derived from Diffusion Tensor Imaging.
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  • Imperial College London
    Mres Rotation Project
    Imperial College London Oct 2012 - Jan 2013
    Hammersmith Hospital, London, Uk
    To study the relationship between amyloid deposition, cortical metabolic decline and cognitive impairment in mild cognitive impairment (MCI)—a transitional phase between normal aging and dementia, I compared longitudinal changes of glucose metabolism (labeled with 18F-FDG) and cognitive performance between amyloid positive (labeled with 18F-AV45) MCI patients and amyloid negative MCI patients, using region of interest analysis and whole brain Statistical Parametric Mapping analysis of the… Show more To study the relationship between amyloid deposition, cortical metabolic decline and cognitive impairment in mild cognitive impairment (MCI)—a transitional phase between normal aging and dementia, I compared longitudinal changes of glucose metabolism (labeled with 18F-FDG) and cognitive performance between amyloid positive (labeled with 18F-AV45) MCI patients and amyloid negative MCI patients, using region of interest analysis and whole brain Statistical Parametric Mapping analysis of the physiological maps gained from Positron Emission Tomography. Show less
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  • Barts And The London School Of Medicine And Dentistry
    Bsc Graduation Project
    Barts And The London School Of Medicine And Dentistry Feb 2012 - Aug 2012
    London, Uk
    To assess the regenerative potential of cMyc in cerebellum, I induced mild overexpression of cMyc, with Adeno-Cre, in CD133+ neural stem/ progenitor cell (NSPC) cultures prepared from the cerebellum or subventricular zone of postnatal STOPFlox-cMyc mice. I assessed the alteration of self-renewal potential, proliferation, multipotency and context dependent apoptosis of NSPC culture, and the cerebellar morphology, layer thickness and cell architecture of H&E stained mid-sagittal cerebellum slice… Show more To assess the regenerative potential of cMyc in cerebellum, I induced mild overexpression of cMyc, with Adeno-Cre, in CD133+ neural stem/ progenitor cell (NSPC) cultures prepared from the cerebellum or subventricular zone of postnatal STOPFlox-cMyc mice. I assessed the alteration of self-renewal potential, proliferation, multipotency and context dependent apoptosis of NSPC culture, and the cerebellar morphology, layer thickness and cell architecture of H&E stained mid-sagittal cerebellum slice from postnatal Nestin;STOPFlox-cMyc mice. Show less
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  • The Netherlands Institute For Neuroscience
    Internship And Minor By Research
    The Netherlands Institute For Neuroscience Feb 2011 - Feb 2012
    Amsterdam, The Netherlands
    To study the neuroprotective effect of neural stem cells in neurodegeneration and aging, I co-cultured post-mortem Alzheimer tissues and aged control tissues from the prefrontal cortex with rat embryonic neural stem cell, assessed the cell viability in co-cultured tissues and investigated the expression alteration of a set of genes. To test if the observed improved cell viability in the brain tissue and changes gene expression is reversible, I produced siRNA delivering viral vectors to knock… Show more To study the neuroprotective effect of neural stem cells in neurodegeneration and aging, I co-cultured post-mortem Alzheimer tissues and aged control tissues from the prefrontal cortex with rat embryonic neural stem cell, assessed the cell viability in co-cultured tissues and investigated the expression alteration of a set of genes. To test if the observed improved cell viability in the brain tissue and changes gene expression is reversible, I produced siRNA delivering viral vectors to knock down the expression of genes of interest. I validated the optimal siRNA sequence to use for the knocking down of positive control gene. Show less

Yichen Li Skills

Cell Cell Culture Stem Cells Cell Biology Neuroscience Confocal Microscopy Western Blotting Pcr Immunohistochemistry Molecular Cloning Cell Signaling Molecular Biology Neurodegeneration Physiology Qpcr Animal Models Fluorescence Microscopy Scientific Writing Cerebral Organoid

Yichen Li Education Details

Frequently Asked Questions about Yichen Li

What company does Yichen Li work for?

Yichen Li works for Ractigen Therapeutics

What is Yichen Li's role at the current company?

Yichen Li's current role is Ractigen, Neuroscience.

What is Yichen Li's email address?

Yichen Li's email address is yi****@****usc.edu

What schools did Yichen Li attend?

Yichen Li attended University Of Oxford, Imperial College London, Han University Of Applied Sciences.

What are some of Yichen Li's interests?

Yichen Li has interest in Cellular Reprogramming, Schizophrenia, Traumatic Brain Injury, Neurodegenerative Diseases.

What skills is Yichen Li known for?

Yichen Li has skills like Cell, Cell Culture, Stem Cells, Cell Biology, Neuroscience, Confocal Microscopy, Western Blotting, Pcr, Immunohistochemistry, Molecular Cloning, Cell Signaling, Molecular Biology.

Who are Yichen Li's colleagues?

Yichen Li's colleagues are Fei Zhu, Jichao H., Zubao Gan, Yuheng Cai, 胡幼培, Xingchun Zhou, 潘晓洁.

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