Yichen Li Email & Phone Number

Suzhou, Jiangsu, China

北京

Los Angeles, California

Using iPSCs from ALS patient to conduct phenotypic screen and develop ASO therapies.

Oxford, United Kingdom

-Developing improved 3D-printable bioreactors for brain organoid cultures

-Studying neuronal development in schizophrenia by co-culturing patient-derived induced cortical neurons and microglia-Looking for De Novo mutations in patients without family history -Discovering mechanisms linking patients' genetic backgrounds with in vitro cellular phenotypes-Validating efficacy of candidate drugs on human induced cortical.

Oxford, United Kingdom

-Participating in organising college/university events related to personalised medicine, representing graduate reading students from St. Anne's College

Los Angeles, California

-Screened for small compounds that rescue the degeneration of patient-derived induced motor neurons-Performed longitudinal single neuron tracking-Worked with software engineers to develop automated neuron tracking method-Managed automated high-throughput imaging core and database

Los Angeles, California

To study the pathogenesis of C9ORF72 mutation in Amyotrophic Lateral Sclerosis, we directly converted patients' fibroblasts into induced motor neurons and screen for small compounds that can rescue the survival phenotype.

Hammersmith Hospital, London, UK

To investigate the role of injury mechanism played in white matter damage in traumatic brain injury (TBI), I conducted cross-sectional study of the white matter tract integrity in 85 TBI patients, using whole brain Tract Based Spatial Statistics analysis and region-of-interest analysis of the fractional anisotropy map derived from Diffusion Tensor Imaging.

Hammersmith Hospital, London, UK

To study the relationship between amyloid deposition, cortical metabolic decline and cognitive impairment in mild cognitive impairment (MCI)—a transitional phase between normal aging and dementia, I compared longitudinal changes of glucose metabolism (labeled with 18F-FDG) and cognitive performance between amyloid positive (labeled with 18F-AV45) MCI.

London, UK

To assess the regenerative potential of cMyc in cerebellum, I induced mild overexpression of cMyc, with Adeno-Cre, in CD133+ neural stem/ progenitor cell (NSPC) cultures prepared from the cerebellum or subventricular zone of postnatal STOPFlox-cMyc mice. I assessed the alteration of self-renewal potential, proliferation, multipotency and context dependent.

Amsterdam, The Netherlands

To study the neuroprotective effect of neural stem cells in neurodegeneration and aging, I co-cultured post-mortem Alzheimer tissues and aged control tissues from the prefrontal cortex with rat embryonic neural stem cell, assessed the cell viability in co-cultured tissues and investigated the expression alteration of a set of genes. To test if the observed.

Doctor Of Philosophy (Phd), Neurobiology And Neurosciences

Activities and Societies: Department of Physiology, Anatomy and Genetics Using patient-derived induced pluripotent stem cells to study the.

Master Of Science (Msc), Neuroscience

Bachelor Of Applied Science (B.A.Sc.), Biochemistry, Virology