Yoana Throssell Email & Phone Number

Milford, Massachusetts, United States

Analysis of actives and impurities in various consumer products via GC-FID, GC-MS, LC-MS, HPLCMethod optimization and development for small moleculesExperience with Agilent and Waters systems Experience with LIMS, Labware, Masshunter, Empower

Developed novel asymmetric Interrupted Feist-Bénary (IFB)-like reactions of electron-rich phenols with 1,2,3-triones for access to a novel class of potential antiviral therapeutics Developed LC and chiral HPLC separation methods to evaluate enantiopurity of IFB targetsSynthesized cinchona alkaloid chiral catalystsAssembled a tetracyclic antiviral unnatural product’s core by late stage functionalization of a previously unreported chiral dihydrohydroxyfuranPerformed transition metal catalysis for selective benzylic C-H activation of a library of chiral IFB adducts towards the asymmetric synthesis of anti-cancer drug rocaglamideSynthesized BINOL derived Brønsted acid catalysts for desymmetrization of achiral hemiacetalsPerformed Lewis acid catalyzed asymmetric C-H activation of achiral hemiacetalsSynthesized (py)box derived chiral catalysts for C-H activationPrepared anti-cancer rocaglamide analogs for cytotoxicity cell assaysPerformed reaction optimization and troubleshooting.Characterized reaction products by 1H, 13C NMR, GC-MS, HPLC and polarimetryMaintained lab instrumentation, inventory and safety Trained and supervised junior graduate and undergraduate students

Taught undergraduate laboratory courses: general, organic and integrated chemistry.Assisted students in reaction setup and analysis of results.Analyzed student samples by 1H, 13C NMR and GC-MS.Graded course assignments and held office hours to assist students with homework.

Greater Boston Area

Participated in the development and design of ophthalmic pharmaceutical formulations, drug characterization and analytical method development, ocular formulation stability studies and eye-drop characterization.

Department Of Chemistry

Taught organic and general chemistry laboratory sections of 16-18 students, graded weekly assignmentsProctored and graded exams; held weekly help sessions to provide individual assistance with course content

Department Of Pathology

Assessed dose-dependent cytotoxic and mutagenic effects on human lung epithelial cells exposed to nickel and cobalt chloride via clonogenic survival assays and western blot analysisExamined mechanism of genotoxic signaling by constructing a temporal profile of p53-regulated gene activation

Academic Deans Office

Maintained confidential student records, organized departmental databases, scheduled appointments, oversaw organization of academic eventsFacilitated interdepartmental communication, served as a liaison between faculty, students, relatives and alumnae.

Biology Department

Investigated the expression of Inhibitor of Apoptosis (diap2) in fat body remodeling in Drosophila melanogaster through Quantitative Real-Time PCR; developed a model for the gene’s temporal regulation in early developmentProposed a role of diap1 in remodeling chronology and pupal viability via fluorescence imaging of tissue-specific loss-of-function GFP-diap1 Drosophila

Department Of Biology

● Trained students in molecular biology techniques in a bioinformatics analysis of the human TAS2R38 gene● Instructed class in transmission genetics methods in linkage mapping of Drosophila genetic markers

Department Of Chemistry

● Supervised sections of 20+ students in conducting experiments; graded weekly lab assignments ● Provided problem-solving advice to students; clarified key concepts from lecture material in individual tutoring sessions; cooperated with lab instructors to accommodate each student’s academic needs

Department Of Chemistry

● Designed and implemented undergraduate analytical chemistry experiments in forensic investigation of fabric dyes; developed procedures for extraction and chromatographic separation; performed qualitative microscopic and spectrometric analysis ● Created and presented a research poster at campus-wide Summer Research Symposium in July, 2010; presented findings at the 241st National ACS Meeting in Anaheim, CA in March, 2011

Department Of Pharmacology

● Investigated Na+/K+ ATPase mutations in human rapid-onset dystonia parkinsonism in a Drosophila model; employed the GAL4 driver/UAS promoter system to create 50 transgenic strains● Isolated and identified mutations by PCR; assessed mutation severity by heat-shock and stress-sensitivity tests

● Conducted bioluminescence tests with Vibrio fischeri to evaluate the toxicity of soil samples from the Kremikovtzi metallurgical area in Sofia● Applied partial ranking theory to analyze heavy metal content of lake sediments from Turawa Lake, Poland

Faculty Of Pharmacy

● Evaluated the purity of commercially available aspirin brands via UV-Vis spectrometry and near IR-reflectance; identified and quantified aspirin contaminants; presented findings at a formal lecture to faculty members● Determined undeclared concentration of allergenic tartrazine in baby food through extraction, reversed-phase chromatography and fluorimetry; systematized results and assisted mentor in preparing poster presentation

Doctor Of Philosophy (Phd), Chemistry

Master Of Arts, Chemistry

Activities and Societies: Sigma Xi Scientific Research Society, American Chemical Society, American Society for Pharmacology.

Bachelor Of Arts, Chemistry

Activities and Societies: Student Government Association Senator, Mount Holyoke News Health and Science Section Staff Writer.