Yong Chang Email and Phone Number
I have a Ph.D. in Biophysics with strong background in molecular biology, biochemistry, biophysics, and enzymology with more than 10 years of research experience. I am thrilled by the breakthrough discoveries in the field of genomics, biotech and biomedical research. After my postdoc at UCLA, I pursued my career in industry in the related areas. Currently, I worked at HitGen Ltd, which focused on using a unique DNA encoded chemical library platform for early drug discovery research. Before that, I worked at Celula China Med-technology CO., Ltd (Nahaibio), which mainly engaged in cutting-edge genetic diagnostics, and biomedical research.SKILLS SUMMARY• Expertise in team management and project management• Extensive experimental skills for molecular cloning, DNA/protein biochemistry and Biophysics: (1) Vast experience in state-of-the-art technology for capturing protein-protein and protein-nucleic acid interaction; (2) Expertise in molecular design and application of DNA encoded library; (3) Expertise in Genetic diagnosis, liquid biopsy and Single cell analysis (NGS, qPCR, digital PCR, single cell amplification，genotyping)• Expertise in lab automation and system integration for procedure/pipeline: Beckman, Hamilton, Thermo, and Biodot systems• Expertise in various bioinformatic analysis tools: Various online sequence analysis and comparison tools, DNASTAR, Pymol, and UCSC Genome browser
Sansure Biotech Inc.
View- Website:
- sansureglobal.com
- Employees:
- 154
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Director Of Product DevelopmentSansure Biotech Inc.Chengdu, Sichuan, China
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DirectorSome Ivd Biotech Companies Jul 2020 - PresentChengdu, Sichuan, China- Reagent development for molecular diagnosis with unmatched needs in IVD and POCT area: e.g. multiplex molecular test, CRISPR in diagnosis, isothermal amplification for quick molecular test, reagent recipe development in lyophilised format for microfluidics- Sequencing: Oxford Nanopore sequencing project development, and other NGS projects
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Associate Director Of BiologyHitgen Ltd Apr 2017 - Jul 2020Chengdu, Sichuan, China• Have ever led three teams in the business unit with up to 17 people, including DNA encoded library (DEL) encoding team, Material QC/Production Support team, and Quality Assurance team. Supported the synthesis of >200 DNA encoded libraries with >400bn compounds in total.• Responsible of molecular biology part R&D of DNA encoded library synthesis: including methodology development, procedure optimization, routine project/ operation management, and DEL application expansion/innovation.• Lead DEL platform high-throughput instrumentation and operation improvement: (1) Routine high-throughput instrument support and management; (2) Lead the DEL whole platform automation/system integration project: worked with Hamilton and Thermo Fisher for the implementation of 3 modules of highly customized/integrated liquid handling systems. -
Biochemistry Group Leader / ManagerCelula, Inc/Celula China Med-Technology Co., Ltd Sep 2014 - Apr 2017Chengdu, Sichuan, China• Led Company’s Biochemistry research group of more than 10 people, and collaborated effectively with Cell biology group, Sequencing group and Bioinformatics group for product development:1) Co-Led and developed several products related to cancer and health management: 3 NGS screening panels for NSCLC targeted therapy diagnostics，5 health management products; 2) Led the single cell high-throughput analysis work to detect fetal cells separated from pregnant woman blood in non-invasive prenatal diagnosis (NIPD) project: successfully separated fetal cells from blood3) Expanded NIPD liquid biopsy experience in cancer related product development;4) Searched and evaluated new technologies in translational medicine and precision medicine to implement for internal projects• Supported company business development and marketing• Supervised lab safety and operation discipline
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Postdoctoral ResearcherUniversity Of California, Los Angeles Jul 2011 - Aug 2014California, United StatesMechanistic studies of DNA inversion reaction catalyzed by DNA invertasome, which is composed of multiple DNA elements and proteins. Publications:1.Chang Y., Johnson RC., Controlling tetramer formation, subunit rotation, and DNA ligation during Hin-catalyzed DNA inversion, Nucleic Acids Research, 2015, Jul 27;43(13):6459-72. 2.Li B, Krakow D, Nickerson DA, Bamshad MJ, Chang Y, Lachman RS, Yilmaz A, Kayserili H, Cohn DH. Opsismodysplasia resulting from an insertion mutation in the SH2 domain, which destabilizes INPPL1. Am J Med Genet Part A 9999:1–5, 2014.3.McLean MM*, Chang Y*, Dhar G, Heiss JK, and Johnson RC, Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion, eLife, 2:e01211, 2013. (*Join First Authors)
Yong Chang Skills
Yong Chang Education Details
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Biochemistry, Biophysics And Molecular Biology -
Biophyiscs And Structural Biology -
Biotechnology
Frequently Asked Questions about Yong Chang
What company does Yong Chang work for?
Yong Chang works for Sansure Biotech Inc.
What is Yong Chang's role at the current company?
Yong Chang's current role is Director of Product Development.
What schools did Yong Chang attend?
Yong Chang attended University Of Wisconsin-Madison, Tsinghua University, Sichuan University.
What skills is Yong Chang known for?
Yong Chang has skills like Research, Leadership, Biochemistry, Molecular Biology, Biotechnology, Real Time Polymerase Chain Reaction, Dna, Life Sciences, Polymerase Chain Reaction, Molecular Cloning, Protein Expression And Purification, Project Management.
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