Dr. Ernesto Fuentes Laboratory● Discovered CASK PDZ - pSDC1 interaction. This is the very first study showing positive regulationon PDZ - Syndecan interaction upon phosphorylation.● Successfully designed a PDZ domain mutant with desired peptide ligand specificity.● Confirmed newly identified cell polarity complex interaction (Scribble - SGEF) in vitro anddetermined a novel PDZ – internal PDZ binding motif interaction mechanism.● Determined 16 noble protein crystal structures (6 Apo structures and 10 ligand-bound complexstructures). Assigned 2 noble protein NMR HSQC profiles.● Developed structure based sequence alignment and structural motif extraction tools (computersoftware written in JAVA) for PDZ domains.● Initiated collaborative effort to utilize molecular dynamic simulation to design artificial PDZdomains de novo with Dr. Thomas Simonson, Ecole Polytechnique, France.● Collected experimental data and performed experimental validations to utilize polarizable forcefield molecular dynamic simulation to predict and design PDZ binding peptides, in collaboration with Dr. Michael Schnieders, University of Iowa, USA. ● Established membrane lipid bilayer mimicking Nanodisc system in Fuentes Lab.

99:241, Biophysical Chemistry I, 3 Credits, 48 Students

Structure Biology Laboratory.PI: Dr. Hyun Soo Cho● Worked on HMGB1 – ligand (CpG, LPS, RAGE, TLR4) complex structure determination

>Specialties- 81mm artillery / FDC / OP- Battalion logistics- Platoon leader / Medic- Reserved Army training support>Major operations participated- Key Resolve / Foal Eagle 2008, 2009- Exercise Ulchi Freedom Guardian 2008, 2009