Young-Tae Lee work email
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Young-Tae Lee personal email
I am a protein scientist with comprehensive experience in biochemistry, biophysics, protein science, and structural biology to study protein-ligand and macromolecular interactions, which has helped to address the mechanistic understanding of protein functions and supported drug discovery efforts. I love all biophysical and structural biology tools and embrace challenging problems to advance science and drug discovery.
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Senior ScientistAccent Therapeutics, Inc. Aug 2021 - Dec 2023Lexington, Massachusetts, Us- Gene to protein production to support hit finding, SBDD, anti-target profiling- Biophysics based hit finding activities such as ASMS screening- Hit validation and prioritization by SPR and crystallography- Establishment of robust crystallization systems for drug target proteins- Structure-based drug design -
ScientistAccent Therapeutics, Inc. Mar 2020 - Jul 2021Lexington, Massachusetts, Us- Advance chemical matter by structure-based drug design- Anti-target profiling by SPR- Biophysical characterization of protein-inhibitor interactions
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Research InvestigatorUniversity Of Michigan Jul 2015 - Dec 2018Ann Arbor, Michigan, Us- Developed integrative approaches by employing crystallography, small angle X-ray scattering, structural proteomics, NMR and cryo-EM- Determined cryo-EM structures of 400-kDa MLL1-nucleosome through collaboration- Investigated MLL1 subunit-subunit interactions using methyl-TROSY NMR, revealing novel MLL1 activation mechanisms through previously uncharacterized intrinsically disordered regions -
Postdoctoral ResearcherUniversity Of Michigan Sep 2013 - Jun 2015Ann Arbor, Michigan, Us• Developed a production protocol for 200-kDa nucleosome substrate• Production of 5-subunit H3K4 methyltransferase MLL1 complex
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Assistant Project ScientistUc Davis Mar 2011 - Jul 2013Davis, California, Us• Revealed dynamic conformational states of P450cam along the catalytic cycle and upon interaction with its redox partner Pdx using crystallography and EPR -
Research AssociateThe Scripps Research Institute Jun 2008 - Feb 2011La Jolla, California, Us• Solved a long-standing puzzle on substrate-free conformational state of P450cam• Captured crystallographic structural states during substrate channel opening process -
Postdoctoral FellowVanderbilt University Medical Center May 2002 - May 2008Nashville, Tennessee, Us- Determined NMR structures of S100A6 bound to regulatory proteins- Protein-protein interaction studies by NMR, ITC and mass spectroscopy -
Postdoctoral FellowKorea Institute Of Science And Technology Nov 2003 - Mar 2005Seoul, Kr• Structural biology on Fas-FADD death receptor signaling
Young-Tae Lee Skills
Young-Tae Lee Education Details
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Korea Advanced Institute Of Science And TechnologyChemistry
Frequently Asked Questions about Young-Tae Lee
What is Young-Tae Lee's role at the current company?
Young-Tae Lee's current role is Protein Scientist and Structural Biologist.
What is Young-Tae Lee's email address?
Young-Tae Lee's email address is yl****@****vis.edu
What schools did Young-Tae Lee attend?
Young-Tae Lee attended Korea Advanced Institute Of Science And Technology.
What skills is Young-Tae Lee known for?
Young-Tae Lee has skills like Protein Nmr, X Ray Crystallography, Epr, Small Angle X Ray Scattering, Protein Chemistry, Biophysical Chemistry, Structural Biology.
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