Yu-Li Wang Email and Phone Number
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Yu-li Wang's broad academic experience at institutions of basic science, medicine, and engineering allowed him to collaborate with an unusually wide range of professionals for interdisciplinary research, focusing on cellular mechanical activities. His contributions have catalyzed far-reaching conceptual changes in basic cell biology and regenerative medicine. He pioneered live cell imaging using fluorescently tagged proteins and discovered the frontal extension mechanism for cell migration. His research in cell division helped convincing the field to focus on the equatorial region for control signals. He introduced tunable, elastic polyacrylamide substrates for detecting and manipulating cellular mechanical interactions, which catalyzed a major transformation of the field of mechanobiology. In addition to the introduction of traction force microscopy, his group discovered the sensitivity of cell growth to material stiffness and the preferential cellular migration toward stiff surfaces termed durotaxis. His recent studies have elucidated the sensitivity of cells to their own size, shape, and migration state. In addition, the discovery of "contact following of locomotion" has filled a major gap about how cell-cell interactions regulate collective behavior. Yu-li Wang has published over 120 papers, several of which have received thousands of citations. His studies have been described in textbooks and his paper collected in the book “Landmark Papers in Cell Biology”. In addition, the books he edited have served as the defining technical resources for cell imaging and cell mechanics. He has also organized two international conferences and gave lectures internationally in the United States, United Kingdom, Canada, Austria, Germany, France, Sweden, Taiwan, Singapore, and Japan.
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R. Mehrabian Professor Of Biomedical EngineeringCarnegie Mellon UniversityPittsburgh, Pa, Us
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R. Mehrabian Professor Of Biomedical EngineeringCarnegie Mellon University Feb 2018 - PresentPittsburgh, Pa, UsI am now focusing entirely on research and education. While I continue to study cell migration and mechanical interactions, I am excited to blend science and engineering by incorporating such powerful tools as 3D printing and artificial intelligence for cell biology. I am also pursuing translational applications of our basic science expertise, in such areas as regenerative medicine and cancer diagnosis. A major discovery was "contact following of cell locomotion", which complements contact inhibition of locomotion for better understanding of cell collective behavior (2018 paper below). For teaching, I offer courses on biomedical applications of computation and electronics.
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R. Mehrabian Professor And Department Head Of Biomedical EngineeringCarnegie Mellon University Aug 2008 - Feb 2018Pittsburgh, Pa, UsAs Head of Biomedical Engineering, I valued the rare opportunity to nurture the growth of a young department. We have recruited faculty members who are both outstanding scholars and team players. We have turned our department into an interactive network that bridges science and engineering. Our graduate programs have grown in quality and size, and our dual major undergraduate program represents a new model for biomedical engineering education. Above all, I value our culture, where everyone feels valued and respected, comfortable to be him/herself.My research continued to focus on cellular mechanical interactions, using novel microfabrication approaches for probing cell behavior. We have seamlessly integrated experimental research and computational modelling for deep insight into the mechanism of mechanobiology.
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Professor Of PhysiologyUmass Medical School Jul 1997 - Jul 2008Worcester, Ma, UsWhile we continue to work on the coordination between cytokinesis and mitosis, much of our attention has shifted to the input and output of mechanical signals for regulating functions closely related to tissue engineering, wound repair, and cancer metastasis. A major discovery was durotaxis (2000 paper below), steering of the direction of cell migration by substrate stiffness. -
Principal ScientistWorcester Foundation For Biomedical Research Aug 1987 - Jun 1997My research was largely focused on cell division. We have expanded the microjection of fluorescent analogs to include functional protein domains or mutated proteins for probing the mechanism. In addition, success in the use of polyacrylamide as cell culture substrate led to the high impact discovery of cellular rigidity sensing (1997 paper below), which opened a new chapter in research.
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Staff ScientistNational Jewish Health Aug 1982 - Jul 1987Denver, Co - Colorado, UsThe research of my group was focused on the dynamics of actin cytoskeleton in muscle and non-muscle cells. We microinjected fluorescently tagged functional proteins as markers, an approach developed during my PhD research and served as the precursor for the GFP technology. A major discovery was the actin treadmilling at the leading edge, as the driving mechanism for cell protrusion (1985 paper below).
Yu-Li Wang Skills
Yu-Li Wang Education Details
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Harvard UniversityBiophysics -
National Taiwan UniversityPhysics
Frequently Asked Questions about Yu-Li Wang
What company does Yu-Li Wang work for?
Yu-Li Wang works for Carnegie Mellon University
What is Yu-Li Wang's role at the current company?
Yu-Li Wang's current role is R. Mehrabian Professor of Biomedical Engineering.
What is Yu-Li Wang's email address?
Yu-Li Wang's email address is yu****@****med.edu
What is Yu-Li Wang's direct phone number?
Yu-Li Wang's direct phone number is (412) 268*****
What schools did Yu-Li Wang attend?
Yu-Li Wang attended Harvard University, National Taiwan University.
What skills is Yu-Li Wang known for?
Yu-Li Wang has skills like Biomedical Engineering, Cell Biology, Biomechanics, Optical Imaging, Computational Biology, Biomaterials, Cell Migration.
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