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Trained microbiologist and synthetic biologist with a background in organic chemistry. I work at the interface of microbiome research, synthetic biology, and next-generation sequencing. I want to develop the next generation of whole cell therapeutics to treat chronic microbial diseases.Summary- Co-founder and CEO of skin microbiome company, Phi Therapeutics- Developed relationships with microbiome and dermatology KOLs in academia and industry- Deep understanding of the safety and regulatory landscape in dermatology for both cosmetic and therapeutic products- Successfully applied for patents (3), an academic fellowship (1) and an industry grant (1)- Unique mix of critical, analytical and multidisciplinary thinking that drives insight- Skilled in communicating scientific concepts in oral and written formats- Thrive in a dynamic, challenging, and diverse environment- Experience in multi-group collaborations, project management, managing a team of scientists - 7 years of combined post-doctoral and industry experience as microbiome and synthetic biologist- Productive independent microbiologist: extensive training in next-gen sequencing (NGS) and managing large datasets, synthetic biology, and metabolic engineering.Laboratory ExperienceSynthetic Biology: Large-scale gene cluster assembly from multiple fragments, RBS and promoter optimizationCell and Molecular Biology: cell culture (endothelial and epithelial cells), enzyme kinetics, skin punch biopsies, flow cytometry, cytokine bead analysis, and cloningSequencing: Next-gen sequencing (NGS), bacterial whole genome sequencing, 16S profiling, RNASeqBiochemistry: Western blots, protein purification, mass spectrometry (GC-MS, LC-MS), bioconjugation.
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Founder And CtoPhylaSan Francisco, Ca, Us -
Founder & CtoPhyla Apr 2023 - PresentSan Francisco, California, Us -
Founder And CeoPhyla Feb 2016 - May 2023San Francisco, California, UsPrecise microbiome editing for the treatment of chronic diseases.- Successfully negotiated a co-development deal with leading skincare company to enter human trials and launch first-in-class acne product- Interviewed over 200 stakeholders (patients, doctors, KOLs, academia, industry professionals) to validate business idea- Wrote successfully-funded NIH SBIR grant to enable R&D, as well as IRBs, regulatory communications, and patents - Collected and analysed skin microbiome samples, including isolation and characterization of bacterial strains and bacteriophages- Carried out genotypic and phenotypic assessment of bacterial strains, including assay development for immunogenic markers using sequencing (NGS), in vitro cell based assays, cytokine bead array analysis, punch biopsy experiments, and mouse and pig models- Attended and presented at several biotech conferences, including BIO, BIO Investor Forum, and several microbiome-focused conferences -
Chief Executive OfficerPhyla Feb 2014 - May 2023San Francisco, California, Us -
Postdoctoral ScholarUcsf Mar 2011 - Jan 2016San Francisco, California, UsAdvisor: Michael FischbachHuman Microbiome research. Investigating the interaction between gut bacteria and the immune system.- Gut microbial influence on host immunity: I identified several secondary bile acid metabolites produced by keystone members of the genus Clostridium that are potent stimulators of the immune system. In a mouse model, two lead compounds modulated TH17 and Treg cell function via novel nuclear receptor pathways.- Elucidation of the bile acid 7-dehydroxylation pathway: Bile acid dehydroxylation is one of the most significant metabolic transformations by gut microbiota, and it affects our metabolism, immunity, and health. In order to fully characterize this pathway, I performed whole genome sequencing of active strains and profiled active gene clusters using RNASeq. Using synthetic biology, I transferred these clusters into other expression systems and validated the metabolic intermediates using GCMS and LCMS. Further, I characterized the pivotal and rate-limiting enzymes in this pathway via heterologous expression, purification, and analysis. -
Graduate StudentJohns Hopkins University Aug 2000 - Feb 2011Baltimore, Md, UsAdvisor: Dr. Tamara HendricksonPh.D. in bioorganic chemistry. Structural and Biochemical Characterization of GPI Transamidase in Yeast.- Conducted a structural and biochemical characterization of the membrane-bound enzyme complex GPI transamidase, with an emphasis on the Gaa1 subunit. - By heterologous expression of the soluble truncated forms of these membrane-bound subunits, I demonstrated that the core of this enzyme assembles as a dimer-of-dimers, analogous to the functional configuration of some caspases.
Yug Varma Skills
Yug Varma Education Details
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The Johns Hopkins UniversityBioorganic Chemistry -
Indian Institute Of Technology, BombayChemistry
Frequently Asked Questions about Yug Varma
What company does Yug Varma work for?
Yug Varma works for Phyla
What is Yug Varma's role at the current company?
Yug Varma's current role is Founder and CTO.
What is Yug Varma's email address?
Yug Varma's email address is yu****@****ics.com
What is Yug Varma's direct phone number?
Yug Varma's direct phone number is +144382*****
What schools did Yug Varma attend?
Yug Varma attended The Johns Hopkins University, Indian Institute Of Technology, Bombay.
What are some of Yug Varma's interests?
Yug Varma has interest in Johns Hopkins, Wayne State University.
What skills is Yug Varma known for?
Yug Varma has skills like Protein Chemistry, Molecular Biology, Protein Purification, Biochemistry, Cell Culture, Chemistry, Hplc, Mass Spectrometry, Western Blotting, Pcr, Nmr, Science.
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