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1. Over 25 years of experience in solving sophisticated biomedical problems and integration of complex cross-disciplinary projects.1. Expertise in molecular immunology, transcriptional regulation, high throughput (microarray) data analysis, and protein biochemistry.3. Analysis of protein signaling cascades using proteomic methods such as: yeast two hybrid system, immunoprecipitation, tandem affinity purification, microsequencing by multidimensional mass-spectroscopy.4. Analysis of candidate genes in knock-out and transgenic models.5. Advanced analytical and visualization methods such as confocal microscopy, DNA and RNA - FISH, isolation of rare cell types by fluorescent cell sorting. 6. Multidimensional flow cytometry (including mass-spectrometry coupled flow cytometry by CyTOF) of intracellular proteins (phospho-flow) and RNA.7. Using recombinant DNA methods for production of transgenic animals.8. Protein biochemistry: HPLC, FPLC, Western-blot.9. Chromatin biochemistry: chromatin immunopreciptation coupled to whole genome microarray analysis and deep sequencing (Chip-Chip, Chip-Seq)10. Programming in PERL and R; statistic analysis of microarray data.11. Technical project management: preparing grant proposals, budget planning, resource sharing, teaching stuff members. 12. 13 publications in peer-reviewed journals, including Annu Rev Immunol., Cell, Development etc.; three invited talks at international conferences.
Cellformatica
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- cellformatica.com
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- 2
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Co-Founder And CeoCellformaticaCalifornia, United States -
Co-Founder And Interim CeoCellformatica Jan 2023 - Present -
Co-Founder And Interim CsoParhelia Biosciences Jan 2021 - Present -
Co-FounderAkoya Biosciences, Inc. Jan 2016 - Present -
Senior Research ScientistStanford University School Of Medicine Jul 2009 - Present -
PostdocUc Berkeley Jul 2003 - Jun 2009Using microarray analysis of tissues microdissected from malaria mosquito embryos discovered molecular pathway for regulation of drought tolerance in malaria mosquitoes. (ref. 1) and (in press). Using RNA-FISH discovered and analyzed variabilities in transcriptional patterning networks in insects (ref. 2). Was one of the first in the world to use whole genome tiling microarrays for analysis of non-coding and reverse transcription in Drosophila genome. Using chromatin immunoprecipitation isolated RNA involved in regulation fo chromatin function. In collaboration with Affymetrix, Inc. took part in designed whole genome tiling microarray for Anopheles gambiae – malaria mosquito.Performed multiple studies on identification and analysis of transcription factor binding sites in enhancers of Drosophila patterning genes -
Graduate Research FellowWeizmann Institute Of Science Jun 1995 - Jun 2003Worked as part of a team of scientists that used yeast two hybrid screening coupled to human cDNA library screening to discover caspase-8 – central effector of programmed cell death pathways induced by variety of immune receptors (ref. 6) and Patent 1. Using yeast two hybrid screening coupled to in silico analysis of public DNA databases discovered cFLIP/CASH a caspase-like inhibitor of cell death, central oncogene involved in colorectal cancer and other malignant conditions (ref.5) and Patent 2. Analysed both genes using tissue culture and transgenic models.Using immunoprecipitations coupled to 2D-gel electrophoresis and nano-electrospray mass-spectroscopy analyzed the components of signaling complexes bound to cFLIP in cancer cell lines.Developed an innovative approach for isolation of genes involved in regulation of programmed cell death.
Yury Goltsev Skills
Yury Goltsev Education Details
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Molecular Immunology -
520
Frequently Asked Questions about Yury Goltsev
What company does Yury Goltsev work for?
Yury Goltsev works for Cellformatica
What is Yury Goltsev's role at the current company?
Yury Goltsev's current role is Co-Founder and CEO.
What is Yury Goltsev's email address?
Yury Goltsev's email address is go****@****ord.edu
What schools did Yury Goltsev attend?
Yury Goltsev attended Weizmann Institute Of Science, Moscow Institute Of Physics And Technology (State University) (Mipt), 520.
What skills is Yury Goltsev known for?
Yury Goltsev has skills like Cell, Tissue Culture, Biochemistry, Molecular Biology, Dna, Western Blotting, Bioinformatics.
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Yury Goltsev
Menlo Park, Ca -
Yury Goltsev
Stanford, Ca
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