Zachary Jacobs Email & Phone Number

Boston, Ma, Us

• Evaluate and rate AI model outputs according to detailed project-specific rubrics, ensuring alignment with quality and accuracy standards.• Debug and refine code generated by models, troubleshooting errors and enhancing outputs to meet project requirements and functional goals.

Boston, Massachusetts, United States

• Graduate Teaching Assistant for CS5008 Data Structures, Algorithms, and their Applications within Computer Systems under Prof. Amit Shesh.• Partnered with the course professor and other TAs to teach 150+ students.• Provided 1-on-1 support to students on course material and assignments through scheduled office hours and tutoring.• Lead a weekly lab session for 30+ students to encourage discussion and further explore course concepts.• Graded, troubleshot, and provided detailed feedback on student coding assignments.

• Property Manager• Live Musician

Worcester, Ma

• Performed routine and non-routine testing within a GMP environment. Testing performed on raw material, in-process product, final bulk product, stability and environmental monitoring samples.• Laboratory assays: Bioburden, TOC, Conductivity, Contamination Check, Gram Stain. Analyzes test data and evaluates results. Monitored data trends to support assay performance.• Used LIMS for sample management and assay documentation. • Coordinated processing and shipping of samples to outside laboratories for testing.• Assisted the writing of reports for the validation of developing test methods.• Provided training to analysts on various laboratory assays and procedures.• Performed preventative maintenance on laboratory equipment and assets.• Provided audit support to management during internal and external agency inspections.

Worcester, Ma

Developing cell based assays to identify lead molecules for anti-inflammatory diseases.• Characterized the glucocorticoid response element reporter assay used for combinational screening. Screened 53 small molecules in combination with glucocorticoids to generate data for “GO/NO GO” decisions within the project team.• Investigated the mechanism of action of our lead molecule in combination with glucocorticoids through mRNA analysis of glucocorticoid specific transcripts (GLIZ, PER1 and FKBP5) and protein analysis of glucocorticoid receptor (t-GR/ pGR (Ser211)).• Profiled lead antibody candidates for their ability to internalize and co-localize to lysosome compartments by infecting cells with Baculovirus using BacMam technology to label the compartment organelles. Receptor mediated internalization was confirmed using Amnis Imagestream. • Generated stable cell lines used for identification of internalizing antibodies using lipid based transfections.

Worcester, Ma

• Responsible for sanitizing, preparing and distributing rodent cage set-ups for support of research.• Responsible for disinfecting animal rooms and properly processing waste disposal.• In charge of receiving and distributing laboratory materials and supplies, as well as animal shipments throughout the facility.• Accountable for maintaining records, including equipment operation, animal identification, health checks and room conditions. • Performed rodent, rabbit, pig, and canine husbandry.

Worcester, Ma

• Responsible to sanitize, prepare and distribute rodent cage set-ups for support of research, using sterile technique in barrier rooms or clean housing systems.• Operator of sanitation equipment (autoclave, cage washer). • Responsible to disinfect animal rooms and properly process waste disposal.• Accountable to maintain records, including equipment operation, animal identification, health checks and room conditions. • Performed rodent husbandry, as needed.

Master Of Science - Ms, Computer Science, 4.0 / 4.0

Bachelor Of Science - Bs, Molecular And Cell Biology, Statistics Minor, 3.614 / 4.0 Cum Laude