Directing both of the analytical development (AD) and clinical stage quality control (ASQC) teams of Suzhou Abogen Bioscience to support its mRNA therapeutic platform. Abogen is a clinical-stage biotechnology company advancing mRNA-based therapeutics for the treatment of cancer and infectious diseases. Since its establishment in January 2019, Abogen has developed its own mRNA technology platform and proprietary delivery system which empowers the development of a series of vaccine and drug product candidates.

Analytical Sciences at WuXi Biologics, facilitates new drug R&D endeavors in collaboration with discovery and CMC development laboratories， offering comprehensive, analytical services for protein therapeutics development, including developability studies in-process CMC support, product characterization, lot release, stability studies and IND/BLA dossier preparation.Jul 2020 - Apr 2021CMAB (now WuXi Biologics)

Established and directed protein science and analytical team to support novel monoclonal antibody discovery through advanced single-cell sorting platform.

Therapeutic Protein expression and purification, fermentation, peptide synthesis; biochemical and biophysical characterization, QC of API, formulation; Analytical Method Development & Transfer; Edited and reviewed SOPs for GMP manufacturing facility; Team Management.Led a team of 3-7 scientists in R&D Laboratory for peptide/protein therapeutics development, including SPPS peptide synthesis, recombinant protein expression, fermentation, purification and formulation, characterization and analysis. Analytical method development for both API and formulations. More than 10 generic pharmaceuticals and formulations were developed, and some of these drugs has already transferred for manufacturing.

Sr QC analyst, GMP testing of Provenge（first cancer vaccine） treated human immune cells, A cell-based cancer immunotherapy for prostate cancer, including flow-cytometry, ELISA, CBC, gram staining and viable count. Training QC associates. familiar with LIMS system and GMP regulations.

Protein & Antibody Purification; Antibody Characterization, Conjugation and Quality Control; Downstream Process Development; Protein Nanoparticles Purification for Drug Delivery.Directed a team of scientists in the production of antigens, antibodies and antibody conjugates to support preclinical tests. Experienced on cell culture, including flasks, bioreactors, automated bioreactors, antibody purification, characterization and conjugation. Antibody affinity screening utilizing surface plasma resonance (SPR), ELISA, epitope mapping, sequencing, peptide-mapping and LC-MS.

Molecular Biology, Protein Expression & Purification; Biophysical & Biochemical Characterization; RNA Research; Various Enzymatic Assay; Protein Modeling & Drug Discovery; Molecular Biology and Protein Chemistry Laboratory Set Up. Experienced with MALDI-TOF mass spectroscopy, AFM and Biacore (SPR) to characterize protein complex, experienced with plasmid construction, protein expression and purification using both yeast and bacterial system. familiar with protein crystallization and various enzymatic assays.

Protein chemistry research, including protein expression and purification, biochemical and biophysical characterization. experienced in protein unfolding and folding, stability, SPR, UV, fluorescence, NMR analysis. ligand-receptor binding interaction in protein complex.