Zhao Chen Email and Phone Number
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A highly motivated scientist with a strong background in molecular and cell biology. Proven track record of publications and extensive experience in next-generation sequencing, gene editing, and Immunotherapy. Highly organized and detail-oriented with a strong ability to identify and solve complex scientific problems. Collaborative team player with excellent communication skills. Passionate about translating scientific discoveries into innovative therapies.
Sorrento Therapeutics, Inc.
View- Website:
- sorrentotherapeutics.com
- Employees:
- 114
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Senior ScientistSorrento Therapeutics, Inc.San Diego, Ca, Us
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Chief ScientistRedybio May 2024 - PresentRedyBio is a contract research organization (CRO) established by a team of seasoned scientists, quality professionals, and biotechnology service experts. With unparalleled experience and scientific expertise, our team offers cutting-edge technologies and innovative solutions in genomic science, reagent development and production, and advanced bioassay development, driving advancements in drug discovery and development.● Established and managing research laboratory● Stable cell line construction● CRISPR gene editing and off-target discovery● Retro/Lentivirus production ● iPSC reprograming and differentiations● In vitro and in vivo Immunoassays ● Bioassay development● Superdonor PBMC -
Senior ScientistSorrento Therapeutics, Inc. Jul 2021 - Sep 2023San Diego, California, Us● Lead discovery of novel CAR-T platform harboring advantages of CAR-T and TCR-T. Design andconduct preclinical studies for IND enabling. Patent filed and study published in a scientific journal.● CRISPR/Cas9 genome editing in iPSC and differentiation to T/NK lineage. Screened gene-editing locifor stable transgene expression in iPSC-CAR-T/NK. Optimized iPSC-CAR-NK expansion protocol.● Designed and researched gene-editing CAR-T to improve gene-editing efficiency at various loci.● Implemented overexpression and knockdown in the same construct to improve CAR-T efficacy underrepressive TME.● Established and optimized gene-editing in non-activated T cells to preserve T cell stemness, resulting inbetter CAR-T cell expansion in the xenograft model.● Worked with mRNA and formulation team to develop LNP-mRNA for in-vivo CAR-T therapy.
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Assistant Project ScientistUniversity Of California, San Diego Aug 2015 - Jul 2021La Jolla, Ca, Us• Combine In situ Sequencing and Expansion microscopy to study genome 3D structure• High throughput screening by CRISPR deletions of highly interacted genomic loci to discover essential non-coding regions for maintaining chromatin organization and cell viability• Constructing RNA-seq libraries from OA and RA patient samples for dry lab analysis• Designed and performed high-throughput strategy to generate ChIP-seq and Bisulfite sequencing data for dry lab to study the DNA motifs accounting for histone modifications and DMRs • Discovered and tested novel transcription factor cocktails in collaborating with dry lab to transdifferenciate human primary fibroblast into various cell types (NPCs, HSCs, hepatocytes and cardiomyocytes) -
Postdoctoral ResearcherUniversity Of California, San Diego Nov 2009 - Jul 2015La Jolla, Ca, Us• Validate activity of predicted enhancer elements in human fibroblasts using luciferase reporter assay.• Study directed differentiation of hESCs by novel transcription factor cocktails into neural progenitor cells and mesenchymal stem cells.• Manipulate DNA motif sequences in terms of modulating histone modification by knock-in mutated motif sequences in hESCs via TALEN and/or CRISPR/Cas9 genome editing tool, followed by ChIP-qPCR to compare changes in histone marks. • Validate predicted chromosome interactions by 3C-qPCR and DNA-FISH.• Monitor progress of lineage differentiation by knock-in fluorescent protein tag to lineage specific marker gene in hESCs.
Zhao Chen Skills
Zhao Chen Education Details
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Wuhan UniversityBiophysics -
Wuhan UniversityBiotechnology
Frequently Asked Questions about Zhao Chen
What company does Zhao Chen work for?
Zhao Chen works for Sorrento Therapeutics, Inc.
What is Zhao Chen's role at the current company?
Zhao Chen's current role is Senior Scientist.
What is Zhao Chen's email address?
Zhao Chen's email address is zc****@****csd.edu
What schools did Zhao Chen attend?
Zhao Chen attended Wuhan University, Wuhan University.
What skills is Zhao Chen known for?
Zhao Chen has skills like Cell Biology, Western Blotting, Protein Expression, Immunohistochemistry, Cell Culture, Molecular Cloning, Differentiation, Molecular Biology, Pcr, Cell, Genomics, Biophysics.
Who are Zhao Chen's colleagues?
Zhao Chen's colleagues are Claudia Baez Ruiz, Megan Truong, Hongbo Si, Brett Bennion, Andrew Wong, Jesus Hernandez, Jack Lee.
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