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• In vitro pharmacologist with 10+ years of pharmaceutical industry experience in small-molecule and immunotherapeutic drug discovery.• Expertise in development and deployment of multiple orthogonal assays for inhibitor discovery, enzymology, mechanism of action studies, and a variety of cellular target-engagement, functional, phenotypical assays across diverse protein target classes.• Excellent team member to work collaboratively with cross-functional groups, which efforts enabled the discovery of multiple clinical candidates such as IPN60090 (phase 1 trials).• Authored Biochemistry report to FDA.• Solid supervisory experience managing interns, Research Associates and Scientists.
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Principle ScientistXilio Therapeutics, Inc.Boston, Ma, Us -
Principal ScientistXilio Therapeutics, Inc. Jul 2022 - Apr 2024Waltham, Massachusetts, Us• Act as the head of biochemistry group, analyzing protease activity in different biological samples and providing input into translational studies and pharmacology modeling.• Serve as subject matter expert on protease biochemistry, and write reports to FDA.• Build team and mentor junior scientists -
Senior ScientistXilio Therapeutics, Inc. Mar 2022 - Jul 2022Waltham, Massachusetts, Us• Devise, perform and supervise biochemical experiments to characterize the activation of therapeutic cytokines.• Integrate technologies that improve the throughput of multiple assay formats by working with in-house collaborators and external vendors.
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Institute Research ScientistMd Anderson Cancer Center Oct 2017 - Mar 2022Houston, Tx, Us• Act as in vitro pharmacology lead to validate early-stage targets, evaluate hit identification strategies, and manage HTS screening assays in hit-to-lead space.• Leverage biochemical and cellular technologies to support SAR study and the refinement of key molecular pharmacology readouts.• Work closely with cross-functional groups (medicinal chemistry, ADME/PK, biology) to build preclinical data packages for clinical candidate nomination and complete documentation for regulatory filing.• Provide biophysics and enzymology expertise to the mechanism-of-action studies across diverse protein target classes (e.g. kinase, RNase, ligase, histone modifier, PPI, etc.). -
Institute Research InvestigatorMd Anderson Cancer Center Mar 2014 - Sep 2017Houston, Tx, Us• Evaluate programs coming from collaborators/literature, and make science driven Go/No Go decisions in order to advance trackable programs to the hit-to-lead space.• Perform internal HTS, fragment-screening and coordinate with CRO to conduct external HTS campaign.• Develop, implement, and execute drug screening assays for drug targets involved in various pathogenic mechanism (e.g. metabolism, epigenetics, immuno-modulation, etc.).• Act as institute super user of multiple cutting-edge technologies, write SOP, and provide training.• Implement residence-time assay that contributed to the discovery of slowly reversible GLS inhibitor IPN60090, currently in Phase I clinical trial.
Zhen Liu Skills
Zhen Liu Education Details
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Texas A&M UniversityChemistry -
University Of South DakotaChemistry
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Nankai UniversityChemistry
Frequently Asked Questions about Zhen Liu
What company does Zhen Liu work for?
Zhen Liu works for Xilio Therapeutics, Inc.
What is Zhen Liu's role at the current company?
Zhen Liu's current role is Principle Scientist.
What is Zhen Liu's email address?
Zhen Liu's email address is zl****@****ing.org
What schools did Zhen Liu attend?
Zhen Liu attended Texas A&m University, University Of South Dakota, Nankai University.
What skills is Zhen Liu known for?
Zhen Liu has skills like Assay Development, Protein Purification, Cell Based Assays, Elisa, Fret, Spr, X Ray Crystallography, Enzyme Kinetics, Alphascreen, Fragment Based Screen, Western Blotting, Mass Spectrometry.
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