Acelot is treating functional protein misfolding diseases where the appropriate therapeutic mechanism is a restoration of the normal protein homeostasis. Functional misfolded proteins are found in various diseases such as ALS, FTD, Parkinson’s, diabetes and cancer. Acelot’s platform combines generative AI, molecular dynamics simulations and proprietary assays to discover small molecules that restore the homeostasis of misfolded proteins in various diseases. We have a pipeline of hit-to-lead discovery compounds across multiple indications, along with an IND-ready candidate for ALS. Our platform was invented by UCSB Computer Science Professor Dr. Ambuj Singh.
Acelot’s first development candidate, ACE-2223, is a first-in-class orally bioavailable small molecule that will undergo IND-enabling studies in 2024. ACE-2223 disrupts the misfolded forms of TDP43 and restores functional TDP43. It acts upon the misfolded conformations of TDP43 found across various patient populations, including ALS, FTD and Alzheimer’s. ACE-2223 has excellent brain penetrance and ADME properties. Acelot also has a robust discovery pipeline.
Company Details
- Employees
- 18
- Address
- 329 Oyster Point Blvd, South San Francisco,california 94080,united States
- Phone
- +1 805 683 4002
- in****@****lot.com
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- acelot.com
- Keywords
- Alzheimer's disease, drug discovery and development, neurodegenerative diseases, small molecules, machine learning, data science.
- HQ
- South San Francisco, California
Acelot Questions
Acelot's helpline number is +1 805 683 4002
Acelot's website is acelot.com
Acelot's LinkedIn profile is https://www.linkedin.com/company/acelot-inc.
Acelot has
18 employees.
View email and phone details for 18
employees at Acelot.
Acelot's industry is
Biotechnology Research
Acelot's top competitors are
Kezar Life Sciences,
Abiosciences,
Allogene Therapeutics,
Bmc,
Acera Therapeutics,
Alector,
Acelot Innovation Private Limited,
Denali Therapeutics,
Annexon Biosciences,
Apeximmune Therapeutics.
Acelot's support email address is info@acelot.com
Acelot's categories are Biotechnology Research
