Akari Therapeutics, Plc

Akari Therapeutics, Plc company information, Employees & Contact Information

Akari Therapeutics is a biotechnology company developing next-generation precision bi-functional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its innovative ADC discovery platform, the Company has the ability to generate novel bi-functional ADC candidates and optimize them based on the desired application to target a range of cancers to fuel a growing pipeline. Akari’s lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells and with a proprietary linker delivers its novel PH1 payload directly into the tumor. Unlike current ADCs that use tubulin inhibitors and DNA damaging agents as their toxin classes, PH1 is a novel bi-functional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Given this mechanism, AKTX-101 has the potential to overcome many of the shortcomings of current ADCs, off-target toxicity and resistance. In preclinical studies, AKTX-101 has shown to have superior activity, prolonged survival, less resistance and better tolerability and safety. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival in preclinical models. The Company is generating validating data on its novel payloads to advance its pipeline.

Company Details

Employees
13
Address
75-76 Wimpole Street, London,w1g 9rt,united Kingdom
Industry
Biotechnology Research
NAICS
Research and Development in Biotechnology (except Nanobiotechnology)
HQ
London
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News

Akari Therapeutics Announces Launch of CEO Corner Platform - The Manila Times

Akari Therapeutics Announces Launch of CEO Corner Platform The Manila Times

Akari Therapeutics Releases “Meet the Team” Video Featuring Recently Appointed Mark F. Kubik, Head of Business Development – Oncology - Sahm

Akari Therapeutics Releases “Meet the Team” Video Featuring Recently Appointed Mark F. Kubik, Head of Business Development – Oncology Sahm

Akari Therapeutics to Participate in the Virtual Investor Closing Bell Series - Yahoo Finance

Akari Therapeutics to Participate in the Virtual Investor Closing Bell Series Yahoo Finance

Akari Therapeutics Appoints Abizer Gaslightwala as CEO - citybiz

Akari Therapeutics Appoints Abizer Gaslightwala as CEO citybiz

Akari Therapeutics Files Provisional Patent Application for Novel Antibody Drug Conjugate Platform Targeting Cancer Through Spliceosome Modulation | AKTX Stock News - Quiver Quantitative

Akari Therapeutics Files Provisional Patent Application for Novel Antibody Drug Conjugate Platform Targeting Cancer Through Spliceosome Modulation | AKTX Stock News Quiver Quantitative

Next-Gen Cancer Drug Developer Akari Therapeutics Showcases Novel IO-Payload ADC Platform - Stock Titan

Next-Gen Cancer Drug Developer Akari Therapeutics Showcases Novel IO-Payload ADC Platform Stock Titan

Akari Therapeutics Files Two New Patents for Immuno-Oncology Mode of Action for Novel ADC Platform Utilizing Spliceosome Modulating Payload PH1 - Yahoo Finance

Akari Therapeutics Files Two New Patents for Immuno-Oncology Mode of Action for Novel ADC Platform Utilizing Spliceosome Modulating Payload PH1 Yahoo Finance

Akari Therapeutics Appoints Abizer Gaslightwala to Board - citybiz

Akari Therapeutics Appoints Abizer Gaslightwala to Board citybiz

Nomacopan Receives Orphan Drug Designation for Bullous Pemphigoid - Medical Professionals Reference

Nomacopan Receives Orphan Drug Designation for Bullous Pemphigoid Medical Professionals Reference

Akari Therapeutics Announces $2.5 Million Registered Direct Offering - The Manila Times

Akari Therapeutics Announces $2.5 Million Registered Direct Offering The Manila Times

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