Chrom Rare

Chrom_Rare is a EU-funded consortium relying on a collaborative effort of multi-disciplinary research teams all around Europe, that share the aim of working towards unveiling the molecular basis of chromatinopthies to delineate innovative therapeutic solutions. The goal Chromatinopathies (CPs) are a group of rare genetic diseases, which share clinical features as well as causal genetic alterations, leading to the inactivation of chromatin regulators involved in gene expression control and 3D chromatin organization.Within the framework of Chrom_Rare, our main goal is to set-up an intra-sectoral, cross-disciplinary training programme that would prepare the next generation of researchers equipped with advanced theoretical, technical and computational skills to study fundamental aspects of chromatin biology and their impact on chromatinopaties (CPs). In parallel, Chrom_Rare will devise new strategies to translate the molecular findings into new diagnostic and therapeutic approaches for patients affected by CPs. We are thus looking for Doctoral Candidates that will join this PhD programme and that will work towards understanding the molecular basis of chromatinopathies, specifically aiming at: 1) developing multiple disease models recapitulating the main clinical features of CPs (WP1). 2) investigating the genetic, epigenetic and topological determinants of CPs (WP2). 3) uncovering perturbed regulatory circuitries suitable for therapeutic intervention (WP3). The projects The consortium provides 10 PhD projects (DCs), distributed among the different partner laboratories. Follow this link to get access to all information regarding the Chrom_Rare projects and instructions on how to apply. https://chromrare.eu/index.php/application/ Apply by March 31st! This project has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101073334.