Covalent company information, Employees & Contact Information

Mass spectrometry methods and mathematical PK/PD model for decision tree-guided covalent drug development Nature

Advancing Covalent Ligand and Drug Discovery beyond Cysteine ACS Publications

Novartis bets on covalent chemistry in $1B Matchpoint deal FirstWord Pharma

Highly Precise Prediction of Micro‐ and Supra‐pKa Based on 3D Descriptors Integrating Non‐Covalent Interactions Wiley Online Library

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers ACS Publications

Research progress on covalent inhibitors targeting alkaline amino acids ScienceDirect.com

Designing Lithium-Decorated Aza-Triphenylene-Based Covalent Organic Frameworks for High-Capacity Hydrogen Storage: A Computational Study ACS Publications

Development of covalent inhibitors: Principle, design, and application in cancer - Zheng - 2023 - MedComm – Oncology Wiley Online Library

The expanding repertoire of covalent warheads for drug discovery ScienceDirect.com

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 Nature

Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans ACS Publications

A novel, covalent broad-spectrum inhibitor targeting human coronavirus M Nature

Probing the Protein Kinases′ Cysteinome by Covalent Fragments Wiley Online Library

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry Nature

The Ascension of Targeted Covalent Inhibitors ACS Publications

Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis ACS Publications

Biospecific Chemistry for Covalent Linking of Biomacromolecules ACS Publications

Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRasG12C ACS Publications

Discrete Dynamics of Warhead Modulation on Covalent Inhibition of Oxyr: A QM/MM Study ACS Publications

Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein–Protein Interaction Inhibitors ACS Publications

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease Nature

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase ACS Publications

New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design ACS Publications

Discovery of novel non-peptidic and non-covalent small-molecule 3CL Nature

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72 ACS Publications

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity Nature

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor ScienceDirect.com

Metal- and covalent-organic framework mixed matrix membranes for CO ScienceDirect.com

Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor ScienceDirect.com

A non-covalent antibody complex for the delivery of anti-cancer drugs ScienceDirect.com

Discovery of macrocyclic covalent inhibitors for severe acute respiratory syndrome coronavirus 2 3CL protease ScienceDirect.com

Covalent inhibitors of GAPDH: From unspecific warheads to selective compounds ScienceDirect.com

Reconfigurable liquids enabled by dynamic covalent chemistry - Li - 2024 - Aggregate Wiley Online Library

Molecular determinants of acrylamide neurotoxicity through covalent docking Frontiers

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors ACS Publications

Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases ACS Publications

Intrinsic self-healing thermoset through covalent and hydrogen bonding interactions ScienceDirect.com

An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors Nature

Covalent Organic Frameworks as a Decorating Platform for Utilization and Affinity Enhancement of Chelating Sites for Radionuclide Sequestration Wiley Online Library

Design of moldable hydrogels for biomedical applications using dynamic covalent boronic esters ScienceDirect.com

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal Wiley Online Library

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase ACS Publications

Current Trends in Metal–Organic and Covalent Organic Framework Membrane Materials Wiley Online Library

Succinimidyl Ester Surface Chemistry: Implications of the Competition between Aminolysis and Hydrolysis on Covalent Protein Immobilization ACS Publications